多功能组织材料生物力学特性、电位分布测试分析表征系统

该系统是能集成压缩、张力、剪切、摩擦、扭转和2D/3D压痕、3D轮廓及多力混合耦连测试的一体化微观力学测试装置。能对生物组织、聚合物、凝胶、生物材料、胶囊、粘合剂和食品进行精密可靠的机械刺激和表征。允许表征的机械性能包括刚度、强度、模量、粘弹性、塑性、硬度、附着力、肿胀和松弛位移控制运动。

特点

1、适用样品范围广：

1.1、从骨等硬组织材料到脑组织、眼角膜等软组织材料

1.2、从粗椎间盘的样品到j细纤维丝

2、通高量压痕测试分析

2.1、三维法向压痕映射非平面样品整个表面的力学特性

2.2、48孔板中压痕测试分析

3、力学类型测试分析功能齐

模块化集成压缩、张力、剪切、摩擦、扭转、穿刺、摩擦和2D/3D压痕、3D表面轮廓、3D厚度等各种力学类型支持,微观结构表征及动态力学分析研究

4、高分辨率:

4.1、位移分辨率达0.1um

4.2、力分辨率达0.025mN

5、行程范围广：50-250mm

6、体积小巧、可放入培养箱内

7 、高变分辨率成像跟踪分析

8、多轴向、多力偶联刺激

9、活性组织电位分布测试分析

10、产品成熟，文献量达上千篇

纤维丝张力和扭力测
自动法向压痕和厚度映射
胫骨三维轮廓测试
机电活性材料（如结缔组织、带电水凝胶等）压缩过程中电位分布

该微观力学测试分析与培养系统初该系统为软骨力学性能检测所研发，此后集成了多种配置以满足更多生物组织和软质材料力学性能的测量和评估。该仪器卓越性能特点--模块化设计，简易操作平台，面向用户设计，广泛应用于生物材料检测，高分子材料检测以及数字教学等领域，产品得到了业界广泛的认可和推广。该系统

相比于传统的大型力学测试系统，该微观力学测试系统总体较小，可以实现桌面化的操作流程，操作过程简便。该系统测试方法面，是多样化的材料力学表征工具，是科学家、工程师和其他各领域用户的佳选择。在动态力学分析、薄膜、复合物、聚合物、生物产品、医学鉴定和水凝胶等领域都有广泛应用。

典型测试材料：

剪切相关文献：

Literature (15)

Engineering of Hyaline Cartilage with a Calcified Zone Using Bone Marrow Stromal CellsLee WD, Hurtig MB, Pilliar RM, Stanford WL and Kandel RAOsteoarthritis and Cartilage (2015), doi: 10.1016/j.joca.2015.04.010

In healthy joints, a zone of calcified cartilage (ZCC) provides the mechanical integration between articular cartilage and subchondral bone. Recapitulation of this architectural feature should serve to resist the constant shear force from the movement of the joint and prevent the delamination of tissue-engineered cartilage. Previous approaches to create the ZCC at the cartilage-substrate interface...Read More

The shear mechanical properties of diabetic and non-diabetic plantar soft tissuePai S and Ledoux WRJournal of biomechanics, 45(2), 364-370. (2012)

Changes in the plantar soft tissue shear properties may contribute to ulceration in diabetic patients, however, little is known about these shear parameters. This study examines the elastic and viscoelastic shear behavior of both diabetic and non-diabetic plantar tissue. Previously compression tested plantar tissue specimens (n = 54) at six relevant plantar locations (hallux, first, third, and fifth...Read More

Development of a Sequence of Mechanical Tests for Articular Cartilage at a Single LocationSim S, Chartrand A, Lavallee AP, Tessier J, Garon M, Quenneville E and Buschmann MDOrthopeadic Research Society Annual Meeting in Orlando, 2016

In a recent study, our group has highlighted the importance of considering the natural topographic variability of the mechanical properties over the articular surface, particularly in the context of cartilage repair, where it can screen the effect of a treatment [1]. Moreover, the availability of test sample is limited in those repair studies since the regions of interest are often limited in size....Read More

ASTM C273/C273M - Standard Test Method for Shear Properties of Sandwich MaterialsASTM International, West Conshohocken, PA, 2016, www.astm.org

Significance and Use

5.1 The shear properties are fundamental properties that are used in the design of sandwich panels. This test method provides information on the force-deflection behavior of sandwich constructions or s when loaded in shear parallel to the plane of the facings. From a complete force-deflection curve, it is possible to compute shear stress at...Read More

ASTM F2451-05 - Standard Guide for in vivo Assessment of Implantable Devices Intended to Repair or Regenerate Articular CartilageASTM International, West Conshohocken, PA, 2010, www.astm.org

Significance and Use

This guide is aimed at providing a range of in vivo models to aid in preclinical research and development of tissue engineered medical products intended for the clinical repair or regeneration of articular cartilage.
This guide includes a description of the animal models, surgical considerations, and tissue processing as well as the qualitative and quantitative...Read More

MachOne - Shear Testing on a Cartilage Disk or an Osteochondral (MA056-SOP07-D v2)Tessier J and Quenneville EBMM Inc. Laval (QC), Canada, Effective Date: August 25th, 2015

Purpose
This procedure describes a standard method to realize a planar or a torsion shear test on an articular cartilage disk or an osteochondral using the MachOneTMmechanical tester.

Scope
This procedure can be used for the ex vivo planar or torsion test on an articular cartilage or an osteochondral . It is highly...Read More

MachOne Analysis - Extraction of Mechanical Parameters Following Shear Testing on a Cartilage Disk or an Osteochondral (SW186-SOP06-D v1)Lavallée APBMM Inc. Laval (QC), Canada, Effective Date: August 19th, 2015

Purpose
This procedure describes a method to extract mechanical parameters from MachOne result files generated following shear testing on a cartilage disk or an osteochondral as per MA056-SOP07-D.

Scope
This procedure can be applied using any MachOne result file obtained following a planar shear or a torsion test on a sample. Some...Read More

Tailoring hydrogel surface properties to modulate cellular response to shear loadingMeinert C, Schrobback K, Levett PA, Lutton C, Sah R and Klein TJActa biomaterialia, October 2016. DOI: 10.1016/j.actbio.2016.10.011

Biological tissues at articulating surfaces, such as articular cartilage, typically have remarkable low-friction properties that limit tissue shear during movement. However, these frictional properties change with trauma, aging, and disease, resulting in an altered mechanical state within the tissues. Yet, it remains unclear how these surface changes affect the behaviour of embedded cells when the...Read More

Mechanical characterization of matrix-induced autologous chondrocyte implantation (MACI®) grafts in an equine model at 53 weeksGriffin DJ, Bonnevie ED, Lachowsky DJ, Hart JC, Sparks HD, Moran N and Bonassar LJJournal of biomechanics, 48(10), 1944-1949. (2015)

There has been much interest in using autologous chondrocytes in combination with scaffold materials to aid in cartilage repair. In the present study, a total of 27 animals were used to compare the performance of matrix-assisted chondrocyte implantation (MACIs) using a collagen sponge as a chondrocyte delivery vehicle, the sponge membrane alone, and empty controls. A total of three distinct types of...Read More

Change in viability of C2C12 myoblasts under compression, shear and oxidative challengesHong Y, Yao Y, Wong S, Bian L and Mak AFJournal of biomechanics, 49(8), 1305-1310. (2016)

letal and epidermal loadings can damage muscle cells and contribute to the development of deep tissue injury (DTI) – a severe kind of pressure ulcers affecting many people with disability. Important predisposing factors include the multiaxial stress and strain fields in the internal tissues, particularly the vulnerable muscles around bony prominences. A careful study of the mechanical damage thresholds...Read More

Characterization of tissue engineered cartilage products - Recent developments in advanced therapyMaciulaitis J, Rekstyte S, Usas A, Jankauskaite V, Gudas R, Malinauskas M and Maciulaitis RPharmacological Research 113 (2016) 823–832

Legislative requirements for the quality of pharmacological agents underwent certain evolution when new type of therapies emerged. This relates to cell based medicines, such as tissue engineered cartilage products (TECP) which are increasingly developed as new modalities for widely prevalent orthopaedic disorders. Although quality measures for TECP are subject to the same general regulatory quality...Read More

Review Paper: Fifty years of brain tissue mechanical testing: From in vitro to in vivo investigationsChatelin S, Constantinesco A and Willinger RBiorheology 47 (2010) 255–276. DOI 10.3233/BIR-2010-0576

Beginning in the 1960s many studies have been performed to investigate the mechanical properties of brain. In this paper we point out the difficulties linked with in vitro experimental protocols as well as the advantages of using recently developed non-invasive in vivo techniques, such as magnetic resonance elastography. Results of in vitro and in vivo work are compared, emphasizing the specificities...Read More

Combined Mechanical Characterizations Increases Sensitivity in the Assessment of Human Cartilage DegenerationSim S, Hadjab I, Chevrolat L-A, Masse M, Tong AL, Lavigne P, Garon M, Quenneville E and Buschmann MDAccepted for a podium presentation at ORS 2017

Introduction: We published a recent study showing superior sensitivity of electromechanical and indentation (instantaneous response) assessments versus well-established techniques, including histological Mankin s, to characterize cartilage degeneration. This study aims to determine whether the combination of instantaneous, relaxation and equilibrium mechanical properties and friction...Read More

Autonomously Self-Adhesive Hydrogels as Building Blocks for Additive ManufacturingDeng X, Attalla R, Sadowski LP, Chen M, Majcher MJ, Urosev I, Yin D-C, Selvaganapathy PR, Filipe CDM and Hoare TBiomacromolecules 2017, Published Online, doi: 10.1021/acs.biomac.7b01243

We report a simple method of preparing autonomous and rapid self-adhesive hydrogels and their use as building blocks for additive manufacturing of functional tissue scaffolds. Dynamic crosslinking between 2-aminophenylboronic acid-functionalized hyaluronic acid and poly(vinyl alcohol) yields hydrogels that recover their mechanical integrity within one minute after cutting or shear under both neutral...Read More

Quantitative Analysis of Tissue Damage Evolution in Porcine Liver With Interrupted Mechanical Testing Under Tension, Compression, and Shear.Chen J, Brazile B, Prabhu R, Patnaik SS, Bertucci R, Rhee H, Horstemeyer MF, Hong Y, Williams LN, Liao JJ Biomech Eng. 2018 Jul 1;140(7). doi: 10.1115/1.4039825.

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