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| Product Name | 3-Deazaneplanocin A hydrochloride |
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| Description | Histone methyltransferase inhibitor; decreases global histone methylation. Inhibits EZH2 histone methyltransferase and s-adenosylhomocysteine (SAH) hydrolase activity. Blocks trimethylation of lysine 27 on histone H3 and lysine 20 on histone H4 in vitro. Induces apoptosis in multiple cancer cell lines and has no apoptotic effect on normal cells. Enhances Oct4 expression in chemically induced pluripotent stem cells (CiPSCs). Purity 98%. MW (observed): 298.73 |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol hydrochloride. DZNep, NSC 617989 |
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| Gene, Accession, CAS # | CAS: 120964-45-6 |
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| Catalog # | 4703/1 |
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| Order / More Info | 3-Deazaneplanocin A hydrochloride from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 17437993, 29096702 |
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| 产品资料 |
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