| 产品详情 |
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| Product Name | Embelin |
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| Description | Cell-permeable, non-peptide inhibitor of X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 μM in competition binding assay with Smac peptide); binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Inhibits cell growth, induces apoptosis and activates caspase-9 in prostate cancer cells (IC50 4 - 6 μM), but has a weaker effect on normal prostate cells (IC50 = 19 - 20 μM). Overcomes the protective effect of XIAP on apoptosis in XIAP-transfected Jurkat cells. Anti-tumor, analgesic and anti-inflammatory in vivo. Purity 98%. MW (observed): 294.39 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione |
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| Gene, Accession, CAS # | CAS: 550-24-3 |
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| Catalog # | 2156/10 |
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| Order / More Info | Embelin from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 23446637 |
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| 产品资料 |
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