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| Product Name | XMD 8-92 |
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| Description | ERK5 (BMK1) and BRD4 inhibitor (Kd values are 80 and 190 nM, respectively). Also inhibits DCAMKL2, PLK4 and TNK1 (Kd values are 190, 600 and 890 nM). Blocks growth factor-induced activation of cellular BMK1 and reduces BMK1 activity in in vitro kinase assays. Also reduces BMK1-dependent transactivating activity of MEF2C. Inhibits proliferation in a variety of cancer cell lines; blocks tumor cell proliferation and tumor-associated angiogenesis. Purity 98%. MW (observed): 474.55 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[[2-Ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,11-dihydro-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one |
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| Gene, Accession, CAS # | CAS: 1234480-50-2 |
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| Catalog # | 4132/10 |
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| Order / More Info | XMD 8-92 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 24762669, 25855966, 29416614 |
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