| 产品详情 |
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| Product Name | PD 173074 |
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| Description | Selective FGFR1 and FGFR3 inhibitor (IC50 values are 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and > 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors. Suppresses cell proliferation in cell lines expressing mutated FGFR3 protein. Blocks tumor growth in H510 and H69 SCLC xenograft models. Purity 98%. MW (observed): 523.67 |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea |
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| Gene, Accession, CAS # | CAS: 219580-11-7 |
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| Catalog # | 3044/50 |
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| Order / More Info | PD 173074 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 22493675, 22553035, 22763448, 22791892, 22791896, 22988910, 23145076, 25156440, 25240927, 25884729, 25894690, 25973543, 26089912, 26138239, 26579384, 26837596, 27120163 |
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