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| Product Name | PD 98059 |
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| Description | Inhibitor of mitogen-activated protein kinase kinase (MKK/ MEK). Acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC50 = 2-7 μM). Inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines; causes G1 arrest by blocking p53-dependent p21 induction. Enhances embryonic stem cell self-renewal. Also available as part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™. Purity 98%. MW (observed): 267.28 |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one |
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| Gene, Accession, CAS # | CAS: 167869-21-8 |
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| Catalog # | 1213/50 |
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| Price | |
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| Order / More Info | PD 98059 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 12794003, 12871827, 15358610, 15531716, 16397234, 16627622, 17018141, 17068343, 17160007, 17409429, 17592023, 17666435, 17923483, 18079115, 18258605, 18446233, 18724384, 18768402, 18976694, 19255520, 19371341, 19547699, 19675232, 19723763, 19828633, 19906977, 20007592, 20427666, 20479872, 20724703, 21143600, 21440539, 21454669, 21483797, 21510868, 21551364, 21593322, 21672207, 21685895, 21715663, 21945811, 21995440, 22031657, 22451267, 22942754, 23052036, 23373701, 23593498, 23675999, 23754277, 23826343, 23967228, 24222778, 24227191, 24335212, 24915299, 25012653, 25056951, 25077525, 25243776, 25260613, 25275309, 25398056, 25481381, 25589756, 25744000, 25768340, 25936372, 26065826, 26074768, 26098771, 26251761, 26271343, 26414859, 26637332, 26642930, 27320041, 27520483, 27663973, 27876620, 28322749, 28476646, 28512295, 29187895 |
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