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| Product Name | IEM 1460 |
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| Description | Voltage-dependent open-channel blocker of AMPA receptors. Selective for GluR2 subunit-lacking (Ca2+-permeable) receptors over GluA2-containing receptors (IC50 values are 2.6 and 1102 μM, respectively). Selectively blocks fast spiking interneuron but not medium spiny projection neuron in mouse striatum. Also blocks NMDA receptor-mediated currents. Anticonvulsant in vivo. Purity 98%. MW (observed): 454.33 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N,N,H,-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminiumbromide hydrobromide |
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| Gene, Accession, CAS # | CAS: 121034-89-7 |
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| Catalog # | 1636/10 |
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| Order / More Info | IEM 1460 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 18524905, 19657020, 19956641, 21282008, 21694776, 22699894, 23136413, 23403695, 24030012, 25225096, 26370265, 26585043, 26758849, 26973464 |
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