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| Product Name | SB 431542 |
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| Description | Potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor/ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF-β-induced proliferation of human osteosarcoma cells. Replaces SOX2 in reprogramming of fibroblasts into iPSCs. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells. Inhibits TGF-β-induced EMT, migration, invasion and VEGF secretion in several human cancer cell lines. SB 431542 synthesized to cGMP guidelines also available.. Purity 99%. MW (observed): 384.39 |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide |
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| Gene, Accession, CAS # | CAS: 301836-41-9 |
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| Catalog # | 1614/50 |
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| Order / More Info | SB 431542 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 15781474, 16000588, 16251876, 16314481, 16510868, 16684517, 16778334, 16809784, 17010940, 17113264, 17121744, 17288590, 17376964, 17429065, 17692308, 18042803, 18043735, 18077689, 18234181, 18266973, 18339844, 18434375, 18504435, 18713620, 19098325, 19098895, 19223462, 19252484, 19276183, 19340291, 19363156, 19538467, 19605630, 19738024, 19806200, 19838175, 19839055, 19934330, 20081865, 20144602, 20195389, 20210627, 20339548, 20592473, 20610623, 20679341, 20844080, 21057545, 21148566, 21152098, 21257710, 21288898, 21330944, 21359200, 21440539, 21444674, 21453480, 21468017, 21508222, 21521871, 21525052, 21571225, 21909397, 22196728, 22269325, 22306606, 22415836, 22567022, 22615489, 22620718, 22643838, 22753106, 22860217, 22911885, 23055827, 23088614, 23110084, 23113900, 23122291, 23145076, 23169291, 23243310, 23316134, 23355677, 23437109, 23467611, 23507034, 23562599, 23584186, 23761168, 23792643, 23840342, 23858432, 23862100, 23863942, 23880763, 23907528, 23950932, 24013066, 24029687, 24043896, 24086284, 24145351, 24158517, 24162655, 24239350, 24244891, 24291815, 24370273, 24440272, 24445281, 24550394, 24555435, 24637302, 24651281, 24709321, 24803652, 24895131, 24925468, 25024431, 25064463, 25205843, 25266657, 25345855, 25392299, 25398695, 25422477, 25448007, 25448845, 25471520, 25654758, 25658089, 25658373, 25741001, 25745638, 25828472, 25866967, 25879629, 25884855, 25915126, 25954501, 25955532, 25970290, 26005811, 26059637, 26081042, 26104416, 26121747, 26136155, 26218671, 26220942, 26272509, 26278042, 26388286, 26395143, 26473351, 26481520, 26540589, 26549851, 26554899, 26573335, 26607280, 26713239, 26782058, 26812940, 26891705, 27320041, 27376469, 27378374, 27428650, 27531748, 27716510, 27783651, 27806135, 27835901, 27863501, 27899163, 27974704, 28071742, 28132833, 28139695, 28168444, 28178531, 28302086, 28462385, 28655839, 28886367, 28965766, 29396410, 29632371, 29979986, 29996941, 30573846, 30745031 |
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