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| Product Name | Ro 3306 |
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| Description | ATP-competitive cyclin-dependent kinase 1 (cdk1) inhibitor (Ki values range from 35 to 240 nM depending on cdk1 binding partner). Also reported to inhibit other cdks (Ki values are 0.89-1.32, 0.03 and >2 μM for cdk2, cdk3 and cdk4, respectively). Induces G2/M phase cell cycle arrest and apoptosis. Downregulates the expression of antiapoptotic proteins such as Bcl-2 and survivin and enhances downstream p53 signaling in acute myeloid leukemia (AML). Purity 98%. MW (observed): 351.45 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone |
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| Gene, Accession, CAS # | CAS: 872573-93-8 |
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| Catalog # | 4181/10 |
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| Order / More Info | Ro 3306 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 23478441, 24740004, 25602147, 26293378, 26468278, 28607478 |
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