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| Product Name | LY 364947 |
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| Description | Selective inhibitor of TGF-β type-I receptor (TGF-β RI, TGFR-I, TβR-I, ALK-5) (IC50 values are 59, 400 and 1400 nM for TGR-β RI, TGF-β RII and MLK-7K respectively). Inhibits TGF-β-dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3) (IC50 values are 47 and 89 nM respectively). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay. Purity 99%. MW (observed): 272.31 |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-quinoline. HTS 466284 |
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| Gene, Accession, CAS # | CAS: 396129-53-6 |
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| Catalog # | 2718/1 |
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| Order / More Info | LY 364947 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 21546528, 21642622, 22880011, 23349840, 23748100, 24855276, 25723170, 25848047, 27586142, 27819283 |
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