| 产品详情 |
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| Antigenic Specificity | KLRK1 / CD314 / NKG2D |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | peroxidase (HRP) conjugate |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | ELISA |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | KLRK1 / CD314 / NKG2D Antibody (HRP) LS-C499206. Specificity: Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. |
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| Immunogen | Recombinant Human NKG2-D type II integral membrane protein (73-216AA) |
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| Other Names | KLRK1, D12S2489E, CD314 antigen, KLR, NK cell receptor D, NKG2D, NKG2-D, NKG2-D-activating NK receptor, CD314 |
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| Gene, Accession # | KLRK1, Gene ID: 22914 |
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| Catalog # | LS-C499206 |
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| Price | |
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| Order / More Info | KLRK1 / CD314 / NKG2D Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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