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| Product Name | VH 298 |
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| Description | High-affinity inhibitor of E3 ubiquitin ligase VHL (Kd = 80-90 nM). Blocks interaction between VHL and HIF-α downstream of HIF-α hydroxylation, initiating hypoxic response. Results in time- and concentration-dependent accumulation of hydroxylated HIF-α, and upregulates mRNA and protein levels of HIF target genes, with similar transcriptional profile to hypoxia. Cell permeable. Negative control cis VH 298 also available. Purity 98%. MW (observed): 523.65 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
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| Gene, Accession, CAS # | CAS: 2097381-85-4 |
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| Catalog # | 6156/10 |
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| Price | |
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| Order / More Info | VH 298 from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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| 产品资料 |
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