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| Product Name | XE 991 dihydrochloride |
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| Description | Potent and selective blocker of KV7 (KCNQ) voltage-gated potassium channels. Blocks KV7.2+7.3 (KCNQ2+3)/ M-currents (IC50 = 0.6 - 0.98 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 0.75 μM) but is less potent against KV7.1/minK channels (IC50 = 11.1 μM). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo. Purity 99%. MW (observed): 449.37 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride |
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| Gene, Accession, CAS # | CAS: 122955-13-9 |
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| Catalog # | 2000/10 |
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| Order / More Info | XE 991 dihydrochloride from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 16056238, 16926279, 18048450, 18971466, 19144862, 19151245, 19202166, 19450820, 20016101, 20132415, 21228322, 21562284, 21740972, 21828176, 21951272, 22029713, 22218089, 22593734, 22870268, 23076110, 23554485, 23695859, 23977150, 25599691, 25904846, 26082693, 26113994, 26245971, 26578914, 27511837, 28483800, 29109270 |
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