| 产品标题 |
产品货号 |
产品规格 |
厂家 |
| N 0426 hydrochloride | Axon 1065
CAS [150542-92-0]
MF C14H17NO.HClMW 251.75
Purity:
98%
No solubility data
Description
Dopamine receptor agonist
References
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CNS
D2
D3
D4
D1
A17
Dopamine agonist
Chemical name
6-(Methyl-prop-2-ynyl-amino)-5,6,7,8-tetrahydro-naphthalen-1-ol hydrochloride
Parent CAS No.
[749180-62-9]
Inquire | | axonmedchem |
| Aminotetraline hydrochloride, Prop-2-ynyl-2- | Axon 1064
CAS [134467-59-7]
MF C13H15N.HClMW 221.73
Purity:
99%
Soluble in water and DMSO
Description
Dopamine receptor agonist
References
Certificates
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Extra info
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
D3
D4
D1
A17
Dopamine agonist
Chemical name
Prop-2-ynyl-(1,2,3,4-tetrahydro-naphthalen-2-yl)-amine
Parent CAS No.
[134467-58-6]
Inquire | | axonmedchem |
| N 0432 hydrobromide | Axon 1020
CAS [96333-05-0]
MF C14H17NO2.HBrMW 312.20
Purity:
96%
Soluble in water and DMSO
Description
Monoamine oxidase (MAO) inhibitor, dopamine agonist
References
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Extra info
Certificate of Analysis
Material Safety Data Sheet
CNS
MAO
D1
EC 1.4.3.4
MAO inhibitor; Dopamine agonist
Chemical name
6-(Methyl-prop-2-ynyl-amino)-5,6,7,8-tetrahydro-naphthalene-2,3-diol hydrobromide
Parent CAS No.
[96333-05-0]
Inquire | | axonmedchem |
| N 0430 hydrobromide | Axon 1018
CAS [96333-04-9]
MF C14H17NO2.HBrMW 312.20
Purity:
99%
Soluble in water
Description
Monoamine oxidase (MAO) inhibitor, dopamine agonist
References
Certificates
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Extra info
Certificate of Analysis
Material Safety Data Sheet
CNS
MAO
EC 1.4.3.4
MAO inhibitor; Dopamine agonist
Chemical name
6-(Methyl-prop-2-ynyl-amino)-5,6,7,8-tetrahydro-naphthalene-1,2-diol hydrobromide
Parent CAS No.
[96333-04-9]
Order
Size
Unit Price
Stock
5 mg
€115.00
In Stock | | axonmedchem |
| LY 333531 mesylate - Ruboxistaurin | Axon 1401
CAS [192050-59-2]
MF C28H28N4O3.CH4O3SMW 564.65
Purity:
99%
Soluble in DMSO
Description
Orally active protein kinase C β (PKC-β) specific inhibitor; a salt form that is five times more water-soluble than its hydrochloride salt.The hydrochloride salt of LY 333531 (Axon 2362) is available as well.
KEYWORDS: LY 333531 mesylate | supplier | PKC-β inhibitor | Ruboxistaurin | LY333531 | LY-333531 | CAS [192050-59-2] | [169939-94-0] | protein kinase | PKC-beta | orally active | ICAM-1 | MCP-1 | diabetes | glutathion | retinopathy | | axonmedchem |
| Gö 6983 - GO 6983 | Goe 6983 | Axon 2466
CAS [133053-19-7]
MF C26H26N4O3MW 442.51
Purity:
99%
Soluble in DMSO
Description
Broad spectrum PKC inhibitor lacking inhibitory effect for the PKCμ isotype (IC50 values ranging from 7-60 nM for PKCα-PKCζ , and 20000 nM for PKCμ, respectively). Gö6983 significantly enhanced ERK1/2 activity not only in IL-6-stimulated cells, but also the basal ERK1/2 activity in non-stimulated cells; yet, it has no effect on IL-6-triggered B9 cell proliferation, suggesting a crucial role for PKCμ. Useful tool for isolation, generation, derivatization and stabilization of naive human pluripotent stem cells in so called NHSM conditions developed at the Weizmann Institute of Science.
*Promotion | | axonmedchem |
| TL 102 hydrobromide - DPAT, 5,6-Dihydroxy- | Axon 1004
CAS [62421-54-9]
MF C16H25NO2.HBrMW 344.29
Purity:
98%
Soluble in water
Description
Dopamine receptor agonist
References
Certificates
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Extra info
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
D3
D4
D1
A17
Dopamine agonist
Chemical name
6-Dipropylamino-5,6,7,8-tetrahydro-naphthalene-1,2-diol hydrobromide
Parent CAS No.
[64309-39-3]
Order
Size
Unit Price
Stock
5 mg
€95.00
In Stock | | axonmedchem |
| CGP 77675 | Axon 2097
CAS [234772-64-6]
MF C26H29N5O2MW 443.54
Purity:
98%
Soluble in 0.1N HCl(aq) and DMSO
Description
Potent and selective Src family kinase (SFK) inhibitor; CGP77675 inhibited phosphorylation of peptide substrates and autophosphorylation of purified Src (IC50: 5-20 and 40 nM, respectively). The dual inhibition of Src and GSK-3 signaling by CGP 77675 and CHIR 99021 (termed alternative 2i, Axon 2130) was found to maintain mouse embryonic stem cell (mESC) self-renewal and pluripotency marker expression as efficiently as the dual inhibition of MAPK and GSK-3 by PD 0325901 and CHIR 99021 (conventional 2i, Axon 2128). This alternative 2i method provides a versatile tool not only for the maintenance of mESCs in serum-free conditions but also for the derivation of ESCs from mouse embryos.
*Promotion | | axonmedchem |
| MLR 1023 - Tolimidone | CP 26154 | Axon 1941
CAS [41964-07-2]
MF C11H10N2O2MW 202.21
Purity:
99%
Soluble in DMSO
Description
Selective allosteric activator of Lyn kinase (EC50: 63 nM); no significant activity against all other Src family kinases and a range of 47 other kinases; Next generation insulin sensitizer that does not have PPAR activity
References
Certificates
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Extra info
MS Saporito et al. MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo. J. Pharmacol. Exp. Ther. 2012, 342(1), 15-22.
AR Ochman et al. The Lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes. J. Pharmacol. Exp. Ther. 2012, 342(1), 23-32.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
Endocrinology
SRC
Lyn
EC 2.7.10.2
Selective allosteric activator of Lyn kinase
Chemical name
5-(m-tolyloxy)pyrimidin-2(1H)-one
Parent CAS No.
[41964-07-2]
Order
Size
Unit Price
Stock
10 mg
€95.00
In Stock | | axonmedchem |
| Tilfrinib | Axon 2560
CAS [1600515-49-8]
MF C17H13N3OMW 275.30
Purity:
98%
Soluble in DMSO and Ethanol
Description
Potent Brk inhibitor (breast tumor kinase; IC50 values 3.15 nM) with antiproliferative activity in various breast tumor cell lines. Brk is also known as protein tyrosine kinase 6 (PTK6).
KEYWORDS: Tilfrinib | Brk inhibitor | CAS [1600515-49-8] | Phosphorylation | Brk | Inhibitor | PTK6 | Protein Tyrosine Kinase | breast cancer | Erbb | HER2 | EGFR | STAT3 | STAT5B | antiproliferative | | axonmedchem |
| A 770041 | Axon 1698
CAS [869748-10-7]
MF C34H39N9O3MW 621.73
Purity:
99%
Soluble in DMSO
Description
Selective and orally active Src-family Lck inhibitor; A-770041 is a 147 nM inhibitor of Lck (1 mM ATP) and is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling.
Keywords: A 770041 | supplier | Lck inhibitor | A770041 | A-770041 | CAS [869748-10-7] | Non Selective (Phosphorylation Substrates) | Lck | Inhibitor | Enzymes | | axonmedchem |
| STAT5 Inhibitor 1 [285986-31-4] | Axon 2731
CAS [285986-31-4]
MF C16H11N3O3MW 293.28
Purity:
98%
Soluble in DMSO
Description
STAT5 Inhibitor 1 [285986-31-4] is a first nonpeptidic small-molecule which selectively inhibits the function of the STAT5b domain (IC50 value of 47 μM), STAT5 DNA binding in vitro, and activation of STAT5 in a cancer cell line. Also selective impairment of STAT5 phosphorylation with STAT5 Inhibitor 1 markedly reduced iTregs.
KEYWORDS: STAT5 Inhibitor 1 [285986-31-4] | supplier | STAT5 inhibitor | CAS [285986-31-4] | DNA-RNA | STAT5 | Inhibitor | Transcription Factors | CAS [1187749-60-5] | STAT5b | iTreg | | axonmedchem |
| TAK 165 - Mubritinib | Axon 2053
CAS [366017-09-6]
MF C25H23F3N4O2MW 468.47
Purity:
99%
Soluble in DMSO
Description
Highly selective, potent and irreversible human epidermal growth factor receptor 2 (HER2 aka ErbB2) antagonist (IC50: 6 nM); recommended tool compound for HER2 selective inhibition
References
Certificates
Categories
Extra info
J Nagasawa et al. Novel HER2 selective tyrosine kinase inhibitor, TAK-165, inhibits bladder, kidney and androgen-independent prostate cancer in vitro and in vivo. Int. J. Urol. 2006, 13(5), 587-592.
S Yoshida et al. Tak-165, a selective inhibitor of HER2 tyrosine kinase: 2. Mechanism of antitumor activity on HER2 signal transduction pathway. Proc. Am. Assoc. Can. Res. 2002, 43, 3898.
JC Uitdehaag et al. A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets. Br. J. Pharmacol. 2012, 166, 858–876.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
ErbB2-HER2
RTK class I; EC 2.7.10.1
ErbB2/HER2 kinase inhibitor
Chemical name
(E)-4-((4-(4-(1H-1,2,3-triazol-1-yl)butyl)phenyl1H-1,2,3-triazol-1-yl)butyl)phenoxy)methyl)-2-(4-(trifluoromethyl)styryl)oxazole
Parent CAS No.
[366017-09-6]
Order
Size
Unit Price
Stock
5 mg
€65.00
In Stock | | axonmedchem |
| CP 724714 | Axon 1537
CAS [383432-38-0]
MF C27H27N5O3MW 469.53
Purity:
98%
Soluble in DMSO
Description
A oral, selective and potent ErbB-2 (HER2) kinase inhibitor; reported to inhibit HER2-driven cell line
References
Certificates
Categories
Extra info
JP Jani et al. Discovery and Pharmacologic Characterization of CP-724,714, a Selective ErbB2 Tyrosine Kinase Inhibitor. Cancer Res. 2007, 67(20), 9887-9893.
PN Munster et al. First Study of the Safety, Tolerability, and Pharmacokinetics of CP-724,714 in Patients with Advanced Malignant Solid HER2-Expressing Tumors. Clin. Cancer Res. 2007, 13, 1238-1245.
F Guo et al. Pharmacokinetics of a HER2 tyrosine kinase inhibitor CP-724,714 in patients with advanced malignant HER2 positive solid tumors: correlations with clinical characteristics and safety. Cancer Chemother. Pharmacol. 2008, 62(1), 97-109.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
ErbB2-HER2
JAK-STAT
RTK class I; EC 2.7.10.1
ErbB-2/HER2 kinase inhibitor
Chemical name
2-Methoxy-N-((E)-3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide
Parent CAS No.
[383432-38-0]
Order
Size
Unit Price
Stock
2 mg
€80.00
In Stock | | axonmedchem |
| AZD 0530 difumarate - Saracatinib | Axon 1456
CAS [893428-72-3]
MF C27H32ClN5O5.2C4H4O4MW 774.17
Purity:
99%
Soluble in DMSO
Description
An orally bioavailable tyrosine kinase inhibitor, specifically targeting Src and Abl, those kinases often overexpressed in chronic myeloid leukema cells. Optimal water-soluble form
References
Certificates
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Extra info
H Laurent et al. N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor. J. Med. Chem. 2006, 49, 6465.
YM Chang et al. Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530. Oncogene 2008, 1–11.
PM Gwanmesia et al. The effect of the dual Src/Abl kinase inhibitor AZD0530 on Philadelphia positive leukaemia cell lines. BMC Cancer 2009, 9, 53.
TP Green et al. Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530. Molecular Oncology 2009, 3(3), 248-261.
C Dulsat et al. Saracatinib. Drugs Fut. 2009, 34(2), 106.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
SRC
ABL
EC 2.7.10.2
Inhibitor of SRC and ABL tyrosine kinases
Chemical name
(5-Chloro-benzo[1,3]dioxol-4-yl)-[7-[2-(4-methyl-piperazin-1-yl)-ethoxy]-5-(tetrahydro-pyran-4-yloxy)-quinazolin-4-yl]-amine (2E)-2-butenedioate (1:2)
Parent CAS No.
[379231-04-6]
Order
Size
Unit Price
Stock
5 mg
€105.00
In Stock | | axonmedchem |
| Dasatinib - BMS 354825 | Sprycel | Axon 1392
CAS [302962-49-8]
MF C22H26ClN7O2SMW 488.01
Purity:
99%
Soluble in DMSO
Description
Orally active dual BCR-ABL and Src family tyrosine kinases inhibitor.
KEYWORDS: Dasatinib | supplier | Bcr-Abl/Src inhibitor | BMS 354825 | Sprycel | BMS354825 | BMS-354825 | CAS [302962-49-8] | Non Selective (Phosphorylation Substrates) | BCR-ABL | SRC | Inhibitor | Enzymes | | axonmedchem |
| SU 6656 | Axon 1136
CAS [330161-87-0]
MF C19H21N3O3SMW 371.45
Purity:
99%
Soluble in DMSO
Description
A selective Src family kinase inhibitor
References
Certificates
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Extra info
RA Blake et al. SU6656, a Selective Src Family Kinase Inhibitor, Used To Probe Growth Factor Signaling. Mol. Cell Biol. 2000, 20(23), 9018–9027.
KC Cuneo et al. SRC family kinase inhibitor SU6656 enhances antiangiogenic effect of irradiation. Int. J. Radiat. Oncol. Biol. Phys. 2006, 64(4), 1197-1203.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
Stem Cell
SRC
EC 2.7.10.2
SRC kinase inhibitor
Chemical name
2-Oxo-3-[1-(4,5,6,7-tetrahydro-1H-indol-2-yl)-meth-(Z)-ylidene]-2,3-dihydro-1H-indole-5-sulfonic acid dimethylamide
Parent CAS No.
[330161-87-0]
Order
Size
Unit Price
Stock
10 mg
€120.00
In Stock | | axonmedchem |
| SKI 606 - Bosutinib | Axon 1407
CAS [380843-75-4]
MF C26H29Cl2N5O3MW 530.45
Purity:
99%
Soluble in 0.1N HCl(aq) and DMSO
Description
A tyrosine kinase inhibitor (TKI), targeting dual Bcr-Abl and Src; effective drug for chronic myelogenous leukemia (CML) or acute lymphoid leukemia (ALL)
References
Certificates
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Extra info
A Vultur et al. SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells. Mol. Cancer Ther. 2008, 7(5), 1185–1194.
W. A. Messersmith et al.Bosutinib (SKI-606), a dual Src/Abl tyrosine kinase inhibitor: Preliminary results from a phase 1 study in patients with advanced malignant solid tumors. J. Clinical Oncol. 2007, 25 (18S), 3552.
JM Goldman, JV Melo. BCR-ABL in Chronic Myelogenous Leukemia - How Does It Work? Acta Haematol. 2008, 119, 212-217.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
BCR-ABL
SRC
Oncogene Fusion Proteins
EC 2.7.10.1
Pfizer Licensed Products
Bcr-Abl and Src tyrosine kinase inhibitor
Chemical name
4-(2,4-Dichloro-5-methoxy-phenylamino)-6-methoxy-7-[3-(4-methyl-piperazin-1-yl)propoxy]quinoline-3-carbonitrile
Source information
Pfizer compound; Sold for research purposes under agreement from Pfizer Inc.
Parent CAS No.
[380843-75-4]
Order
Size
Unit Price
Stock
5 mg
€75.00
In Stock | | axonmedchem |
| FC 99 hydrochloride | Axon 2318
CAS [N.A.]
MF C15H18N2O.xHClMW 304.30
Purity:
98%
Soluble in water and DMSO
Description
Inhibitor of TLR3 expression and inflammatory responses induced by a synthetic dsRNA (poly(I:C)) and by exogenous IFN-α via IRF3. FC-99 suppressed the phosphorylation levels of ERK, JNK, and p38 in varying degrees without altering the total protein The ability of FC-99 to reverse TLR3 expression may account for its marked effect on the model of sepsis.
References
Certificates
Categories
Extra info
W. Gong et al. A novel 1,2-benzenediamine derivative FC-99 suppresses TLR3 expression and ameliorates disease symptoms in a mouse model of sepsis. Br. J. Pharmacol. 2014, 171, 4866-4878.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
Immunology
Pain & Inflammation
NF-κB
JAK-STAT
TLR3
TLR3
Inhibitor of TLR3 expression and inflammatory responses.
Chemical name
N1-(4-methoxybenzyl)-4-methylbenzene-1,2-diamine hydrochloride (1:1.7)
Parent CAS No.
[1097810-71-3]
Order
Size
Unit Price
Stock
5 mg
€95.00
In Stock | | axonmedchem |
| Wnt-C59 - C59 | Axon 2287
CAS [1243243-89-1]
MF C25H21N3OMW 379.45
Purity:
98%
Soluble in DMSO
Description
Nanomolar and orally available inhibitor of mammalian PORCN acyltransferase activity (IC50 value of 74 pM) that blocks activation of all evaluated human Wnts ( Wnt palmitoylation, Wnt interaction with the carrier protein Wntless/WLS, Wnt secretion, and Wnt activation of β-catenin reporter activity).The tumor growth inhibition of Wnt-C59 in MMTV-WNT1 transgenic mice is associated with decreased Wnt/β-catenin signaling in tumors.
References
Certificates
Categories
Extra info
K.D. Proffitt et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res. 2013, 73, 502-507.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
Stem Cell
Porcupine
Wnt-β-Catenin
EC 2.3.1
Stem Cell Differentiator
Highly potent porcupine (Porcn) inhibitor
Chemical name
2-(4-(2-methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide
Parent CAS No.
[1243243-89-1]
Order
Size
Unit Price
Stock
2 mg
€75.00
In Stock | | axonmedchem |
| NG 25 trihydrochloride | Axon 2366
CAS [2108554-00-1]
MF C29H30F3N5O2.3HClMW 646.96
Purity:
98%
Soluble in water and DMSO
Description
Type II inhibitor of TAK1 (MAP3K7) and MAP4K2 (GCK) with nanomolar potency for a wider range of kinases (IC50 values 13 nM, 22 nM, 56 nM, 75 nM, 82 nM, 102 nM, 113 nM, and 149 nM for LYN, MAP4K2, CSK, Abl, FER, p38α, SRC, and TAK1, repectively). At 0.1 µM NG25 shows strong inhibition of TAK1, Lck, MAP4K2, p38α, Abl, YES1, and OSR1. NG 25 potently inhibited the activation of IKKβ by TLR7 and TLR9 agonists and prevented the secretion of type 1 IFNs induced by these ligands in Gen2.2 cells.
KEYWORDS: NG 25 trihydrochloride | supplier | TAK1 (MAP3K7) and MAP4K2 inhibitor | NG25 | CAS [2108554-00-1] | [1315355-93-1] | MAPK | MAP3K | MAP4K | Lck | RAF | ERK | IKKβ | LYN | CSK | Abl | FER | p38α | SRC | NF-kappaB | TNF | Interferon | Immunology | PDC | Toll like | TLR | Inhibitor | Enzymes | | axonmedchem |
| Motolimod - VTX-2337 | VTX-378 | Axon 2783
CAS [926927-61-9]
MF C28H34N4O2MW 458.60
Purity:
99%
Soluble in 0.1N HCl(aq) and DMSO
Description
Motolimod is a highly potent and selective TLR8 agonist (EC50 value of 100 nM). Motolimod directly activates myeloid dendritic cells, monocytes, and NK cells, resulting in the production of high levels of mediators including: TNFα, IL-12, and IFNγ, known to orchestrate adaptive antitumor responses.
KEYWORDS: Motolimod | supplier | TLR8 agonist | VTX-2337 | VTX-378 | VTX 2337 | VTX2337 | VTX 378 | VTX378 | CAS [926927-61-9] | DNA-RNA | TLR8 | Agonist | Receptors | Antitumor | | axonmedchem |
| PF 4693627 - PF 04693627 | Axon 2020
CAS [1312815-93-2]
MF C26H29Cl2N3O3MW 502.43
Purity:
100%
Optical purity:
d.e. >98%
Soluble in DMSO
Description
Potent, selective and orally bioavailable inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) for the potential treatment of inflammation (IC50 value 3 nM and 109 nM in enzyme assay and WHB assay respectively). PF 4693627 shows excellent in vitro and in vivo properties and is selective against relevant human enzymes COX-2, TXAS, PGDS, 5-LOX, 15-LOX and 12-LOX.
References
Certificates
Categories
Extra info
G.B. Arhancet et al. Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation. Bioorg. Med. Chem. Lett. 2013, 23, 1114-1119.
D.P. Walker et al. Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: use of a conformation-based hypothesis to facilitate compound design. Bioorg. Med. Chem. Lett. 2013, 23, 1120-1126.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
Immunology
Pain & Inflammation
mPGES-1
EC 5.3.99.3
Pfizer Licensed Products
Selective and orally bioavailable inhibitor of mPGES-1
Chemical name
1-(5-chloro-6-(4-chlorophenyl)benzo[d]oxazol-2-yl)-N-((1S,3S)-3-(hydroxymethyl)cyclohexyl)piperidine-4-carboxamide
Source information
Pfizer compound; Sold for research purposes under agreement from Pfizer Inc.
Parent CAS No.
[1312815-93-2]
Order
Size
Unit Price
Stock
5 mg
€125.00
In Stock | | axonmedchem |
| CU-T12-9 | Axon 2455
CAS [1821387-73-8]
MF C17H13F3N4O2MW 362.31
Purity:
100%
Soluble in DMSO
Description
Selective TLR1/TLR2 agonist (IC50 value 54.4 nM in a competitive binding assay with Pam3CSK4) that facilitates the TLR1/2 heterodimeric complex formation, but not TLR2/6 complex formation. CU-T12-9 signals through NF-κB and invokes an elevation of the downstream effectors TNF-α, IL-10, and inducible NOS.
KEYWORDS: CU-T12-9 | Supplier | TLR1/2 agonist | CUT129 | CAS [1821387-73-8] | DNA-RNA | TLR1 | TLR2 | Modulator | Toll-like receptor | immunology | virus | NF-κB | TNF-α | IL-10 | NOS | vaccine adjuvant | antitumor | interleukin | T-cell | | axonmedchem |
| Selonsertib - GS 4997 | Axon 2956
CAS [1448428-04-3]
MF C24H24FN7OMW 445.49
Purity:
99%
Soluble in 0.1N HCl(aq) and DMSO
Recently added | | axonmedchem |
| PF 06260933 dihydrochloride | Axon 2545
CAS [N.A.]
MF C16H13ClN4.2HClMW 369.68
Purity:
99%
Soluble in water and DMSO
Description
Potent and selective MAP4K4 inhibitor (IC50 value 3.7 nM for MAP4K4 a.k.a. HGK or ZC1) with suitable PK properties in mouse to be used as a tool in an in vivo model of diabetes, vascular inflammation and atherosclerosis. Robustly prevented TNF-α-mediated endothelial permeability in vitro, similar to MAP4K4 knockdown, and without alteration of plasma lipid content.
KEYWORDS: PF 06260933 dihydrochloride | supplier | MAP4K4 inhibitor | PF06260933 | CAS [1811510-56-1] | MAPK | MAP4K | Inhibitor | HGK | ZC1 | mitogen activated | endothelial | diabetes | vascular inflammation | atherosclerosis | TNF | NF-κB | | axonmedchem |
| Selexipag - NS 304 | ACT 293987 | Uptravi | Axon 2605
CAS [475086-01-2]
MF C26H32N4O4SMW 496.62
Purity:
100%
Soluble in DMSO
Description
Orally available and long-acting prodrug of MRE 269, a potent and highly selective IP receptor agonist (Ki values 20 nM and 260 nM for inhibition of [3H]iloprost binding to human IP receptor by MRE 269 and Selexipag, respectively). Capable of ameliorating vascular endothelial dysfunction, pulmonary arterial wall hypertrophy, and right ventricular hypertrophy. Furthermore, Selexipag (NS 304) elevated right ventricular systolic pressure and improved survival in a rat model of pulmonary hypertension induced by monocrotaline (MCT).
KEYWORDS: Selexipag | supplier | IP agonist prodrug | NS 304 | ACT 293987 | NS304 | ACT293987 | CAS [475086-01-2] - [1267423-51-7] | Prostaglandins | PGI2 (IP) | Agonist | MRE269 | prodrug | prostacyclin | PGI2 | pulmonary | hypertension | vascular | endothelial | dysfunction | hypertrophy | | axonmedchem |
| NM-PP1, 1- | Axon 1892
CAS [221244-14-0]
MF C20H21N5MW 331.41
Purity:
99%
Soluble in DMSO
Description
A potent tyrosine kinase inhibitor (TKI) of multiple targets, such as v-Src (IC50: 1 μM), c-Fyn (IC50: 0.6 μM), c-Abl (IC50: 0.6 μM), CDK2 (IC50: 18 μM), and CaMK II (IC50: 22 μM). Addiitonally, 1-NM-PP1 is reported to be a potent and specific inhibitor of TrkB-F616A and TrkA-F592A signaling (IC50 values approx 3 nM).
References
Certificates
Categories
Extra info
AC Bishop et al. Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach. J. Am. Chem. Soc. 1999, 121 627-631 (1999).
X. Chen et al. A chemical-genetic approach to studying neurotrophin signaling. Neuron. 2005, 46, 13-21.
AC Bishop et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 2000, 407 395-401.
T Sugi et al. Use of the Kinase Inhibitor Analog 1NM-PP1 Reveals a Role for Toxoplasma gondii CDPK1 in the Invasion Step. Eukaryotic Cell 2010, 9(4), 667-670.
X Wang et al. TrkB signaling is required for both the induction and maintenance of tissue and nerve injury-induced persistent pain. J. Neurosci. 2009, 29(17), 5508–5515.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
SRC
ABL
EC 2.7.10.2
CDK
Trk
Potent tyrosine kinase inhibitor (TKI) of multiple targets (Src, Fyn, Abl, CDK, Trk)
Chemical name
1-tert-butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Parent CAS No.
[221244-14-0]
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Size
Unit Price
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5 mg
€95.00
In Stock | | axonmedchem |
| ASK1 Inhibitor 10 | Axon 2179
CAS [1005775-56-3]
MF C21H21N5O.2HClMW 432.35
Purity:
99%
Soluble in 0.1N HCl(aq) and DMSO
Description
Potent, selective, and orally bioavailable ASK1 inhibitor (IC50: 14 nM) with no affinity for a representative panel of kinases (IC50: >10 μM), except for ASK2 (IC50: 0.51 μM). Compound 10 shows a high ligand-lipophilicity efficiency (LLE, pIC50–logD = 4.69) value, which avoids issues of undesirable physical properties and ADME (absorption, distribution, metabolism, and elimination) profiles and interactions with other protein kinases and adverse biological activities.
References
Certificates
Categories
Extra info
Y. Terao et al. Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors. Bioorg. Med. Chem. Lett. 2012, 22, 7326-7329.
Certificate of Analysis
Material Safety Data Sheet
Apoptosis
Cell Signaling & Oncology
MAPK
EC 2.7.11.35
MAP3K
Potent, selective, and orally bioavailable ASK1 inhibitor
Chemical name
N-(6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl)-4-tert-butylbenzamide dihydrochloride
Parent CAS No.
[1005775-55-2]
Order
Size
Unit Price
Stock
10 mg
€125.00
In Stock | | axonmedchem |
| NQDI 1 | Axon 1814
CAS [175026-96-7]
MF C19H13NO4MW 319.31
Purity:
99%
Moderately soluble in DMSO
Description
Selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (KI: 500 nM)
References
Certificates
Categories
Extra info
GP Volynets et al. Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1). J. Med. Chem. 2011, 54(8), 2680-2686.
Certificate of Analysis
Material Safety Data Sheet
Apoptosis
Cell Signaling & Oncology
MAPK
EC 2.7.11.35
MAP3K
Inhibitor of apoptosis signal-regulating kinase 1 (ASK1)
Chemical name
ethyl 2,7-dioxo-3,7-dihydro-2H-naphtho[1,2,3-de]quinoline-1-carboxylate
Parent CAS No.
[175026-96-7]
Order
Size
Unit Price
Stock
10 mg
€115.00
In Stock | | axonmedchem |
| Alprostadil - Prostaglandin E1 | PGE1 | Axon 2062
CAS [745-65-3]
MF C20H34O5MW 354.48
Purity:
100%
Soluble in DMSO
Description
A prostaglandin drug used in the treatment of erectile dysfunction with vasodilatory properties; Binds EP receptors with Ki values of 36, 10, 1.1 and 2.1 nM for EP1, EP2, EP3 and EP4 respectively and 33 nM for IP receptor
References
Certificates
Categories
Extra info
H Padma-Nathan et al. Treatment of men with erectile dysfunction with transurethral alprostadil. N. Engl. J. Med. 1997, 336(1) 1-7.
OI Linet and FG Ogrinc. Efficacy and safety of intracavernosal alprostadil in men with erectile dysfunction. N. Engl. J. Med. 1996, 334(14), 873-877.
Certificate of Analysis
Material Safety Data Sheet
Cardiovascular
Cell Signaling & Oncology
Immunology
Pain & Inflammation
PGE2 (EP1)
PGE2 (EP2)
PGE2 (EP3)
A14
Pfizer Licensed Products
Prostaglandin EP (1-4) receptor antagonist
Chemical name
7-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)heptanoic acid
Source information
Pfizer compound; Sold for research purposes under agreement from Pfizer Inc.
Parent CAS No.
[745-65-3]
Order
Size
Unit Price
Stock
10 mg
€105.00
In Stock | | axonmedchem |
| AZD 1981 | Axon 2145
CAS [802904-66-1]
MF C19H17ClN2O3SMW 388.87
Purity:
99%
Soluble in 0.1N NaOH(aq) and DMSO
Description
Potent, orally bio-available and selective CRTh2 (also known as DP2) antagonist; AZD1981 inhibited PGD2 binding to human CRTh2 with an IC50 of 4 nM
References
Certificates
Categories
Extra info
JA Schmidt et al. Biochemical and pharmacological characterization of AZD1981, an orally available selective DP2 antagonist in clinical development for asthma. Br. J. Pharmacol. 2013, 168(7), 1626-1638.
N Snell et al. Efficacy and safety of AZD1981, a CRTH2 receptor antagonist, in patients with moderate to severe COPD. Respir Med. 2013 Jul 1. pii: S0954-6111(13)00218-7.
T Luker et al. Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981. Bioorg. Med. Chem. Lett. 2011, 21(21), 6288-6292.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
Pain & Inflammation
CRTH2
A14
Selective CRTH2 (aka DP2) antagonist
Chemical name
2-(4-acetamido-3-(4-chlorophenylthio)-2-methyl-1H-indol-1-yl)acetic acid
Parent CAS No.
[802904-66-1]
Order
Size
Unit Price
Stock
5 mg
€105.00
In Stock | | axonmedchem |
| PF 04418948 | Axon 2024
CAS [1078166-57-0]
MF C23H20FNO5MW 409.41
Purity:
99%
Soluble in 0.1N NaOH(aq) and DMSO
Description
An orally active, potent and selective prostaglandin EP2 receptor antagonist
References
Certificates
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Extra info
KJ af Forselles et al. In vitro and in vivo characterization of PF-04418948, a novel, potent and selective prostaglandin EP2 receptor antagonist. Br. J. Pharmacol. 2011, 164(7), 1847-1856.
MA Birrell et al. Selectivity profiling of the novel EP2 receptor antagonist, PF-04418948, in functional bioassay systems: atypical affinity at the guinea pig EP2 receptor. Br. J. Pharmacol. 2013, 168(1), 129-138.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
Immunology
Pain & Inflammation
PGE2 (EP2)
A14
Pfizer Licensed Products
Prostaglandin EP2 receptor antagonist
Chemical name
1-(4-fluorobenzoyl)-3-((6-methoxynaphthalen-2-yloxy)methyl)azetidine-3-carboxylic acid
Source information
Pfizer compound; Sold for research purposes under agreement from Pfizer Inc.
Parent CAS No.
[1078166-57-0]
Order
Size
Unit Price
Stock
5 mg
€95.00
In Stock | | axonmedchem |
| ONO 8711 dicyclohexyl amine salt | Axon 1512
CAS [N.A.]
MF C22H30ClNO4S.C12H23NMW 621.31
Purity:
98%
Soluble in DMSO
Description
A selective prostaglandin E (PGE) receptor EP1 antagonist with chemopreventive effects
References
Certificates
Categories
Extra info
T Kawamori et al. Chemopreventive effects of ONO-8711, a selective prostaglandin E receptor EP1 antagonist, on breast cancer development. Carcinogenesis. 2001, 22(12), 2001-2004.
H Makita et al. A prostaglandin E2 receptor subtype EP1-selective antagonist, ONO-8711, suppresses 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis. Carcinogenesis 2007, 28(3), 677-684.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
Immunology
Pain & Inflammation
PGE2 (EP1)
A14
PGE1 receptor EP1 antagonist
Chemical name
(Z)-6-{(2R,3S)-3-[(4-Chloro-2-methyl-benzenesulfonylamino)-methyl]-bicyclo[2.2.2]oct-2-yl}-hex-5-enoic acid dicyclohexyl-amine salt
Parent CAS No.
[216158-34-8]
Order
Size
Unit Price
Stock
5 mg
€120.00
In Stock | | axonmedchem |
| S 5751 | Axon 1605
CAS [209268-36-0]
MF C25H31NO4SMW 441.58
Purity:
99%
Optical purity:
Optically pure
Soluble in 0.1N NaOH(aq) and DMSO
Description
Potent, selective and orally active prostaglandin D2 (PGD2) receptor DP antagonist, Ki values to be 1.6 and 24.2 nM for human DP and TP receptors
References
Certificates
Categories
Extra info
A Arimura et al. Prevention of Allergic Inflammation by a Novel Prostaglandin Receptor Antagonist, S-5751. J. Pharmacol. Exp. Ther. 2001, 298(2), 411-419.
S Mitsumori et al. Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D2 receptor antagonists... J. Med. Chem. 2003, 46(12), 2446-55.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
Immunology
Pain & Inflammation
PGD2 (DP1)
A14
PGD2 receptor DP1 antagonist
Chemical name
(Z)-7-((1R,2R,3S,5S)-2-(5-hydroxybenzo[b]thiophene-3-carboxamido)-6,6-dimethylbicyclo[3.1.1]heptan-3-yl)hept-5-enoic acid
Parent CAS No.
[209268-36-0]
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Size
Unit Price
Stock
2 mg
€115.00
In Stock | | axonmedchem |
| OC 000459 | Axon 1913
CAS [851723-84-7]
MF C21H17FN2O2MW 348.37
Purity:
98%
Soluble in 0.1N NaOH(aq) and DMSO
Description
Potent, oral and selective CRTH2 (also known as DP2) antagonist; under clinic development
References
Certificates
Categories
Extra info
R Pettipher et al. Pharmacologic Profile of OC000459, a Potent, Selective, and Orally Active D Prostanoid Receptor 2 Antagonist That Inhibits Mast Cell-Dependent Activation of T Helper 2 (...). J. Pharmacol. Exp. Ther. 2012, 340(2), 473-482.
F Horak et al. The CRTH2 antagonist OC000459 reduces nasal and ocular symptoms in allergic subjects exposed to grass pollen, a randomised, placebo-controlled, double-blind trial. Allergy 2012
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
Pain & Inflammation
CRTH2
A14
Selective DP2 (CRTH2) antagonist
Chemical name
2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-indol-1-yl)acetic acid
Parent CAS No.
[851723-84-7]
Order
Size
Unit Price
Stock
5 mg
€90.00
In Stock | | axonmedchem |
| MK 0524 sodium salt - Laropiprant | Axon 1480
CAS [572874-50-1]
MF C21H18ClFNNaO4SMW 457.88
Purity:
99%
Optical purity:
Optically pure
Soluble in water and Ethanol
Description
Potent and selective prostaglandin D2 (PGD2) receptor 1 (DP1) antagonist; Ki values to be 0.57 nM and 750 nM for DP1 and DP2 receptors respectively
References
Certificates
Categories
Extra info
K Chang et al. Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. PNAS 2006, 103(17), 6682-6687.
CF Sturino et al. Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524). J. Med. Chem. 2007, 50(4), 794-806.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
Immunology
Pain & Inflammation
PGD2 (DP1)
A14
PGD2 receptor DP1 antagonist
Chemical name
[(R)-4-(4-chloro-benzyl)-7-fluoro-5-methanesulfonyl-1,2,3,4-tetrahydro-cyclopenta[b]indol-3-yl]-acetate sodium salt
Parent CAS No.
[571170-77-9]
Order
Size
Unit Price
Stock
5 mg
€125.00
In Stock | | axonmedchem |
| Flumethasone | Axon 1169
CAS [2135-17-3]
MF C22H28F2O5MW 410.45
Purity:
99%
Optical purity:
Optically pure
Soluble in DMSO
Description
Selective and potent topical glucocorticoid receptor agonist (IC50 value 0.26 nM for human GR). For the treatment of various allergic, inflammatory, and autoimmune disorders.
References
Certificates
Categories
Extra info
C. Grossmann et al. Transactivation via the human glucocorticoid and mineralocorticoid receptor by therapeutically used steroids in CV-1 cells: a comparison of their glucocorticoid and mineralocorticoid properties. Eur. J. Endocrinol. 2004, 151, 397–406.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
Immunology
Pain & Inflammation
Endocrinology
NR3C
Glucocorticoid (GR)
Selective and potent glucocorticoid receptor agonist
Chemical name
(6S,9R,10S,11S,13S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-17-(2-hydroxy-acetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one
Parent CAS No.
[2135-17-3]
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Unit Price
Stock
25 mg
€60.00
In Stock | | axonmedchem |
| Flumethasone pivalate - Locorten | NSC 107680 | Axon 2247
CAS [2002-29-1]
MF C27H36F2O6MW 494.57
Purity:
99%
Soluble in DMSO and Ethanol
Description
Topical glucocorticoid receptor agonist. Flumethasone pivalate is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties.
References
Certificates
Categories
Extra info
M. Baeck et al. Corticosteroid cross-reactivity: clinical and molecular modelling tools. Allergy 2011, 66, 1367–1374.
N. Bodor et al. Structure-activity relationships in the antiinflammatory steroids: a pattern-recognition approach. J. Med. Chem. 1983, 26, 318-328.
S. Höller et al. Effect of selected fluorinated drugs in a "ringing" gel on rheological behaviour and skin permeation. Eur. J. Pharm. Biopharm. 2007, 66, 120-126.
Flumethasone pivalate (Locorten) and other topical steroids. Med. Lett. Drugs Ther. 1971, 13, 33-35.
Certificate of Analysis
Material Safety Data Sheet
Cardiovascular
Miscellaneous
Pain & Inflammation
NR3C
Glucocorticoid (GR)
Topical glucocorticoid receptor agonist
Chemical name
2-((6S,9R,10S,11S,13S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl pivalate
Parent CAS No.
[2002-29-1]
Order
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Unit Price
Stock
10 mg
€60.00
In Stock | | axonmedchem |
| ZK 216348, (+)- | Axon 2239
CAS [669073-68-1]
MF C24H23F3N2O5MW 476.45
Purity:
99%
Optical purity:
Optically pure
Soluble in DMSO
Description
Selective nonsteroidal glucocorticoid receptor (GR) agonist for the treatment of experimental colitis with IC50 values of 20, 20, and 80 nM for GR, Progesterone (PR) and Mineralocorticoid (MR) receptors respectively. (+)-ZK 216348 shows antiinflammatory activity comparable to prednisolone for both systemic and topical application, with a significant dissociation between transrepression and transactivation of antiinflammatory effects both in vitro and in vivo.(+)-ZK 216348 showed no negative effects on intestinal epithelial migration or proliferation. (-)-ZK 216348 is completely inactive (IC50 >1000 nM for GR, PR, and MR.
References
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Extra info
S. Jaroch te al. Discovery of quinolines as selective glucocorticoid receptor agonists. Bioorg. Med. Chem. Lett. 2010, 20, 5835-5838.
H .Schäcke et al. Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects. Proc. Natl. Acad. Sci. USA. 2004, 101, 227-232.
K.C. Reuter et al. Selective glucocorticoid receptor agonists for the treatment of inflammatory bowel disease: studies in mice with acute trinitrobenzene sulfonic acid colitis. J. Pharmacol. Exp. Ther. 2012, 341, 68-80.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
Immunology
Pain & Inflammation
Endocrinology
NR3C
Glucocorticoid (GR)
Selective nonsteroidal glucocorticoid receptor (GR) agonist
Chemical name
(+)-4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-N-(4-methyl-1-oxo-1H-benzo[d][1,2]oxazin-6-yl)-2-(trifluoromethyl)pentanamide
Parent CAS No.
[669073-68-1]
Order
Size
Unit Price
Stock
2 mg
€125.00
In Stock | | axonmedchem |
| Methylprednisolone | Axon 2066
CAS [83-43-2]
MF C22H30O5MW 374.47
Purity:
99%
Soluble in DMSO and Ethanol
Description
A synthetic glucocorticoid or corticosteroid drug; anti-inflammatory
References
Certificates
Categories
Extra info
D. Czock et al. Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids. Clin. Pharmacokinet. 2005, 44, 61-98.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
Immunology
Pain & Inflammation
Endocrinology
NR3C
Glucocorticoid (GR)
Pfizer Licensed Products
Synthetic glucocorticoid drug; anti-inflammatory
Chemical name
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
Source information
Pfizer compound; Sold for research purposes under agreement from Pfizer Inc.
Parent CAS No.
[83-43-2]
Order
Size
Unit Price
Stock
50 mg
€65.00
In Stock | | axonmedchem |
| Flunisolide - AeroBid | Nasalide | Nasarel | Axon 1429
CAS [3385-03-3]
MF C24H31FO6MW 434.50
Purity:
99%
Soluble in DMSO
Description
A corticosteroid used for the treatment of allergic rhinitis.
KEYWORDS: Flunisolide | supplier | 3385-03-3 | Corticosteroid | AeroBid | Nasalide | Nasarel | Glucocorticoid (GR) | Nuclear receptor | corticoid | allergy | rhinitis | | axonmedchem |
| RU 42698 - Mifepristone, Hydroxy- | Axon 1558
CAS [105012-15-5]
MF C29H35NO3MW 445.59
Purity:
99%
Optical purity:
Optically pure
Soluble in DMSO
Description
Metabolite of Mifepristone (Axon 1502); a useful tool in researching mifepristone action
References
Certificates
Categories
Extra info
O Heikinheimo et al. Metabolism and serum binding of Ru 486 in women after various single doses. Human Reproduction, 1987, 2(5), 379-385.
YE Shi et al. Pharmacokinetic study of RU 486 and its metabolites after oral administration of single doses to pregnant and non-pregnant women. Contraception 1993, 48(2), 133-149.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
Endocrinology
NR3C
Glucocorticoid (GR)
Metabolite of Mifepristone (Axon 1502)
Chemical name
Estra-4,9-dien-3-one, 11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(3-hydroxy-1-propynyl)-, (11β,17β)-
Parent CAS No.
[105012-15-5]
Order
Size
Unit Price
Stock
2 mg
€125.00
In Stock | | axonmedchem |
| Fluticasone propionate | Axon 1404
CAS [80474-14-2]
MF C25H31F3O5SMW 500.57
Purity:
99%
Soluble in DMSO
Description
High affinity, selective glucocorticoid receptor agonist; corticosteroid derived from fluticasone used to treat asthma and allergic rhinitis.
KEYWORDS: Fluticasone propionate | supplier | Glucocorticoid agonist | CAS [80474-14-2] | Glucocorticoid | Glucocorticoid (GR) | Agonist | Receptors | | axonmedchem |
| Trifluoro-3-(5-fluoro-2-methoxy-phenyl)-3-methyl-butan-2-one, 1,1,1- | Axon 1176
CAS [N.A.]
MF C12H12F4O2MW 264.22
Purity:
98%
No solubility data
Description
Glucocorticoid receptor modulator
References
Certificates
Categories
Extra info
Immunology
Miscellaneous
Pain & Inflammation
Endocrinology
Non Selective
Building block for Glucocorticoid ligand
Chemical name
1,1,1-trifluoro-3-(5-fluoro-2-methoxyphenyl)-3-methylbutan-2-one
Parent CAS No.
[N.A.]
Inquire | | axonmedchem |
| Ciclesonide | Axon 1426
CAS [126544-47-6]
MF C32H44O7MW 540.69
Purity:
99%
Soluble in DMSO
Description
A glucocorticoid used to treat obstructive airway disease
References
Certificates
Categories
Extra info
E Mutch et al. The role of esterases in the metabolism of ciclesonide to desisobutyryl-ciclesonide in human tissue. Biochem Pharmacol. 2007, 73(10), 1657–1664.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
Immunology
Pain & Inflammation
Endocrinology
NR3C
Glucocorticoid (GR)
Glucocorticoid
Chemical name
Isobutyric acid 2-((4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-8-cyclohexyl-5-hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-7,9-dioxa-pentaleno[2,1-a]phenanthren-6b-yl)-2-oxo-ethyl ester
Parent CAS No.
[126544-47-6]
Order
Size
Unit Price
Stock
10 mg
€65.00
In Stock | | axonmedchem |
| Levonorgestrel | Axon 2065
CAS [797-63-7]
MF C21H28O2MW 312.45
Purity:
99%
Soluble in DMSO
Description
A second generation synthetic progestogen used as an active ingredient in some hormonal contraceptives; binds to the progesterone receptor (PR) as an agonist; a synthetic progesterone steroid that displays potent progestional and androgenic effects but it lacks estrogen-like activity
References
Certificates
Categories
Extra info
H von Hertzen et al. Low dose mifepristone and two regimens of levonorgestrel for emergency contraception: a WHO multicentre randomised trial. The Lancet, 2002, 360(9348), 1803-1810.
AE Lemus et al. Mechanism of action of levonorgestrel: In vitro metabolism and specific interactions with steroid receptors in target organs. J. Steroid Biochem. Mol. Biol. 1992, 41(3), 881-890.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
Endocrinology
NR3C
Progesterone (PR)
Pfizer Licensed Products
Progesterone receptor (PR) agonist
Chemical name
(8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
Source information
Pfizer compound; Sold for research purposes under agreement from Pfizer Inc.
Parent CAS No.
[797-63-7]
Order
Size
Unit Price
Stock
25 mg
€50.00
In Stock | | axonmedchem |
| Asoprisnil - J 867 | Axon 1675
CAS [199396-76-4]
MF C28H35NO4MW 449.58
Purity:
98%
Soluble in DMSO
Description
A selective progesterone receptor (PR) modulator, tested for treatment of progesterone sensitive myomata
References
Certificates
Categories
Extra info
D DeManno et al. Asoprisnil (J867): a selective progesterone receptor modulator for gynecological therapy. Steroids 2003, 68 (10-13), 1019–1032.
G Schubert et al. Discovery, chemistry, and reproductive pharmacology of asoprisnil and related 11beta-benzaldoxime substituted selective progesterone receptor modulators (SPRMs). Semin Reprod Med. 2005, 23(1), 58-73.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
Endocrinology
NR3C
Progesterone (PR)
Progesterone receptor (PR) modulator
Chemical name
4-((8S,11R,13S,14S,17S)-17-Methoxy-17-(methoxymethyl)-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-11-yl)benzaldehyde oxime
Parent CAS No.
[199396-76-4 ]
Order
Size
Unit Price
Stock
5 mg
€120.00
In Stock | | axonmedchem |
| Axon 1171 - Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxo-, (6a,11b,16a,17a)- | Axon 1171
CAS [80473-92-3]
MF C21H26F2O4SMW 412.49
Purity:
98%
No solubility data
Description
Steroid derivative; precursor for e.g. fluticasone
References
Certificates
Categories
Extra info
Certificate of Analysis
Material Safety Data Sheet
Endocrinology
Non Selective
Building Block; unknown pharmacology
Chemical name
(6S,9R,10S,11S,13S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioic acid
Parent CAS No.
[80473-92-3]
Order
Size
Unit Price
Stock
50 mg
€165.00
In Stock | | axonmedchem |
| Mifepristone - RU 38486 | RU 486 | Axon 1502
CAS [84371-65-3]
MF C29H35NO2MW 429.59
Purity:
99%
Soluble in DMSO
Description
A progesterone receptor (PR) antagonist, used as an abortifacient in the first two months of pregnancy, and in smaller doses as an emergency contraceptive
References
Certificates
Categories
Extra info
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
Endocrinology
NR3C
Progesterone (PR)
Progesterone receptor (PR) antagonist
Chemical name
11β-[p-(Dimethylamino)fenyl]-17β-hydroxy- 17-(1-propynyl)estra-4,9-dien-3-on
Parent CAS No.
[84371-65-3]
Order
Size
Unit Price
Stock
10 mg
€45.00
In Stock | | axonmedchem |