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| Product Name | BMS 536924 |
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| Description | Dual inhibitor of the insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) (IC50 values are 73 and 100 nM respectively). Inhibits receptor autophosphorylation and downstream MEK1/2 and Akt signaling. Induces G1 arrest and apoptosis in ML-1 cells; also inhibits cell proliferation in multiple tumor types. Reverses EMT through the attenuation of Snail mRNA expression in MCF10A cell over expressing IGF1R. Purity 98%. MW (observed): 479.96 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-3-[7-methyl-5-(4-morpholinyl)-1H-benzimidazol-2-yl]-2(1H)-pyridinone |
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| Gene, Accession, CAS # | CAS: 468740-43-4 |
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| Catalog # | 4774/10 |
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| Price | |
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| Order / More Info | BMS 536924 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 25643582, 28598329 |
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| 产品资料 |
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