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| Product Name | Paxilline |
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| Description | Potent blocker of high-conductance Ca2+-activated K+ (BKCa, KCa1.1) channels. Binds to the α-subunit of BKCa (Ki = 1.9 nM for block of currents in α-subunit-expressing oocytes) and enhances binding of charybdotoxin to BKCa channels in vascular smooth muscle. Also inhibits sarco/endoplasmic reticulum Ca2+-ATPase (IC50 = 5 - 50 μM). Purity 98%. MW (observed): 435.56 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a,7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-pyrano[2'',3'':5',6']benz[1',2':6,7]indeno[1,2-b]indol-3(4bH)-one |
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| Gene, Accession, CAS # | CAS: 57186-25-1 |
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| Catalog # | 2006/10 |
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| Order / More Info | Paxilline from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 15509733, 18495119, 18992727, 20592126, 20884759, 22331418, 22962016, 23174562, 23325318, 24312002, 24886877, 25172903, 25948259, 26019339, 26400949 |
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