| 产品详情 |
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| Product Name | PF 04418948 |
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| Description | Potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 μM. Inhibits PGE2-induced increases in intracellular cAMP; reverses PGE2-invoked relaxation of mouse trachea (IC50 = 2.7 nM). Purity 99%. MW (observed): 409.41 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-(4-Fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-3-azetidinecarboxylic acid |
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| Gene, Accession, CAS # | CAS: 1078166-57-0 |
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| Catalog # | 4818/10 |
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| Price | |
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| Order / More Info | PF 04418948 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 26508788, 26826430, 27812120, 30397349 |
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| 产品资料 |
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