| 产品标题 |
产品货号 |
产品规格 |
厂家 |
| Linagliptin - BI 1356 | Axon 2354
CAS [668270-12-0]
MF C25H28N8O2MW 472.54
Purity:
99%
Optical purity:
Optically pure
Soluble in DMSO
Description
Competitive and highly selective dipeptidyl peptidase (DPP)-4 inhibitor (IC50 value ca. 1 nM in vitro) with superior potency and long duration of action in vivo. Linagliptin is ≥10,000-fold more selective for DPP-4 than DPP-8, DPP-9, amino-peptidases N and P, prolyloligopeptidase, trypsin, plasmin, and thrombin and is 90-fold more selective than for fibroblast activation protein in vitro. Approved drug for treatment of type 2 diabetes with long-lasting effects on glucose tolerance through control of GLP-1 and insulin.
References
Certificates
Categories
Extra info
J. Rungby. Inhibition of dipeptidyl peptidase 4 by BI-1356, a new drug for the treatment of beta-cell failure in type 2 diabetes. Exp.Opin. Investig. Drugs. 2009, 18, 835-838.
L. Thomas et al. (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor,…. J. Pharmacol. Exp. Ther. 2008, 325, 175-182.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
Diabetes & Metabolism
DPP4
EC 3.4.14.5
Competitive and highly selective dipeptidyl peptidase (DPP)-4 inhibitor
Chemical name
(R)-8-(3-aminopiperidin-1-yl)-7-(but-2-ynyl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione
Parent CAS No.
[668270-12-0]
Order
Size
Unit Price
Stock
10 mg
€90.00
In Stock | | axonmedchem |
| SCH 58261 | Axon 1253
CAS [160098-96-4]
MF C18H15N7OMW 345.36
Purity:
99%
Soluble in DMSO
Description
Highly selective and potent A2A adenosine receptor antagonist.
KEYWORDS: SCH 58261 | supplier | A2A antagonist | SCH58261 | SCH-58261 | CAS [160098-96-4] | Adenosine | A2A | Antagonist | Receptors | | axonmedchem |
| Chloroadenosine, 2- - CADO | Axon 1190
CAS [146-77-0]
MF C10H12ClN5O4MW 301.69
Purity:
99%
Soluble in DMSO
Description
A1 and A2A adenosine receptor agonist. The compound has a potent effect on the peripheral and central nervous system
References
Certificates
Categories
Extra info
JK Hirsh and EM Silinsky. Inhibition of spontaneous acetylcholine secretion by 2-chloroadenosine as revealed by a protein kinase inhibitor at the mouse neuromuscular junction. Br J Pharmacol. 2002, 135, 1897–1902
MH Pourgholami et al. Intra-amygdala infusion of 2-chloroadenosine suppresses amygdala-kindled seizures. Brain Res. 1997, 775, 37.
AS Abdul-Ghani et al. The protective effect of 2-chloroadenosine against the development of amygdala kindling and on amygdala-kindled seizures. Eur J Pharmacol. 1997, 326(1), 7-14.
Certificate of Analysis
Material Safety Data Sheet
Cardiovascular
CNS
A1
A2A
A18
Adenosine A1 and A2A agonist
Chemical name
(2R,3R,4S,5R)-2-(6-Amino-2-chloro-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol
Parent CAS No.
[146-77-0]
Order
Size
Unit Price
Stock
50 mg
€65.00
In Stock | | axonmedchem |
| Adenosine amine congener - ADAC | Axon 1188
CAS [96760-69-9]
MF C28H32N8O6MW 576.60
Purity:
98%
Moderately soluble in DMSO
Description
Potent A1 adenosine receptor agonist
References
Certificates
Categories
Extra info
D Blum et al. The Adenosine A1 Receptor Agonist Adenosine Amine Congener Exerts a Neuroprotective Effect against the Development of Striatal Lesions and Motor Impairments in the 3-Nitropropionic Acid Model of Neurotoxicity. J. Neurosci. 2002, 22, 9122.
Certificate of Analysis
Material Safety Data Sheet
Cardiovascular
CNS
A1
A18
Adenosine A1 agonist
Chemical name
N-{4-[(2-Amino-ethylcarbamoyl)-methyl]-phenyl}-2-{4-[9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-phenyl}-acetamide
Parent CAS No.
[96760-69-9]
Order
Size
Unit Price
Stock
10 mg
€125.00
In Stock | | axonmedchem |
| N 0425 hydrochloride, (-)- - N-methyl-N-propargyl-2-aminotetralin hydrochloride, (-)- | Axon 1063
CAS [98640-73-4]
MF C14H17N.HClMW 235.75
Purity:
99%
Optical purity:
>98% ee
Soluble in water
Description
Potent monoamine oxidase (MAO) inhibitor; (-)-N 0425 is equipotent for MAO-A and MAO-B in vitro. The racemate N 0425 (Axon 1022) and the other enantiomer (+)-N 0425 (Axon 1062) are available as well.
References
Certificates
Categories
Extra info
J. Sterling et al. (R)(+)-N-propargyl-1-aminoindan (rasagiline) and derivatives: highly selective and potent inhibitors of monoamine oxidase B. J. Neural. Transm. Suppl. 1998, 52, 301-305.
B Hazelhoff et al. The neuropharmacological profile of N-methyl-N-propargyl-2-aminotetralin: a potent monoamine oxidase inhibitor. Naunyn-Schmiedeberg's Arch. Pharmacol. 1985, 330, 50-58.
B. Hazelhoff et al. N-methyl,N-propargyl-2-aminotetralins:novel dopamine agonists with monoamine oxidase inhibiting properties. Eur. J. Pharmacol. 1985, 109, 229-240.
Certificate of Analysis
Material Safety Data Sheet
CNS
MAO
D2
D3
D4
D1
EC 1.4.3.4
MAO inhibitor
Chemical name
(-)-Methyl-prop-2-ynyl-(1,2,3,4-tetrahydro-naphthalen-2-yl)-amine hydrochloride
Parent CAS No.
[98640-73-4]
Order
Size
Unit Price
Stock
5 mg
€135.00
In Stock | | axonmedchem |
| N 0425 hydrochloride, (+)- - N-methyl-N-propargyl-2-aminotetralin hydrochloride, (+)- | Axon 1062
CAS [98640-74-5]
MF C14H17N.HClMW 235.75
Purity:
99%
Optical purity:
>98% ee
Soluble in water
Description
Potent monoamine oxidase (MAO) inhibitor; (+)-N 0425 is ten times more potent in inhibiting MAO-B than MAO-A under in vitro conditions. The racemate N 0425 (Axon 1022) and the other enantiomer (-)-N 0425 (Axon 1063) are available as well.
References
Certificates
Categories
Extra info
J. Sterling et al. (R)(+)-N-propargyl-1-aminoindan (rasagiline) and derivatives: highly selective and potent inhibitors of monoamine oxidase B. J. Neural. Transm. Suppl. 1998, 52, 301-305.
B Hazelhoff et al. The neuropharmacological profile of N-methyl-N-propargyl-2-aminotetralin: a potent monoamine oxidase inhibitor. Naunyn-Schmiedeberg's Arch. Pharmacol. 1985, 330, 50-58.
B. Hazelhoff et al. N-methyl,N-propargyl-2-aminotetralins:novel dopamine agonists with monoamine oxidase inhibiting properties. Eur. J. Pharmacol. 1985, 109, 229-240.
Certificate of Analysis
Material Safety Data Sheet
CNS
MAO
D2
D3
D4
D1
EC 1.4.3.4
MAO inhibitor
Chemical name
(+)-Methyl-prop-2-ynyl-(1,2,3,4-tetrahydro-naphthalen-2-yl)-amine hydrochloride
Parent CAS No.
[98640-74-5]
Order
Size
Unit Price
Stock
5 mg
€135.00
In Stock | | axonmedchem |
| N 0425 hydrochloride - N-methyl-N-propargyl-2-aminotetralin hydrochloride | Axon 1022
CAS [78621-26-8]
MF C14H17N.HClMW 235.75
Purity:
99%
Soluble in water and DMSO
Description
Potent monoamine oxidase (MAO) inhibitor; Racemic N 0425 is equipotent for MAO-A and MAO-B in vitro. Both enantiomers are available as well ((+)-N 0425 (Axon 1062) and (-)-N 0425 (Axon 1063)).
References
Certificates
Categories
Extra info
J. Sterling et al. (R)(+)-N-propargyl-1-aminoindan (rasagiline) and derivatives: highly selective and potent inhibitors of monoamine oxidase B. J. Neural. Transm. Suppl. 1998, 52, 301-305.
B Hazelhoff et al. The neuropharmacological profile of N-methyl-N-propargyl-2-aminotetralin: a potent monoamine oxidase inhibitor. Naunyn-Schmiedeberg's Arch. Pharmacol. 1985, 330, 50-58.
B. Hazelhoff et al. N-methyl,N-propargyl-2-aminotetralins:novel dopamine agonists with monoamine oxidase inhibiting properties. Eur. J. Pharmacol. 1985, 109, 229-240.
Certificate of Analysis
Material Safety Data Sheet
CNS
MAO
D2
D3
D4
D1
EC 1.4.3.4
MAO inhibitor
Chemical name
Methyl-prop-2-ynyl-(1,2,3,4-tetrahydro-naphthalen-2-yl)-amine hydrochloride
Parent CAS No.
[96333-07-2]
Order
Size
Unit Price
Stock
10 mg
€95.00
In Stock | | axonmedchem |
| Piribedil | Axon 1198
CAS [3605-01-4]
MF C16H18N4O2MW 298.34
Purity:
99%
No solubility data
Description
Direct dopamine agonist, with affinity for subtypes: D3 > D2 >> D1; an anti-parkinson drug marketed as Trivastal retard 50
References
Certificates
Categories
Extra info
Cagnotto et al. In vitro affinity of piribedil for dopamine D3 receptor subtypes, an autoradiographic study. Eur. J. Pharmacol. 1996, 313, 63.
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
D3
D1
A17
Dopamine agonist
Chemical name
2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-pyrimidine
Parent CAS No.
[3605-01-4]
Order
Size
Unit Price
Stock
10 mg
€75.00
In Stock | | axonmedchem |
| MPTP hydrochloride | Axon 1075
CAS [23007-85-4]
MF C12H15N.HClMW 209.72
Purity:
99%
Soluble in water
Description
A dopaminergic neurotoxin that causes permanent symptoms of Parkinson's disease by killing certain neurons in the substantia nigra of the brain. Useful tool compound for Parkinson's disease related studies.
Remarks | | axonmedchem |
| Norapomorphine hydrobromide, R(-)- | Axon 1160
CAS [115017-61-3]
MF C16H15NO2.HBrMW 334.21
Purity:
98%
Optical purity:
>98% ee
Soluble in 0.1N HCl(aq) and DMSO
Description
Potent dopamine receptor agonist
References
Certificates
Categories
Extra info
Anlezark et al. Comparative assessment of dopamine agonist aporphines as anticonvulsants in two models of reflex epilepsy. Psychopharmacology 1983, 81, 135.
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
D3
D4
D1
A17
Dopamine agonist
Chemical name
(R)-5,6,6a,7-Tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol hydrobromide
Parent CAS No.
[478-76-2]
Order
Size
Unit Price
Stock
5 mg
€125.00
In Stock | | axonmedchem |
| Dopamine hydrobromide, N,N-dibutyl | Axon 1061
CAS [65273-67-8]
MF C16H27NO2.HBrMW 346.30
Purity:
99%
Soluble in water and DMSO
Description
Dopamine receptor agonist
References
Certificates
Categories
Extra info
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
D3
D4
D1
A17
Dopamine agonist
Chemical name
4-(2-Dibutylamino-ethyl)-benzene-1,2-diol hydrobromide
Parent CAS No.
[68671-30-7]
Order
Size
Unit Price
Stock
10 mg
€95.00
In Stock | | axonmedchem |
| TL 99 hydrobromide | Axon 1060
CAS [62421-56-1]
MF C12H17NO2.HBrMW 288.18
Purity:
98%
Soluble in water and DMSO
Description
A putative dopamine autoreceptor agonist
References
Certificates
Categories
Extra info
J.M. Kitzen et al. Pharmacology of 6,7-dihydroxy-2-dimethylaminotetralin (TL-99). I. Cardiovascular activity in the dog and cat. J. Pharmacol. Exp. Ther. 1998, 206, 2, 239-247.
J.E. Martin et al. Pharmacological profiles of the putative dopamine autoreceptor agonists 3-PPP and TL-99. Eur. J. Pharmacol. 1981, 76(1):15-23.
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
D3
D4
D1
A17
Dopamine agonist
Chemical name
6-Dimethylamino-5,6,7,8-tetrahydro-naphthalene-2,3-diol hydrobromide
Parent CAS No.
[66543-77-9]
Order
Size
Unit Price
Stock
5 mg
€95.00
In Stock | | axonmedchem |
| Aminotetraline hydrochloride, (R)-(+)-5-Methoxy-2- | Axon 1049
CAS [58349-15-8]
MF C11H15NO.HClMW 213.70
Purity:
95%
Optical purity:
>98% ee
Soluble in water and DMSO
Description
Dopamine receptor agonist
References
Certificates
Categories
Extra info
CNS
D2
D3
D4
D1
A17
Dopamine agonist
Chemical name
(R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride
Parent CAS No.
[105086-92-8]
Inquire | | axonmedchem |
| Aminotetraline hydrochloride, 5-Methoxy-2- - SKF 87967 hydrochloride | Axon 1048
CAS [3880-88-4]
MF C11H15NO.HClMW 213.70
Purity:
98%
No solubility data
Description
Dopamine receptor agonist
References
Certificates
Categories
Extra info
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
D3
D4
D1
A17
Dopamine agonist
Chemical name
5-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride
Parent CAS No.
[4018-91-1]
Inquire | | axonmedchem |
| Aminotetraline hydrochloride, (S)-(-)-5-Methoxy-2- | Axon 1050
CAS [58349-17-0]
MF C11H15NO.HClMW 213.70
Purity:
100%
Optical purity:
>98% ee
Soluble in water and DMSO
Description
Dopamine receptor agonist
References
Certificates
Categories
Extra info
L.A. van Vliet et al. Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity. J. Med. Chem. 1996, 39, 4233-4237.
Q.H. Ye et al. Conformationally restricted and conformationally defined tyramine analogues as inhibitors of phenylethanolamine N-methyltransferase. J. Med. Chem. 1989, 32, 478-486.
E.J. Homan et al. Synthesis and Pharmacology of the enantiomers of the potential atypical antipsychotic agents 5-OMe-BPAT and 5-OMe-(2,6-di-OMe)-BPAT. Bioorg Med Chem. 1999 Jul;7(7):1263-71.
J.D. McDermed et al. Synthesis and dopaminergic activity of (zk)-, (+)-, and (-)-2-Dipropyiamino-5-hydroxy- 1,2,3,4-tetrahydronaphthalene. J Med Chem 1976,19(4), 547-549.
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
D3
D4
D1
A17
Dopamine agonist
Chemical name
(S)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride
Parent CAS No.
[105086-80-4]
Order
Size
Unit Price
Stock
10 mg
€145.00
In Stock | | axonmedchem |
| Aminotetraline hydrochloride, (S)-7-Methoxy-2- - (S)-7-MeO-DPAT hydrochloride | Axon 1056
CAS [158223-16-6]
MF C11H15NO.HClMW 213.70
Purity:
97%
Optical purity:
>98% ee
Soluble in water and DMSO
Description
Building Block; unknown pharmacology
References
Certificates
Categories
Extra info
L.A. van Vliet et al. Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity. J. Med. Chem. 1996, 39, 4233-4237.
Q.H. Ye et al. Conformationally restricted and conformationally defined tyramine analogues as inhibitors of phenylethanolamine N-methyltransferase. J. Med. Chem. 1989, 32, 478-486.
Certificate of Analysis
Material Safety Data Sheet
CNS
Non Selective
Building Block; unknown pharmacology
Chemical name
(S)-7-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride
Parent CAS No.
[121216-42-0]
Order
Size
Unit Price
Stock
5 mg
€125.00
In Stock | | axonmedchem |
| Aminotetraline hydrochloride, (R)-7-Methoxy-2- - (R)-7-MeO-DPAT hydrochloride | Axon 1055
CAS [170638-05-8]
MF C11H15NO.HClMW 213.70
Purity:
99%
Optical purity:
>98% ee
Soluble in water and DMSO
Description
Dopamine receptor agonist
References
Certificates
Categories
Extra info
L.A. van Vliet et al. Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity. J. Med. Chem. 1996, 39, 4233-4237.
Q.H. Ye et al. Conformationally restricted and conformationally defined tyramine analogues as inhibitors of phenylethanolamine N-methyltransferase. J. Med. Chem. 1989, 32, 478-486.
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
D3
D4
D1
A17
Dopamine agonist
Chemical name
(R)-7-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride
Parent CAS No.
[121216-43-1]
Order
Size
Unit Price
Stock
5 mg
€125.00
In Stock | | axonmedchem |
| Dihydro-2H-1-benzopyran-8-ol hydrochloride, 3-(Dipropylamino)-3,4- | Axon 1047
CAS [109140-45-6]
MF C15H23NO2.HClMW 285.81
Purity:
98%
No solubility data
Description
Dopamine receptor agonist
References
Certificates
Categories
Extra info
CNS
D2
D3
D4
D1
A17
Dopamine agonist
Chemical name
3-Dipropylamino-chroman-8-ol hydrochloride
Parent CAS No.
[112904-74-2]
Inquire | | axonmedchem |
| Aminotetraline hydrochloride, (S)-(-)-8-Methoxy-2- | Axon 1059
CAS [197446-42-7]
MF C11H15NO.HClMW 213.70
Purity:
98%
Optical purity:
>98% ee
No solubility data
Description
Building Block; 5-HT1A agonist
References
Certificates
Categories
Extra info
L.A. van Vliet et al. Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity. J. Med. Chem. 1996, 39, 4233-4237.
Q.H. Ye et al. Conformationally restricted and conformationally defined tyramine analogues as inhibitors of phenylethanolamine N-methyltransferase. J. Med. Chem. 1989, 32, 478-486.
CNS
5-HT1A
A19
Non Selective
Building Block; 5-HT1A agonist
Chemical name
(S)-8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride
Parent CAS No.
[127253-44-5]
Inquire | | axonmedchem |
| Aminotetraline hydrochloride, (R)-(+)-8-Methoxy-2- | Axon 1058
CAS [119363-61-0]
MF C11H15NO.HClMW 213.70
Purity:
98%
Optical purity:
>98% ee
No solubility data
Description
Building Block; 5-HT1A agonist
References
Certificates
Categories
Extra info
L.A. van Vliet et al. Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity. J. Med. Chem. 1996, 39, 4233-4237.
Q.H. Ye et al. Conformationally restricted and conformationally defined tyramine analogues as inhibitors of phenylethanolamine N-methyltransferase. J. Med. Chem. 1989, 32, 478-486.
CNS
5-HT1A
A19
Non Selective
Building Block; 5-HT1A agonist
Chemical name
(R)-8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride
Parent CAS No.
[127165-18-8]
Inquire | | axonmedchem |
| Aminotetraline hydrochloride, 8-Methoxy-2- | Axon 1057
CAS [3880-76-0]
MF C11H15NO.HClMW 213.70
Purity:
98%
No solubility data
Description
Building Block; 5-HT1A agonist
References
Certificates
Categories
Extra info
L.A. van Vliet et al. Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity. J. Med. Chem. 1996, 39, 4233-4237.
Q.H. Ye et al. Conformationally restricted and conformationally defined tyramine analogues as inhibitors of phenylethanolamine N-methyltransferase. J. Med. Chem. 1989, 32, 478-486.
CNS
5-HT1A
A19
Non Selective
Building Block; 5-HT1A agonist
Chemical name
8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride
Parent CAS No.
[3880-77-1]
Inquire | | axonmedchem |
| Aminotetraline hydrochloride, (S)-6-Methoxy-2- - Tetrahydro-6-methoxy-2-naphthalenamine hydrochloride, (2S)-1,2,3,4- | Axon 1053
CAS [1229244-88-5 ]
MF C11H15NO.HClMW 213.70
Purity:
96%
Optical purity:
>98% ee
Soluble in water and DMSO
Description
Building Block; unknown pharmacology
References
Certificates
Categories
Extra info
Certificate of Analysis
Material Safety Data Sheet
CNS
Non Selective
Building Block; unknown pharmacology
Chemical name
(S)-6-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride
Parent CAS No.
[177017-69-5]
Order
Size
Unit Price
Stock
5 mg
€125.00
In Stock | | axonmedchem |
| Aminotetraline hydrochloride, (R)-6-Methoxy-2- - Tetrahydro-6-methoxy-2-naphthalenamine hydrochloride, (2R)-1,2,3,4- | Axon 1052
CAS [1229244-90-9 ]
MF C11H15NO.HClMW 213.70
Purity:
99%
Optical purity:
>98% ee
Soluble in water and DMSO
Description
Building Block; unknown pharmacology
References
Certificates
Categories
Extra info
Certificate of Analysis
Material Safety Data Sheet
CNS
Non Selective
Building Block; unknown pharmacology
Chemical name
(R)-6-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride
Parent CAS No.
[177017-68-4]
Order
Size
Unit Price
Stock
5 mg
€125.00
In Stock | | axonmedchem |
| Aminotetraline hydrochloride, 5,6-Dimethoxy-2- | Axon 1042
CAS [21489-75-8]
MF C12H17NO2.HClMW 243.73
Purity:
98%
No solubility data
Description
Building Block; unknown pharmacology
References
Certificates
Categories
Extra info
A.S. Horn et al. Facile syntheses of potent dopaminergic argonists and their effect on neurotransmitter release. J. Med. Chem. 1978, 21, 825-828.
B. Costall et al. Dyskinetic phenomena caused by the intrastriatal injection of phenylethylamine, phenylpiperazine, tetrahydroisoquinoline and tetrahydronaphthalene derivatives in the guinea pig. Eur. J. Pharmacol. 1975, 31, 94-109.
S.A. Doggrell et al. Effects of drugs on the accumulation and spontaneous release of noradrenaline in the rat anococcygeus muscle. Br. J. Pharmacol. 1978, 63, 465-470.
CNS
Non Selective
Building Block; unknown pharmacology
Chemical name
5,6-Dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride
Parent CAS No.
[21489-50-9]
Inquire | | axonmedchem |
| Aminotetraline hydrochloride, (S)-8-Methoxy-N-propyl-2- | Axon 1034
CAS [78095-35-9]
MF C14H21NO.HClMW 255.78
Purity:
98%
Optical purity:
>98% ee
Soluble in DMSO
Description
Building Block; unknown pharmacology
References
Certificates
Categories
Extra info
L.A. van Vliet et al. Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity. J. Med. Chem. 1996, 39, 4233-4237.
A.S. Horn et al. Facile syntheses of potent dopaminergic argonists and their effect on neurotransmitter release. J. Med. Chem. 1978, 21, 825-828.
Certificate of Analysis
Material Safety Data Sheet
CNS
Non Selective
Building Block; unknown pharmacology
Chemical name
((S)-8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propyl-amine hydrochloride
Parent CAS No.
[133267-79-5]
Order
Size
Unit Price
Stock
25 mg
€225.00
In Stock | | axonmedchem |
| Aminotetraline hydrochloride, (R)-8-Methoxy-N-propyl-2- | Axon 1033
CAS [78095-32-6]
MF C14H21NO.HClMW 255.78
Purity:
98%
Optical purity:
>98% ee
Soluble in DMSO
Description
Building Block; unknown pharmacology
References
Certificates
Categories
Extra info
L.A. van Vliet et al. Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity. J. Med. Chem. 1996, 39, 4233-4237.
A.S. Horn et al. Facile syntheses of potent dopaminergic argonists and their effect on neurotransmitter release. J. Med. Chem. 1978, 21, 825-828.
Certificate of Analysis
Material Safety Data Sheet
CNS
Non Selective
Building Block; unknown pharmacology
Chemical name
((R)-8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propyl-amine hydrochloride
Parent CAS No.
[81185-23-1]
Order
Size
Unit Price
Stock
25 mg
€225.00
In Stock | | axonmedchem |
| Aminotetraline hydrochloride, 8-Methoxy-N-propyl-2- | Axon 1032
CAS [87394-71-6]
MF C14H21NO.HClMW 255.78
Purity:
98%
No solubility data
Description
Building Block; unknown pharmacology
References
Certificates
Categories
Extra info
CNS
Non Selective
Building Block; unknown pharmacology
Chemical name
(8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propyl-amine hydrochloride
Parent CAS No.
[3902-22-5]
Inquire | | axonmedchem |
| Aminotetraline hydrochloride, (S)-(-)-7-Methoxy-N-propyl-2- | Axon 1031
CAS [93503-09-4]
MF C14H21NO.HClMW 255.78
Purity:
98%
Optical purity:
>98% ee
No solubility data
Description
Building Block; unknown pharmacology
References
Certificates
Categories
Extra info
CNS
Non Selective
Building Block; unknown pharmacology
Chemical name
((S)-7-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propyl-amine hydrochloride
Parent CAS No.
[161873-80-9]
Order
Size
Unit Price
Stock
25 mg
€225.00
In Stock | | axonmedchem |
| Aminotetraline hydrochloride, (R)-(+)-7-Methoxy-N-propyl-2- | Axon 1030
CAS [93503-08-3]
MF C14H21NO.HClMW 255.78
Purity:
97%
Optical purity:
>98% ee
Soluble in water
Description
Building Block; unknown pharmacology
References
Certificates
Categories
Extra info
Certificate of Analysis
Material Safety Data Sheet
CNS
Miscellaneous
Non Selective
Building Block; unknown pharmacology
Chemical name
((R)-7-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propyl-amine hydrochloride
Parent CAS No.
[161873-84-3]
Order
Size
Unit Price
Stock
25 mg
€225.00
In Stock | | axonmedchem |
| Aminotetraline hydrochloride, 7-Methoxy-N-propyl-2- | Axon 1029
CAS [93601-93-5]
MF C14H21NO.HClMW 255.78
Purity:
98%
No solubility data
Description
Building Block; unknown pharmacology
References
Certificates
Categories
Extra info
CNS
Non Selective
Building Block; unknown pharmacology
Chemical name
(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propyl-amine hydrochloride
Parent CAS No.
[148258-42-8]
Inquire | | axonmedchem |
| Aminotetraline hydrochloride, 6-Methoxy-N-propyl-2- | Axon 1028
CAS [69788-83-6]
MF C14H21NO.HClMW 255.78
Purity:
98%
No solubility data
Description
Building Block; unknown pharmacology
References
Certificates
Categories
Extra info
CNS
Non Selective
Building Block; unknown pharmacology
Chemical name
(6-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propyl-amine hydrochloride
Parent CAS No.
[82763-23-3]
Inquire | | axonmedchem |
| Aminotetraline hydrobromide, 6,7-Dihydroxy-2- - ADTN, 6,7- | Axon 1045
CAS [13575-86-5]
MF C10H13NO2.HBrMW 260.13
Purity:
99%
Soluble in water and DMSO
Description
Dopamine receptor agonist.
KEYWORDS: 6,7-ADTN | supplier | DA agonist | ADTN, 6,7- | ADTN | CAS [13575-86-5] | [53463-78-8] | Dopamine | D1 | D2 | D3 | D4 | Agonist | Receptors | | axonmedchem |
| Aminotetraline hydrochloride, 7-Methoxy-2- | Axon 1054
CAS [3880-78-2]
MF C11H15NO.HClMW 213.70
Purity:
98%
No solubility data
Description
Building Block; unknown pharmacology
References
Certificates
Categories
Extra info
L.A. van Vliet et al. Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity. J. Med. Chem. 1996, 39, 4233-4237.
Q.H. Ye et al. Conformationally restricted and conformationally defined tyramine analogues as inhibitors of phenylethanolamine N-methyltransferase. J. Med. Chem. 1989, 32, 478-486.
CNS
Non Selective
Building Block; unknown pharmacology
Chemical name
7-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride
Parent CAS No.
[4003-89-8]
Inquire | | axonmedchem |
| Aminotetraline hydrobromide, 5,6-Dihydroxy-2- - ADTN, 5,6- | Axon 1044
CAS [37096-30-3]
MF C10H13NO2.HBrMW 260.13
Purity:
98%
No solubility data
Description
Dopamine receptor agonist
References
Certificates
Categories
Extra info
A.S. Horn et al. Facile syntheses of potent dopaminergic argonists and their effect on neurotransmitter release. J. Med. Chem. 1978, 21, 825-828.
B. Costall et al. Dyskinetic phenomena caused by the intrastriatal injection of phenylethylamine, phenylpiperazine, tetrahydroisoquinoline and tetrahydronaphthalene derivatives in the guinea pig. Eur. J. Pharmacol. 1975, 31, 94-109.
S.A. Doggrell et al. Effects of drugs on the accumulation and spontaneous release of noradrenaline in the rat anococcygeus muscle. Br. J. Pharmacol. 1978, 63, 465-470.
CNS
D2
D3
D4
D1
A17
Dopamine agonist
Chemical name
6-Amino-5,6,7,8-tetrahydro-naphthalene-1,2-diol hydrobromide
Parent CAS No.
[21489-74-7]
Inquire | | axonmedchem |
| Aminotetraline hydrobromide, 6,7-Dimethoxy-2- | Axon 1043
CAS [40069-26-9]
MF C12H17NO2.HBrMW 288.18
Purity:
99%
Soluble in water
Description
Dopamine receptor agonist
References
Certificates
Categories
Extra info
A.S. Horn et al. Facile syntheses of potent dopaminergic argonists and their effect on neurotransmitter release. J. Med. Chem. 1978, 21, 825-828.
B. Costall et al. Dyskinetic phenomena caused by the intrastriatal injection of phenylethylamine, phenylpiperazine, tetrahydroisoquinoline and tetrahydronaphthalene derivatives in the guinea pig. Eur. J. Pharmacol. 1975, 31, 94-109.
S.A. Doggrell et al. Effects of drugs on the accumulation and spontaneous release of noradrenaline in the rat anococcygeus muscle. Br. J. Pharmacol. 1978, 63, 465-470.
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
D3
D4
D1
A17
Non Selective
Dopamine agonist
Chemical name
6,7-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrobromide
Parent CAS No.
[67445-12-9]
Order
Size
Unit Price
Stock
10 mg
€125.00
In Stock | | axonmedchem |
| N 0734 hydrochloride | Axon 1041
CAS [102121-01-7]
MF C19H25NOS.HClMW 351.93
Purity:
99%
Moderately soluble in water
Description
Potent and selective dopamine receptor agonist; derivative of Rotigotine (N-0437, Axon 1038); * N-0734, N-0434 ((±)-PPHT, Axon 1035) and N-0437 are potent and selective DA agonists that lack significant α 2 activity
References
Certificates
Categories
Extra info
J van der Weide et al. Pharmacological profiles of three new, potent and selective dopamine receptor agonists: N-0434, N-0437 and N-0734. Eur. J. Pharmacol. 1986, 125, 273-282.
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
D3
D4
D1
A17
Dopamine agonist
Chemical name
6-[Propyl-(2-thiophen-3-yl-ethyl)-amino]-5,6,7,8-tetrahydro-naphthalen-1-ol hydrochloride
Parent CAS No.
[102121-00-6]
Order
Size
Unit Price
Stock
5 mg
€115.00
In Stock | | axonmedchem |
| Rotigotine - N 0923 | Axon 1040
CAS [99755-59-6]
MF C19H25NOSMW 315.47
Purity:
99%
Optical purity:
99% ee
Soluble in DMSO
Description
Dopamine receptor D2 and D3 agonist, more active enantiomer of N-0437 (Axon 1038) vs opposite (R)-enantiomer N-0924 (Axon 1039)
References
Certificates
Categories
Extra info
J van der Weide et al. Pharmacological profiles of three new, potent and selective dopamine receptor agonists: N-0434, N-0437 and N-0734. Eur. J. Pharmacol. 1986, 125, 273-282.
M.Y. Splinter. Rotigotine: Transdermal Dopamine Agonist Treatment of Parkinson's Disease and Restless Legs Syndrome. Ann. Pharmacother. 2007, 41, 285-295.
Jenner et al. A novel dopamine agonist for the transdermal treatment of Parkinson’s disease. Neurology. 2005, 65, S3-S5.
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
D3
D4
D1
A17
Dopamine agonist; more active enantiomer of N-0437 (Axon 1038)
Chemical name
(S)-6-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-5,6,7,8-tetrahydro-naphthalen-1-ol
Parent CAS No.
[99755-59-6]
Order
Size
Unit Price
Stock
10 mg
€105.00
In Stock | | axonmedchem |
| N 0437 hydrochloride - N 0437 | Axon 1038
CAS [102120-99-0]
MF C19H25NOS.HClMW 351.93
Purity:
99%
Soluble in DMSO
Description
Potent and selective dopamine receptor agonist as anti-Parkinson drug; its S-(-)-enantiomer (Axon 1040) is more active vs (R)-(+)-enantiomer (Axon 1039)
References
Certificates
Categories
Extra info
J van der Weide et al. Pharmacological profiles of three new, potent and selective dopamine receptor agonists: N-0434, N-0437 and N-0734. Eur. J. Pharmacol. 1986, 125, 273-282.
M.Y. Splinter. Rotigotine: Transdermal Dopamine Agonist Treatment of Parkinson's Disease and Restless Legs Syndrome. Ann. Pharmacother. 2007, 41, 285-295.
Jenner et al. A novel dopamine agonist for the transdermal treatment of Parkinson’s disease. Neurology. 2005, 65, S3-S5.
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
D3
D4
D1
A17
Dopamine agonist
Chemical name
6-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-5,6,7,8-tetrahydro-naphthalen-1-ol
Parent CAS No.
[92206-54-7]
Order
Size
Unit Price
Stock
10 mg
€135.00
In Stock | | axonmedchem |
| N 0924 hydrochloride - N 0924 | Axon 1039
CAS [125572-92-1]
MF C19H25NOS.HClMW 351.93
Purity:
100%
Optical purity:
98% ee
Soluble in water and DMSO
Description
Dopamine receptor agonist; less active enantiomer of N-0437 (Axon 1038) vs opposite (S)-(-)-enantiomer, Rotigotine (Axon 1040)
References
Certificates
Categories
Extra info
J van der Weide et al. Pharmacological profiles of three new, potent and selective dopamine receptor agonists: N-0434, N-0437 and N-0734. Eur. J. Pharmacol. 1986, 125, 273-282.
M.Y. Splinter. Rotigotine: Transdermal Dopamine Agonist Treatment of Parkinson's Disease and Restless Legs Syndrome. Ann. Pharmacother. 2007, 41, 285-295.
Jenner et al. A novel dopamine agonist for the transdermal treatment of Parkinson’s disease. Neurology. 2005, 65, S3-S5.
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
D3
D4
D1
A17
Dopamine agonist; less active enantiomer of N-0437 (Axon 1038)
Chemical name
(R)-6-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-5,6,7,8-tetrahydro-naphthalen-1-ol hydrochloride
Parent CAS No.
[112835-48-0]
Inquire | | axonmedchem |
| Aminotetraline hydrochloride, (R)-5-Methoxy-N-propyl-2- | Axon 1026
CAS [93601-85-5]
MF C14H21NO.HClMW 255.78
Purity:
98%
Optical purity:
>98% ee
No solubility data
Description
Dopamine receptor agonist
References
Certificates
Categories
Extra info
CNS
D2
D3
D4
D1
A17
Dopamine agonist
Chemical name
((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propyl-amine hydrochloride
Parent CAS No.
[101403-25-2]
Inquire | | axonmedchem |
| Aminotetraline hydrochloride, N-Methyl-N-propyl-2- | Axon 1023
CAS [134467-74-6]
MF C14H21N.HClMW 239.78
Purity:
98%
No solubility data
Description
Dopamine receptor agonist
References
Certificates
Categories
Extra info
CNS
D2
D3
D4
D1
A17
Dopamine agonist
Chemical name
Methyl-propyl-(1,2,3,4-tetrahydro-naphthalen-2-yl)-amine hydrochloride
Parent CAS No.
[67707-79-3]
Inquire | | axonmedchem |
| Aminotetraline hydrobromide, 6,7-Dihydroxy-N-methyl-N-propyl- | Axon 1021
CAS [1246094-90-5]
MF C14H21NO2.HBrMW 316.23
Purity:
98%
No solubility data
Description
Dopamine receptor agonist
References
Certificates
Categories
Extra info
CNS
D2
D3
D4
D1
A17
Dopamine agonist
Chemical name
6-(methyl(propyl)amino)-5,6,7,8-tetrahydronaphthalene-2,3-diol hydrobromide
Parent CAS No.
[1246242-30-7]
Order
Size
Unit Price
Stock
10 mg
€135.00
In Stock | | axonmedchem |
| Aminotetraline hydrochloride, 5,6-Dihydroxy-N-methyl-N-propyl- | Axon 1019
CAS [55218-13-8]
MF C14H21NO2.HClMW 271.78
Purity:
98%
No solubility data
Description
Dopamine receptor agonist
References
Certificates
Categories
Extra info
CNS
D2
D3
D4
D1
A17
Dopamine agonist
Chemical name
6-(Methyl-propyl-amino)-5,6,7,8-tetrahydro-naphthalene-1,2-diol hydrochloride
Parent CAS No.
[727966-73-6]
Inquire | | axonmedchem |
| Aminotetraline hydrochloride, 5-Methoxy-N-propyl-2- | Axon 1025
CAS [3904-24-3]
MF C14H21NO.HClMW 255.78
Purity:
95%
Soluble in water and DMSO
Description
Building Block; unknown pharmacology
KEYWORDS: 5-methoxy-N-propyl-2-aminotetraline hydrochloride | Supplier | Building block | CAS [3904-24-3] | [3899-07-8] | Serotonin | Dopamine | Non Selective | aminotetralin | DA | 5-HT | | axonmedchem |
| Hydroxy-DPAT hydrobromide, (R)-6- - DPAT, (R)-6-OH- | Axon 1010
CAS [1246094-81-4]
MF C16H25NO.HBrMW 328.29
Purity:
99%
Optical purity:
>98% ee
Soluble in water and DMSO
Description
Dopamine receptor agonist
References
Certificates
Categories
Extra info
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
D3
D4
D1
A17
Dopamine agonist
Chemical name
(R)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol hydrobromide
Parent CAS No.
[502508-84-1]
Inquire | | axonmedchem |
| Hydroxy-DPAT hydrobromide, (S)-6- - DPAT, (S)-6-OH- | Axon 1011
CAS [162992-70-3]
MF C16H25NO.HBrMW 328.29
Purity:
98%
Optical purity:
>98% ee
No solubility data
Description
Dopamine receptor agonist
References
Certificates
Categories
Extra info
CNS
D2
D3
D4
D1
A17
Dopamine agonist
Chemical name
(S)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol hydrobromide
Parent CAS No.
[162992-70-3]
Inquire | | axonmedchem |
| Hydroxy-DPAT hydrobromide, 6- - DPAT, 6-OH- | Axon 1009
CAS [76135-29-0]
MF C16H25NO.HBrMW 328.29
Purity:
99%
Soluble in water
Description
Weak dopamine receptor agonist
References
Certificates
Categories
Extra info
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
D3
D4
D1
A17
Dopamine agonist
Chemical name
6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol hydrobromide
Parent CAS No.
[75017-01-5]
Inquire | | axonmedchem |
| TL 232 hydrobromide - DPAT, 6,7-Dihydroxy- | Axon 1005
CAS [62421-17-4]
MF C16H25NO2.HBrMW 344.29
Purity:
98%
Soluble in water
Description
Dopamine receptor agonist
References
Certificates
Categories
Extra info
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
D3
D4
D1
A17
Dopamine agonist
Chemical name
6-Dipropylamino-5,6,7,8-tetrahydro-naphthalene-2,3-diol hydrobromide
Parent CAS No.
[66185-60-2]
Order
Size
Unit Price
Stock
5 mg
€95.00
In Stock | | axonmedchem |
| Phenol hydrobromide, 3-[2-(Diproplyamino)ethyl] | Axon 1002
CAS [64656-40-2]
MF C14H23NO.HBrMW 302.25
Purity:
99%
Soluble in water
Description
Dopamine receptor agonist
References
Certificates
Categories
Extra info
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
D3
D4
D1
A17
Dopamine agonist
Chemical name
3-(2-Dipropylamino-ethyl)-phenol hydrobromide
Parent CAS No.
[79412-65-0]
Order
Size
Unit Price
Stock
10 mg
€95.00
In Stock | | axonmedchem |
| Dopamine hydrobromide, N,N-Dipropyl | Axon 1001
CAS [65273-66-7]
MF C14H23NO2.HBrMW 318.25
Purity:
98%
Soluble in 0.1N HCl(aq)
Description
Dopamine receptor agonist
References
Certificates
Categories
Extra info
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
D3
D4
D1
A17
Dopamine agonist
Chemical name
4-(2-Dipropylamino-ethyl)-benzene-1,2-diol hydrobromide
Parent CAS No.
[66185-61-3]
Order
Size
Unit Price
Stock
10 mg
€95.00
In Stock | | axonmedchem |