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| Product Name | PD 0325901 |
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| Description | Potent MEK1 and MEK2 inhibitor. Inhibits MEK activity in mouse colon 26 cells (IC50 = 0.33 nM). Inhibits the growth of melanoma cell lines in vitro and in vivo; induces G1-phase cell cycle arrest and apoptosis in a mouse xenograft model. Also inhibits production of proangiogenic cytokines such as VEGF. Enhances generation of induced pluripotent stem cells (iPSCs). Orally active. Purity 99%. MW (observed): 482.19 |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide. PD325901 |
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| Gene, Accession, CAS # | CAS: 391210-10-9 |
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| Catalog # | 4192/50 |
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| Order / More Info | PD 0325901 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 22791892, 22911885, 25068130, 25323938, 25740845, 25775043, 26098448, 26642061, 26690966, 26780827, 27788485, 28257702, 28306514, 29358044, 29396410, 29632371 |
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