| 产品详情 |
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| Antigenic Specificity | IL-6 |
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| Clone | polyclonal |
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| Host Species | Goat |
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| Reactive Species | rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | ELISA Capture |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-rat IL-6. Interleukin 6 (IL-6) is a prototypic member of the IL-6 superfamily of cytokines. IL-6 is secreted by a variety of lymphoid and non-lymphoid cells including T cells, B cells, monocytes, fibroblasts, hepatocytes, endothelial cells, keratinocytes, etc. Mature Rat IL-6 is a 187 aa residue protein. At the protein sequence level, there is approximately 39% identity between rat and human IL-6, and 87% identity between mouse and rat IL-6. The production of IL-6 can be induced by numerous signals such as mitogenic or antigenic stimulation, lipopolysaccharides, calcium ionophores, cytokines, and viruses.IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6 R) and a subunit (gp130) that acts as the universal signal-transducing element for all IL-6 family cytokines. IL-6 activity is essential for the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. One of the most important mechanism is that IL-6 is a key factor that reciprocally regulates Th17 and Foxp3+ Treg differentiation by inhibition of TGF-β induced Foxp3 and induction of RORγt, a Th17 lineage-specific transcription factor.Elevated serum IL-6 levels have been observed in a number of pathological conditions, including bacterial and viral infections, trauma, autoimmune diseases, inflammations and malignancies. |
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| Immunogen | n/a |
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| Other Names | Interleukin-6, B cell stimulating factor-2 (BSF-2), Cytotoxic T cell differentiation factor (CDF), Hepatocyte stimulating factor (HSF), Hybridoma/plasmacytoma growth factor (HPGF) |
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| Gene, Accession # | Gene ID: 24498 |
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| Catalog # | 517701 |
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| Price | |
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| Order / More Info | IL-6 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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