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| Product Name | AT 101 |
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| Description | R-(-)-enantiomer of gossypol (Cat. No. 1964). Mimics the BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis in vitro through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. Delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo. Purity 98%. MW (observed): 518.56 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (-)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde |
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| Gene, Accession, CAS # | CAS: 90141-22-3 |
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| Catalog # | 3367/10 |
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| Price | |
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| Order / More Info | AT 101 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 27203692 |
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| 产品资料 |
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