| 产品详情 |
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| Product Name | FRAX 486 |
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| Description | Potent p21-activated kinase (PAK) inhibitor (IC50 values are 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively). Blocks and reverses the DISC1 knockdown-induced reduction in dendritic spine size in cortical neurons. Attenuates dendritic spine elimination and enhances spine generation in DISC1 knockdown mice. Ameliorates autism-like behavioral symptoms in fragile X mental retardation 1 (Fmr1) knockout mice. Brain penetrant and orally bioavailable. Purity 98%. MW (observed): 513.39 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-(2,4-Dichlorophenyl)-8-ethyl-2-[[3-fluoro-4-(1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one |
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| Gene, Accession, CAS # | CAS: 1232030-35-1 |
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| Catalog # | 5190/10 |
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| Order / More Info | FRAX 486 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 27071060 |
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| 产品资料 |
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