| 产品详情 |
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| Product Name | MRK 016 |
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| Description | GABAA receptor inverse agonist selective for the α5-subtype (EC50 = 3 nM). Exhibits affinity at benzodiazepine binding site of recombinant human GABAA receptors (Ki values are 0.77 nM, 0.83 nM, 0.85 nM and 1.4 nM for α3-, α1-, α2-, and α5-containing respectively). Increases long-term potentiation (LTP) in mouse hippocampal slices. Exhibits no anxiogenic or proconvulsant activity. Purity 98%. MW (observed): 368.39 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-(1,1-Dimethylethyl)-7-(5-methyl-3-isoxazolyl)-2-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-pyrazolo[1,5-d][1,2,4]triazine |
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| Gene, Accession, CAS # | CAS: 342652-67-9 |
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| Catalog # | 3817/10 |
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| Order / More Info | MRK 016 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 28275719 |
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| 产品资料 |
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