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| Product Name | MP A08 |
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| Description | Selective ATP competitive sphingosine kinase 2 and 1 (SphK2/1) inhibitor (Ki values are 6.9 and 27 μM, respectively). Exhibits selectivity for SphK 1 and 2 over other kinases. Inhibits cellular S1P production and increases sphingosine and ceramide levels in vitro. Also induces mitochondrial-associated apoptosis. Reduces tumor growth in a human lung adenocarcinoma xenograft mouse model, by inducing apoptosis and suppressing angiogenesis. Cell permeable. MW (observed): 519.64. |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide. NSC 122314 |
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| Gene, Accession, CAS # | CAS: 219832-49-2 |
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| Catalog # | 5803/10 |
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| Price | |
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| Order / More Info | MP A08 from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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| 产品资料 |
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