| 产品详情 |
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| Product Name | MRK 560 |
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| Description | γ-secretase inhibitor; inhibits proteolytic cleavage of amyloid precursor protein (APP) over the Notch pathway. Reduces levels of Aβ in the brain (inhibits Aβ40 and Aβ42 in SH-SY5Y neuroblastoma cells with an IC50 of 0.65 nM); attenuates plaque deposition. Orally bioavailable. Purity 99%. MW (observed): 517.92 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide |
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| Gene, Accession, CAS # | CAS: 677772-84-8 |
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| Catalog # | 4000/10 |
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| Price | |
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| Order / More Info | MRK 560 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 24200971, 25540024, 27103572 |
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| 产品资料 |
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