| 产品详情 |
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| Antigenic Specificity | PARP |
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| Clone | 2B6 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1κ |
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| Format | Protein G purified |
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| Size | 100 µg |
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| Concentration | 1 mg/ml |
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| Applications | WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Monoclonal antibody to detect PARP in human samples. PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like Caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis. |
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| Immunogen | A synthetic peptide corresponding to residues before the cleavage site of human PARP-1 was used as immunogen. This antibody recognizes full-length form of PARP and PARP-1 only. |
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| Other Names | PARP1, ADPRT, PPOL, NAD(+) ADP-ribosyltransferase 1 |
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| Gene, Accession # | Gene ID: 142, Accession: P09874 |
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| Catalog # | A1109-100 |
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| Price | |
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| Order / More Info | PARP Antibody from BIOVISION, INC. |
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| Product Specific References | n/a |
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