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| Product Name | Temsirolimus |
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| Description | mTOR inhibitor; inhibits tumor growth in breast cancer cell lines (IC50 values are 1.6 and 4.3 nM for SKBr3 and BT474, respectively). Inhibits HIF-1α-mediated VEGF production in breast cancer cell lines (BT474 and MDA-MB-231). Directly inhibits serum and VEGF mediated endothelial cell proliferation and morphogenesis in vitro and vessel formation in vivo. Causes G1/S cell cycle arrest in multiple cancer cell lines. Antiangiogenic. Activates autophagy. Purity 98%. MW (observed): 1030.29 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Rapamycin 42-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate]. CCI-779 |
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| Gene, Accession, CAS # | CAS: 162635-04-3 |
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| Catalog # | 5264/10 |
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| Order / More Info | Temsirolimus from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 29930108 |
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