Benchtop 软骨质量wu损评估仪系统,台式测量关节软骨系统
型号:Benchtop ?
价格:请致电：010-67529703
品牌:bio momentum
Benchtop ?是医疗器械?的实验室版本，可对关节软骨进行j确的wu损评估。 它计算了一个定量参数，反映了每个测量部位关节软骨的生化成分和承重te性。
为有兴趣仅在离体关节软骨上使用该工具的研究人员开发。 提供非wu菌一次性吸头，可以配备配备高分辨率相机和相机定位软件的测试室，用于绘制大型骨软骨样本。
软骨研究
Benchtop ?在软骨修复领域提供了大量研究机会：
- 了解软骨疾病，包括软骨退化的潜在原因
- 开发新的治疗产品和软骨修复技术
- 构建可靠的骨关节炎动物模型
- 创建不同种类的引用映射
点和特点
工作原理
台式?测量关节软骨的压缩诱导的流动电位。在温和压缩软骨表面期间使用压头测量这些电信号（参见下图）：
te的压头设计包括覆盖有37个微电ji阵列的球形表面。
该装置计算软骨机电活动的定量参数（QP），其对应于当其流动电位的总和达到100mV时与软骨接触的微电ji的数量。 高QP表示弱机电te性，反之亦然。 QP是可再现的，并且与施加的力和压头取向wu关。
应用文献：
Development of an Electromechanical Grade to Assess Human Knee Articular Cartilage QualitySim S, Chevrier A, Garon M, Quenneville E, Lavigne P and Buschmann MDAnn Biomed Eng. doi: 10.1007/s10439-017-1879-4. (2017)
Quantitative assessments of articular cartilage function are needed to aid clinical decision making. Our objectives were to develop a new electromechanical grade to assess quantitatively cartilage quality and test its reliability. Electromechanical properties were measured using a hand-held electromechanical probe on 200 human articular surfaces from cadaveric donors and osteoarthritic...Read More
Electromechanical properties of human osteoarthritic and asymptomatic articular cartilage are sensitive and early detectors of degenerationHadjab I, Sim S, Karhula S.S, Kauppinen S. Garon M, Quenneville E, Lavigne P, Lehenkari P.P and Buschmann MDOsteoarthritis Cartilage. doi: http://doi.org/10.1016/j.joca.2017.12.002. (2017)
Objective: To evaluate cross-correlations of ex vivo electromechanical properties with cartilage and subchondral bone plate thickness, as well as their sensitivity and specificity regarding early cartilage degeneration in human tibial plateau.
Method: Six pairs of tibial plateaus were assessed ex vivo using an electromechanical probe ()...Read More
Electromechanical probe and automated indentation maps are sensitive techniques in assessing early degenerated human articular cartilageSim S, Chevrier A, Garon M, Quenneville E, Lavigne P, Yaroshinsky A and Buschmann M DJournal of Orthopaedic Research, 35(4), 858-867.
Recent advances in the development of new drugs to halt or even reverse the progression of Osteoarthritis at an early-stage requires new tools to detect early degeneration of articular cartilage. We investigated the ability of an electromechanical probe and an automated indentation technique to characterize entire human articular surfaces for rapid non-destructive discrimination between early degenerated...Read More
Combined Mechanical Characterizations Increases Sensitivity in the Assessment of Human Cartilage DegenerationSim S, Hadjab I, Chevrolat L-A, Masse M, Tong AL, Lavigne P, Garon M, Quenneville E and Buschmann MDAccepted for a podium presentation at ORS 2017
Introduction: We published a recent study showing superior sensitivity of electromechanical and indentation (instantaneous response) assessments versus well-established techniques, including histological Mankin s, to characterize cartilage degeneration. This study aims to determine whether the combination of instantaneous, relaxation and equilibrium mechanical properties and friction...Read More
Non-destructive electromechanical assessment () of human articular cartilage correlates with histological ss and biomechanical propertiesSim S, Chevrier A, Garon M, Quenneville E, Yaroshinsky A, Hoemann CD and Buschmann MDOsteoarthritis Cartilage, 22(11) 1926-35. (2014)
OBJECTIVE:The hand-held ? device is used to map electromechanical properties of articular cartilage. The purpose of the study was to evaluate correlation of electromechanical properties with histological, biochemical and biomechanical...Read More
Freeze-Dried Chitosan-PRP Injectable Surgical Implants for Meniscus Repair: Pilot Feasibility Studies in Ovine ModelsGhazi Zadeh L, Chevrier A, Hurrtig MB, Farr J, Rodeo S, Hoemann CD and Buschmann MDRegen Med Ther, 1(1) 16-29. (2017)
Clinical management of meniscus tears often involves partial meniscectomy, which can lead to Osteoarthritis (OA). Meniscus repair augmentation strategies are being developed to compensate for the tissue’s limited healing response. The purpose of the study was to assess the feasibility of using implants composed of freeze-dried Chitosan (CS) solubilized in Platelet-Rich Plasma (PRP) to improve...Read More
Comparison Between In Vitro and Simulated Arthroscopy Electromechanical Measurements of Human Articular Surfaces Using the Sim S, Becher C, Garon M, Quenneville E, Hurschler C and Buschmann MDInternational Cartilage Repair Society 2016 in Sorrento, Italy. Poster 132
Purpose: The output of the was originally streaming potentials integral (SPI) parameter (Abedian-2013). Since then, the output has changed to a quantitative parameter (QP) (Sim-2014). The purpose of this study was to reanalyzed old data to investigate whether QP values are reliable for assessing articular cartilage in a clinical context.
Materials & Methods:...Read More
Electromechanical probe and automated indentation maps are sensitive techniques in assessing early degenerated human articular cartilageSim S, Chevrier A, Garon M, Quenneville E, Lavigne P, Yaroshinsky A, Hoemann CD and Buschmann MDJ Orthop Res, 35(4) 858-867. (2017) Epub 2016 Jun 22
Recent advances in the development of new drugs to halt or even reverse the progression of Osteoarthritis at an early-stage requires new tools to detect early degeneration of articular cartilage. We investigated the ability of an electromechanical...Read More
Assessment of Human Articular Cartilage Issued from Asymptomatic & TKR DonorsHadjab I, Sim S, Quenneville E, Garon M and Buschmann MDBiomedical Engineering Society 2015 in Tampa, Floride
Introduction: Cartilage degeneration is a progressive process and currently, only end-stage surgical treatments such as total knee replacement (TKR) lead to an improved condition. To prevent or delay this surgery, several less invasive alternatives could be considered, such as pharmacological treatments, scaffolds and partial replacements1. However, current diagnostic techniques are limited...Read More
Streaming Potential-Based Arthroscopic Device Can Detect Changes Immediately Following Localized Impact in an Equine Impact Model of OsteoarthritisChangoor A, Quenneville E, Garon M, Hurtig MB and Buschmann MDOsteoarthritis and Cartilage, Vol. 17, Supplement 1, S53, World Congress on Osteoarthritis, September 2009, Montreal, Quebec, Canada. (2009)
Early Post-traumatic Osteoarthritis (PTOA) can be asymptomatic but represents a possible window of opportunity for therapeutic intervention before disease progression. Impact models are ideal for studying these strategies because the location and severity of impact can be controlled. Streaming potentials generated during cartilage compression are a sensitive measure of degeneration, which may be valuable...Read More
Correlation of Non-destructive Electromechanical Probe () Assessment with Histological Ss and Mechanical Properties in Human Tibial PlateauSim S, Chevrier A, Garon M, Quenneville E and Buschmann MDOrthopeadic Research Society Annual Meeting in Las Vegas, 2015, Poster 1228
The purpose of the study was to investigate if electromechanical properties of human tibial plateau correlate strongly with histological ss and with biomechanical properties as in human distal femurs (Sim et al., 2014). Six pairs of tibial plateau from human donors (5 males and 1 female, average age 48 years) were provided by RTI Surgical (FL, USA). Ex vivo electromechanical properties were mapped...Read More
Evaluation of Entire Ovine Cartilage Repair Articular Surfaces: Mechanical and Electromechanical AssessmentSim S, Hadjab I, Garon M, Quenneville E, Hurtig MB, Buschmann MD and Hoemann CDTransactions of International Cartilage Repair Society (ICRS), Chicago, 2015, 7-11 May 2015, e-Poster: P87
Purpose: To demonstrate the ability of non-destructive electromechanical device and automated indentation technique in assessing the quality of cartilage in a sheep model of cartilage repair.
Methods: Ex vivo electromechanical and mechanical mappings of articular surfaces (~40 positions/map) were performed over distal condyles from 5 treated sheep (8 – 9 y-o,...Read More
Age-dependence of the Pattern of Cartilage Electromechanical Properties in the Ovine Stifle JointSim S, Picard G, Quenneville E, Garon M and Buschmann MDTransactions of the 59th Annual Meeting of the Orthopaedic Research Society, San Antonio, TX, USA, 2013.
Introduction: The biochemical composition and mechanical/electromechanical properties of articular cartilage evolve during growth. The objective of this study was to examine the age-dependence in the distribution pattern of electromechanical properties of ovine articular cartilage. To achieve this goal, we used a hand-held medical device (), designed to be used during arthroscopy,...Read More
Electromechanical Assessment of Human Knee Articular Cartilage with Compression-Induced Streaming PotentialsBecher C, Ricklefs M, Willbold E, Hurschler C, and Abedian RCartilage, 7(1) 62-69. (2016)
To assess the electromechanical properties of human knee articular cartilage with compression-induced streaming potentials for reliability among users and correlation with macroscopic and histological evaluation tools and sulfated glycosaminoglycan (sGAG) content.Streaming potentials are induced in cartilage in response to loading when mobile positive ions in the interstitial fluid temporarily move...Read More
Characterization of tissue engineered cartilage products - Recent developments in advanced therapyMaciulaitis J, Rekstyte S, Usas A, Jankauskaite V, Gudas R, Malinauskas M and Maciulaitis RPharmacological Research 113 (2016) 823–832
Legislative requirements for the quality of pharmacological agents underwent certain evolution when new type of therapies emerged. This relates to cell based medicines, such as tissue engineered cartilage products (TECP) which are increasingly developed as new modalities for widely prevalent orthopaedic disorders. Although quality measures for TECP are subject to the same general regulatory quality...Read More
Impact of storage conditions on electromechanical, histological and histochemical properties of osteochondral allograftsMickevicius T, Pockevicius A, Kucinskas A, Gudas R, Maciulaitis J, Noreikaite A and Usas ABMC Musculoletal Disorders, 16(1), 314. (2015)
Background: Osteochondral allograft transplantation has a good clinical outcome, however, there is still debate on optimization of allograft storage protocol. Storage temperature and nutrient medium composition are the most critical factors for sustained biological activity of grafts before implantation. In this study, we performed a time-dependent in vitro experiment to investigate the effect...Read More
Assessment of allograft performance in vivo using electromechanical properties of articular cartilageUsas A, Mickevicius T, Pockevicius A, Kucinskas A, Maciulaitis J and Gudas RInternational Cartilage Repair Society (ICRS), Sorrento, 2016, Poster P211
Purpose: Clinical outcome of osteochondral allograft transplantation (OAT) depends on allograft quality. There is a lack of rapid and reliable non-destructive methods for intraoperative evaluation of repaired cartilage. Measurement of cartilage electromechanical properties offers novel possibilities to monitor cartilage healing after OAT. The purpose of our study was to evaluate in vivo performance...Read More
Decrease of the electrical potentials measured on the surface of the knee and produced by cartilage compression during successive loading cyclesZhu L, Garon M, Quenneville E, Buschmann MD and Savard PJournal of Biomechanics, 49(14), 3587-3591. (2016)
Electroarthrography (EAG) is a new technique formeasuring electrical potentials appearing on the knee surface during loadingthat reflects cartilage quality and joint contact force. Our objective was toinvestigate the evolution of EAG signals during successive loading cycles. Thestudy was conducted on 20 standing subjects who shifted their body weight toachieve knee loading. Their EAG signals were recorded...Read More
Mechanical loading of knee articular cartilage induced by muscle contraction can be assessed by measuring electrical potentials at the surface of the kneeZhu L, Buschmann MD and Savard PJournal of biomechanics, 49(3), 338-343. (2016)
Electroarthrography (EAG) consists of recording electrical potentials on the knee surface that originate from streaming potentials within articular cartilage while the joint is undergoing compressive loading. The aim was to investigate how the contraction of specific leg muscles affects the contact force of the knee joint and, in turn, the EAG values.
For six normal subjects, voluntary isometric...Read More
For six normal subjects, voluntary isometric...Read More
Electroarthrography Provides a Non-invasive Streaming Potential-Based Method for Detecting Cartilage Degeneration in an Equine Model TransactionsChangoor A, Hoba MA, Quenneville E, Garon M, Gordon K, Buschmann MD, Savard P and Hurtig MBThe 59th Annual Meeting of the Orthopaedic Research Society, San Antonio, TX, USA, 1974. (2013)
Degenerative joint diseases, like osteoarthritis, are characterized by progressive cartilage degeneration, which can lead to pain and loss of mobility. Low-grade cartilage deterioration occurs early in disease progression and may be treatable. However, current clinical assessment methodologies, including physical exam, synovial fluid analysis and imaging, may not be sensitive enough to detect early...Read More
Streaming Potential-Based Arthroscopic Device Discerns Topographical Differences In Cartilage Covered And Uncovered By Meniscus In Ovine Stifle JointsChangoor A, Quenneville E, Garon M, Cloutier L, Hurtig MB and Buschmann MDTransactions of the 53th Annual Meeting of the Orthopaedic Research Society, San Diego, CA, USA, 32:631. (2007)
Animal models of osteoarthritis have been used for understanding diseaseprogression and are essential for assessing potential new therapies. Ovine models, such as the lateral meniscectomy model, are of interest because meniscectomy models often follow a disease progression similar to that in humans, and joint size is sufficient for multiple analyses of cartilage including biomechanical, biochemical...Read More
Electroarthrography, a non-invasive streaming potential-based method, measures cartilage quality in live horsesChangoor A, Brett W, Hoba MA, Garon M, Quenneville E, Gordon K, Savard P, Buschmann MD, Hurtig MB and Trout DROsteoarthritis and Cartilage, Vol. 22, Supplement 1, 138, World Congress on Osteoarthritis, April 2014, Paris, France.
Introduction: Degenerative joint diseases, including osteoarthritis, are characterized by progressive cartilage degeneration, which can lead to pain and loss of joint function. Therapeutics administered early, when only low grade cartilage changes have occurred, may slow or reverse disease progression, however, current clinical assessment methodologies lack the sensitivity required to provide...Read More
Non-invasive Electroarthrography Correlates to Direct Measurements of Cartilage Streaming Potentials in Weight Bearing Regions of Equine Metacarpophalangeal (Fetlock) JointsChangoor A, Hoba MA, Garon M, Quenneville E, Gordon K, Savard P, Buschmann MD and Hurtig MBTransactions of the 60th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, USA, 1123 (2014)
Introduction/Purpose: Electroarthrography (EAG) is a new technology that non-invasively measures cartilage streaming potentials through electrodes contacting the skin surrounding an articular joint. Streaming potentials are produced during cartilage compression and directly reflect cartilage composition, structure and load bearing properties. Study objectives were to develop an approach for...Read More
Freeze-dried chitosan-PRP implants improve meniscus repair in an ovine modelGhazi Zadeh L, Chevrier A, Hurtig M, Farr J, Rodeo S, Hoemann C and Buschmann MInternational Cartilage Repair Society (ICRS), Sorrento, 2016, Poster P112
Purpose: Menisci are structurally complex and play an essential weight-??bearing role in the knee joint. Although there has been a recent increase in the number of meniscus repairs performed yearly in the US [1], only a small number of all meniscal tears are repairable so that current surgical treatment of meniscal tears often involves partial meniscectomy which increases the risk of developing...Read More
