生物打印骨科材料，生物打印凝胶材料，ECM-BioInk,OsteoInk）
型号:ECM-BioInk,OsteoInk
价格:请致电：010-67529703
品牌:瑞士regenhu
BioInk® is hydrogel that promotes cell growth for different cells by providing cell
adhesion sites and
mimicking the natural extracellular matrix. Bioink® is available as a ready-to-use solution to print 3D
tissues models。
OsteoInk® is a ready-to-use calcium phosphate paste for structural engineering dedicated to
BioFactory® and 3DDiscovery® tissue printers. OsteoInk’s chemical composition (Hydroxyapatite /
tricalcium phosphate) is optimal for hard tissue engineering such than bone and cartilage. Threedimensional
printing enables freeform fabrication with controlled pore structure. BioFactory /3DDiscovery enables composite tissue printing by loading/filling the pores with bioactives such than cells /proteins /blood derivates/ hydrogels.
This portfolio is comprised of natural and synthetic hydrogels acting as extracellular-matrix environments to support cell growth (ECM-BioInk ™), biomaterials for scaffolding to mimic hard tissues (OsteoInk ™) and support materials (STARK ™).
OUR BIOMATERIALS AT A GLANCE
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Biomaterials |
Application |
Characteristics |
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HYDROGELS |
ECM-α BioInk ™ |
3D Cell culture, migration and proliferation assay |
Biosynthetic extracellular matrix with Low net charge |
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ECM-β BioInk ™ |
Biosynthetic extracellular matrix with Mid net charge |
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ECM-c BioInk ™ |
Biosynthetic charge extracellular matrix with High net charge |
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ECM-f BioInk ™ |
Biosynthetic extracellular matrix with Low net charge Functionalized |
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ECM-p BioInk ™ |
Biosynthetic extracellular matrix with Low net charge Functionalized |
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SCAFFOLDING |
OsteoInk ™ |
Calcium Phosphate biomaterial for hard tissue engineering |
Calcium phospahte formulation |
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SUPPORT |
STARK ™ |
Support material for Freeform Fabrication |
Silicon-based polymer |
Biosynthetic Hydrogels
ECM-BioInk ™, is a peptide nanofiber 3-dimensional scaffold that promotes cell growth and migration.
It utilizes specific peptides that self-assemble from ECM-BioInk ™ fluid precursors into highly intertwined hydrated peptide hydrogel fibres when presented with ionic strengths. By inducing a rapid transformation from solution to gel, a peptide nanofiber scaffold is generated.
The ECM-BioInk ™ portfolio contains 5 formulations that differ from each other in the electrical net charge which impacts the matrix stiffness and consequently cell proliferation capacity.
ECM- BioInk’s unique properties
- Synthetic (highly reproducible with no batch to batch variation)
- Adaptable matrix stiffness
- Biological building blocks
- Animal free
- Mass transport of nutrients
- Oxygen diffusion
- Bulk distribution of proteins and grow factors
- Optically transparent
- Neutral pH
- Ready to use with cells
- Electrical net charge modulation
ECM-α BioInk ™
ECM-βBioInk ™
ECM-p BioInk ™
By adjusting the concentration of the ECM-BioInk ™ solution, users can control the flexibility of the 3D architecture to meet their application′s specific needs. ECM-BioInk ™ is a unique human relevant, synthetic extracellular matrix in which scaffold interaction with cells and small molecules are driven by hydrogen and hydrophobic interactions
SELECT YOUR ECM-BioInk ™ FORMULATION
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Cell type |
ECM-α BioInk ™ |
ECM-β BioInk ™ |
ECM-c BioInk ™ |
ECM-f BioInk ™ |
ECM-p BioInk ™ |
Experiment |
|---|---|---|---|---|---|---|
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Fibroblasts |
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Proliferation, Migration |
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Human Embryonic Stem Cells |
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Proliferation, Differentiation |
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Human Induced Pluripotent Stem Cells |
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Proliferation, Differentiation |
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Human Mesenchemical Stem Cells |
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Proliferation, Differentiation |
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Bone Marrow Derived Mesenchemial Stem Cells |
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Proliferation, Differentiation |
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Adipose Tissue Derived Mesenchemical Stem Cells |
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Proliferation, Differentiation |
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Human Haemopoetic Stem Cells |
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Proliferation, Differentiation |
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Human Neuronal Stem Cells |
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Proliferation, Differentiation |
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Cardiac Progenitor Cells |
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Proliferation, Differentiation |
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Human Endothelial Cells |
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Proliferation, Migration |
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Primary Neurons |
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Proliferation, Migration |
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Cardiomyocytes |
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Proliferation, Migration |
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Nucleus Pulposus Cells |
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Proliferation, Migration |
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Hepatocytes |
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Proliferation, Migration |
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Chrondrocytes |
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Proliferation, Migration |
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Myocytes |
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Proliferation, Migration |
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Order |
Order |
Order |
Order |
Order |
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OSTEOINK™
CALCIUM PHOSPHATE MATERIAL FOR 3D TISSUE PRINTING
OsteoInk™ is a ready-to-use calcium phosphate paste for scaffolding and structural engineering. OsteoInk™ is a highly osteoconductive biomaterial close to the chemical composition of human bone. Dedicated to hard tissue engineering such as bone, cartilage or structural scaffold manufacturing, OsteoInk™ can be combined during the printing process with our biomaterial product portfolio (e.g ECM-BioInk ™) to create complex 3D tissue models.
The uniqueness of BioFactory ™ and 3DDiscovery ™printers enables freeform fabrication of tissue models with controlled layers, pore structure and biological composition. It enables scientists to mimic nature by combining OsteoInk™ with hydrogels (natural or synthetic), bioactives, scaffolding or support materials.
FACTS
- Designed for BioFactory ™ and 3DDiscovery ™tissue printers
- Osteoconductive calcium phosphate material
- For Research and Development
- Available in 5cc cartridge
- Can be combined with BioInk ™, STARK or any other type of bioactives and/or biomaterials
BioInk ™
Biosynthetic extracellular matrix
BioInk ™ is a chemically-defined hydrogel to support growth of different cell types. It allows cell adhesion, mimics the natural extracellular matrix and is biodegradable. BioInk ™ is provided as a ready-to-use chemically-defined hydrogel to print 3D tissue models. Exclusively designed for regenHU’s BioFactory ™ and 3DDiscovery ™tissue and bio-printers.
A versatile, chemically-defined hydrogel, supporting cell attachment, growth, differentiation and migration. The BioInk ™ is suitable for long-term tissue cultivation (in vitro human dermis for up to 7 weeks).
Modular Matrix Tailored to the needs of your cells
Combined with BioFactory ™ or 3DDiscovery ™tissue printers, you will be able to create composite tissue models in a layer-by-layer fashioning with spatial control of bioactive components (matrix, cells, proteins) and biomaterials.
STARK™
3D SHAPE FIDELITY FOR BIOMIMICS | BIOPOLYMER FOR SCAFFOLDING SUPPORT
Creation of tissue models of complex bioarchitectures and overhanging structures, in single or composite materials, may require fugitive support materials that act as a temporary scaffold for the structure.
Especially in 3D cell culture & LifeScience applications where extracellular matrix materials (ECM) such as low-viscose hydrogels, collagens or similar are used to encapsulate and deliver bioactives, STARK™ biopolymer enables 3D shape fidelity and bioarchitecture control of cell-laden conceptions.
STARK™ is a biocompatible biopolymer dedicated to hard & soft tissue engineering with either a 3DDiscovery™ or BioFactory™ bioprinting platform. It can be used during the construction process in combination with BioInk ™ or OsteoInk™ or any natural or synthetic printable biomaterials.
FACTS
- Designed for 3DDiscovery™ & BioFactory™ bioprinters
- Cell friendly biocompatible support material, flexible/soft and controlled hardening
- For Research & Development
- Thermosensitive cross-linking
- Can be combined with any printable biomaterial in single process approach
- Exploit full potential with Bioprinting Software Suite (BioCAM™, BioCUT™)
- Available in 3cc cartridges, ready to use single component cartridge
