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| Product Name | Y-27632 dihydrochloride |
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| Description | Selective p160ROCK inhibitor (Ki values are 0.14, 26, 25 and > 250 μM for p160ROCK, PKC, PKA and MLCK respectively). Also inhibits PRK2 (IC50 = 600 nM). Smooth muscle relaxant and orally active in vivo. Increases survival rate of human embryonic stem (hES) cells and iPSC-BMECs undergoing cryopreservation. Also optimizes naïve human pluripotent stem cell growth and viability following naïve cell derivation from primed ESCs and iPSCs using naïve human stem cell medium (NHSM). Y-27632 synthesized to cGMP guidelines also available.. Purity 98%. MW (observed): 320.26 |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride |
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| Gene, Accession, CAS # | CAS: 129830-38-2 |
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| Catalog # | 1254/50 |
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| Order / More Info | Y-27632 dihydrochloride from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 11279053, 12011056, 12176736, 12225960, 12359716, 12522098, 12642376, 12773570, 14506264, 14532355, 14644769, 14769832, 15187088, 15806155, 15976312, 16595546, 16723500, 16809572, 16890527, 17160007, 17941977, 18536751, 18703661, 19088845, 19258396, 19325475, 19838175, 20336666, 20409712, 20717570, 20833361, 20858732, 21148427, 21152444, 21242312, 21342877, 21445393, 21518790, 21854845, 21860592, 22038049, 22385965, 22542618, 22723436, 22860217, 22879936, 22962324, 22981225, 23021998, 23055514, 23099485, 23257984, 23316134, 23395612, 23507034, 23536783, 23562876, 23576731, 23643533, 23665174, 23708000, 23738008, 23813963, 23843509, 23867565, 23897649, 24013066, 24088573, 24116978, 24122009, 24154490, 24172903, 24220295, 24291815, 24321451, 24607366, 24838915, 24843006, 24882515, 24930520, 24963846, 25137150, 25164814, 25232937, 25241748, 25342558, 25342560, 25366897, 25422477, 25499974, 25501034, 25505152, 25582222, 25608652, 25658373, 25663698, 25679761, 25680479, 25695512, 25702639, 25799239, 25804737, 25911094, 25965345, 26097378, 26102527, 26129894, 26139150, 26165921, 26207907, 26220942, 26272509, 26323721, 26395143, 26414184, 26451103, 26458176, 26473351, 26509098, 26527385, 26565809, 26573335, 26607951, 26677983, 26683376, 26732624, 26747941, 26748478, 26931404, 27320041, 27468699, 27583644, 27640816, 27716510, 27782124, 27824338, 27901489, 27906170, 28031255, 28139695, 28166224, 28178531, 28524846, 28777944, 28785084, 28800762, 28886367, 28965766, 29429961, 29979986, 29996941, 30745031 |
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