| 产品标题 |
产品货号 |
产品规格 |
厂家 |
| VH298 | Axon 2810
CAS [2097381-85-4]
MF C27H33N5O4SMW 523.65
Purity:
98%
Soluble in DMSO
Description
VH298 is a potent and selective VHL inhibitor (Kd value of 80-90 nM) that stabilizes HIF-α and elicits a hypoxic response via the blockade of the VHL:HIF-α protein–protein interaction downstream of HIF-α hydroxylation by PHD enzymes.
KEYWORDS: VH298 | supplier | VHL inhibitor | VH-298 | VH 298 | CAS [2097381-85-4] | Smad | Ubiquitin Ligase (E3; VHL) | Inhibitor | Enzymes | von-Hippel-Lindau | prolyl hydroxylase | PHD | | axonmedchem |
| SB 277011A - SB 277011 dihydrochloride | Axon 1920
CAS [1226917-67-4]
MF C28H30N4O.2HClMW 511.49
Purity:
99%
Soluble in water and DMSO
Description
Potent, selective and brain penetrating D3 dopamine receptor antagonist; with high affinity for the hD3 receptor (pKi = 7.95) and 100-fold selectivity over the hD2 receptor and over 66 other receptors.
KEYWORDS: SB 277011A | supplier | D3 antagonist | SB 277011 dihydrochloride | SB277011A | SB277011 | CAS [1226917-67-4] | [215803-78-4] | Dopamine | GPCR | drug addiction | | axonmedchem |
| JNJ 37822681 dihydrochloride | Axon 1802
CAS [935776-74-2]
MF C17H17F5N4.2HClMW 445.26
Purity:
98%
Soluble in water and DMSO
Description
Potent and selective dopamine D2 receptor antagonist; centrally acting and fast-dissociating ligand; potentially an antipsychotic agent
References
Certificates
Categories
Extra info
X Langlois et al. Pharmacology of JNJ-37822681, a specific and fast-dissociating D2 antagonist for the treatment of schizophrenia. J. Pharmacol. Exp. Ther. 2012, 342(1), 91-105.
ET te Beek et al. Pharmacokinetics and central nervous system effects of the novel dopamine D2 receptor antagonist JNJ-37822681. J. Psychopharmacol. 2012, 26(8), 1119-1127.
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
A17
D2 antagonist
Chemical name
N-(1-(3,4-difluorobenzyl)piperidin-4-yl)-6-(trifluoromethyl)pyridazin-3-amine
Parent CAS No.
[935776-74-2]
Order
Size
Unit Price
Stock
10 mg
€135.00
In Stock | | axonmedchem |
| Droperidol - R 4749 | Droleptan | Dridol | Axon 1554
CAS [548-73-2]
MF C22H22FN3O2MW 379.43
Purity:
99%
Soluble in DMSO
Description
Dopamine D2 receptor antagonist and α1 adrenoceptor antagonist; an antidopaminergic drug used as an antiemetic and antipsychotic; also often used for neuroleptanalgesic anesthesia and sedation in intensive-care treatment
References
Certificates
Categories
Extra info
S Purhonen et al. Comparison of tropisetron, droperidol, and saline in the prevention of postoperative nausea and vomiting after gynecologic surgery. Anesth Analg 1997, 84(3), 662-667.
SJ Wang et al. Droperidol treatment of status migrainosus and refractory migraine. Headache 1997, 37(6), 377-382.
M Koivuranta et al. The antiemetic efficacy of a combination of ondansetron and droperidol. Anaesthesia 1997, 52(9), 863-868.
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
A17
D2 and α1 adrenoceptor antagonist
Chemical name
1-{1-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-1,2,3,6-tetrahydro-pyridin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Parent CAS No.
[548-73-2]
Order
Size
Unit Price
Stock
10 mg
€55.00
In Stock | | axonmedchem |
| Ropinirole hydrochloride | Axon 1514
CAS [91374-20-8]
MF C16H24N2O.HClMW 296.84
Purity:
98%
Soluble in water and DMSO
Description
A non-ergoline D2, D3, and D4 dopamine receptor agonist with highest affinity for D3; with moderate in vitro affinity for the opioid receptors
References
Certificates
Categories
Extra info
G. Gallagher Jr. et al. 4-[2-(Di-n-propylamino)ethyl]-2(3H)-indolone: a prejunctional dopamine receptor agonist. J. Med. Chem. 1985, 28, 1533-1536.
S. Giménez-Roldán et al. Ropinirol: a new dopamine agonist in the treatment of Parkinson's disease. Neurologia. 1997, 12, 354-361.
R.S. Kakar et al. Ropinirole in the treatment of restless legs syndrome. Expert Rev. Neurother. 2005, 5, 35-42.
Certificate of Analysis
Material Safety Data Sheet
CNS
Pain & Inflammation
Endocrinology
D3
A17
D2, D3 and D4 agonist
Chemical name
4-(2-Dipropylamino-ethyl)-1,3-dihydro-indol-2-one
Parent CAS No.
[91374-21-9]
Order
Size
Unit Price
Stock
10 mg
€70.00
In Stock | | axonmedchem |
| NNC 756 - Odapipam | Axon 1405
CAS [131796-63-9]
MF C19H20ClNO2MW 329.82
Purity:
99%
Optical purity:
99% ee
Soluble in DMSO
Description
Very potent dopamine D1 antagonist.
References
Certificates
Categories
Extra info
EB Nielsen, PH Andersen. Dopamine receptor occupancy in vivo: behavioral correlates using NNC-112, NNC-687 and NNC-756, new selective dopamine D1 receptor antagonists. Eur. J. Pharmacol. 1992, 219(1), 35-44; ibid 45-52.
A Abi-Dargham et al. PET studies of binding competition between endogenous dopamine and the D1 radiotracer [11C]NNC 756. Synapse. 1999, 32(2), 93-109.
Certificate of Analysis
Material Safety Data Sheet
CNS
D1
A17
D1 antagonist
Chemical name
(S)-(+)-8-Chloro-5-(2,3-dihydro-benzofuran-7-yl)-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol
Parent CAS No.
[131796-63-9]
Order
Size
Unit Price
Stock
5 mg
€135.00
In Stock | | axonmedchem |
| GR 103691 | Axon 1347
CAS [162408-66-4]
MF C30H35N3O3MW 485.62
Purity:
99%
Moderately soluble in DMSO
Description
Dopamine D3 receptor antagonist
References
Certificates
Categories
Extra info
V Audinot et al. A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194. J. Pharmacol. Exp. Ther. 1998, 287, 187-197.
Certificate of Analysis
Material Safety Data Sheet
CNS
D3
A17
D3 antagonist
Chemical name
4'-Acetyl-biphenyl-4-carboxylic acid {4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-amide
Parent CAS No.
[162408-66-4]
Order
Size
Unit Price
Stock
10 mg
€85.00
In Stock | | axonmedchem |
| ACR16 hydrochloride - Pridopidine hydrochloride | Axon 1579
CAS [882737-42-0]
MF C15H23NO2S.HClMW 317.87
Purity:
99%
Soluble in water and DMSO
Description
Dopaminergic stabilizer (Ki values 17550 nM and 7521 for D2(low) and D2(high), respectively) that state-dependently stabilizes psychomotor activity by the dual actions of functional dopamine D2 receptor antagonism and strengthening of cortical glutamate functions in various settings of perturbed neurotransmission. Useful for ameliorating several neurological and psychiatric disorders, including Huntington's disease.
Note | | axonmedchem |
| ST 198 | Axon 1343
CAS [854924-64-4]
MF C22H26N2OMW 334.45
Purity:
99%
No solubility data
Description
Dopamine D3 receptor antagonist
References
Certificates
Categories
Extra info
P Pyrko. HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress. Cancer Res. 2007, 67, 10920–8.
JJ Gills et al. Nelfinavir, A Lead HIV Protease Inhibitor, Is a Broad-Spectrum, Anticancer Agent that Induces Endoplasmic Reticulum Stress, Autophagy, and Apoptosis In vitro and In vivo. Clin. Cancer Res. 2007, 13(17), 5183–5194.
WA Chow et al. Anti-HIV drugs for cancer therapeutics: back to the future?. Lancet Oncol. 2009, 10 (1), 61–71.
Certificate of Analysis
Material Safety Data Sheet
CNS
D3
A17
D3 antagonist
Chemical name
(E)-N-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-butyl]-3-phenyl-acrylamide
Parent CAS No.
[854924-64-4]
Order
Size
Unit Price
Stock
10 mg
€99.00
In Stock | | axonmedchem |
| ST 148 | Axon 1342
CAS [390803-40-4]
MF C27H36N4O3S.C4H4O4MW 612.74
Purity:
99%
Soluble in DMSO and Ethanol
Description
Dopamine D2 receptor antagonist; with improved selectivity for hD2L receptors
References
Certificates
Categories
Extra info
B Weber et al. Identification of the dopamine autoreceptor in the guinea-pig retina as D2 receptor using novel subtype-selective antagonists. Br. J. Pharmacol. 2001, 133, 1243-1248.
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
A17
D2 antagonist
Chemical name
5-Dimethylamino-naphthalene-1-sulfonic acid {4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-amide maleate
Parent CAS No.
[390803-39-1]
Order
Size
Unit Price
Stock
10 mg
€115.00
In Stock | | axonmedchem |
| B-HT 958 dihydrochloride | Axon 1337
CAS [36085-44-6]
MF C14H16ClN3S.2HClMW 366.74
Purity:
99%
Soluble in water
Description
Dopamine D2 receptor agonist, α2-adrenoceptor partial agonist
References
Certificates
Categories
Extra info
MJ Brown and D Harland. B-HT 958 lowers blood pressure and heart rate in the rat through stimulation of dopamine receptors. Br. J. Pharmacol. 1986, 87(2), 361–370.
G Cichini et al. B-HT 920 and B-HT 958: Presynaptic effects on electrically evoked 3H-dopamine release from slices of rat nucleus accumbens. Naunyn-Schmiedeberg's Arch. Pharmacol. 1987, 335, 28-31.
L Pichler et al. B-HT 958, a new α-adrenoceptor agonist with a high pre/postsynaptic activity ratio. Naunyn-Schmiedeberg's Arch. Pharmacol. 1982, 320, 2, 110-114.
Hörtnagl H et al. B-HT 958--an antagonist at alpha 2-adrenoceptors and an agonist at dopamine autoreceptors in the brain. Eur. J. Pharmacol. 1984, 106(2), 335-344.
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
Adrenoceptor α2
A17
D2 agonist; α2 adrenoceptor agonist
Chemical name
6-(4-Chloro-benzyl)-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-ylamine dihydrochloride
Parent CAS No.
[83718-64-3]
Order
Size
Unit Price
Stock
10 mg
€95.00
In Stock | | axonmedchem |
| Ethylnorapomorphine hydrochloride, R(-)-N- | Axon 1162
CAS [123240-93-7]
MF C18H19NO2.HBrMW 362.26
Purity:
99%
Optical purity:
>98% ee
No solubility data
Description
Dopamine D2 receptor agonist; more potent than R(-)-NPA (Axon 1161)
References
Certificates
Categories
Extra info
CNS
D2
A17
D2 agonist
Chemical name
(R)-6-Ethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol hydrobromide
Parent CAS No.
[18426-16-9]
Inquire | | axonmedchem |
| Molindone hydrochloride - EN 1733A | Axon 1101
CAS [15622-65-8]
MF C16H24N2O2.HClMW 312.83
Purity:
99%
Soluble in DMSO
Description
D2 dopamine receptor antagonist; MAO inhibitor; a therapeutic antipsychotic, used in the treatment of schizophrenia; Reduction of body weight reported. Terminal plasma half-life after oral administration about 6½ hours
References
Certificates
Categories
Extra info
A Bagnall et al. Molindone for schizophrenia and severe mental illness. Cochrane Database Syst. Rev. 2007, 1, CD002083.
DB Allison et al. Antipsychotic-induced weight gain: a comprehensive research synthesis. Am. J. Psychiatry 1999, 156(11), 1686–1696.
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
A17
D2 antagonist; MAO inhibitor
Chemical name
3-Ethyl-2-methyl-5-morpholin-4-ylmethyl-1,5,6,7-tetrahydro-indol-4-one hydrochloride
Parent CAS No.
[7416-34-4]
Order
Size
Unit Price
Stock
10 mg
€85.00
In Stock | | axonmedchem |
| Propylnorapomorphine hydrobromide, R(-)-N- - NPA | Axon 1161
CAS [85199-01-5]
MF C19H21NO2.HBrMW 376.29
Purity:
99%
Optical purity:
>98% ee
Soluble in 0.1N HCl(aq) and DMSO
Description
Highly potent and selective dopamine D2 receptor agonist
References
Certificates
Categories
Extra info
Creese et al. 3H-N-n-propylnorapomorphine: A novel agonist ligand for central dopamine receptors. Eur. J. Pharmacol. 1979, 56, 411.
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
A17
D2 agonist
Chemical name
(R)-6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol hydrobromide
Parent CAS No.
[18426-20-5]
Order
Size
Unit Price
Stock
10 mg
€95.00
In Stock | | axonmedchem |
| B-HT 920 dihydrochloride - Talipexole | Axon 1153
CAS [36085-73-1]
MF C10H15N3S.2HClMW 282.23
Purity:
99%
Soluble in water and DMSO
Description
Dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist.
KEYWORDS: B-HT 920 dihydrochloride | supplier | α2 and D2 agonist | Talipexole | BHT920 HCl | CAS [36085-73-1] | [101626-70-4] | Dopamine | D2 | Adrenoceptor alpha2 | 5-HT3 | serotonin | CNS | GPCR | autoreceptors | parkinson's | brain | | axonmedchem |
| PD 128907 hydrochloride, (±)- - PD 125530 | Axon 1072
CAS [123594-64-9]
MF C14H19NO3.HClMW 285.77
Purity:
99%
Soluble in DMSO
Description
Selective D3 dopamine receptor agonist. Its more active enantiomer is trans-(+)-PD-128907 (Axon 1073) and less active enantiomer is (-)-PD 128907 (Axon 1074)
References
Certificates
Categories
Extra info
Pugsley et al. Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907. J. Pharmacol. Exp. Ther. 1995, 275 1355.
G.N. Bancroft et al. Binding of [3H]PD 128907, a Putatively Selective Ligand for the D3 Dopamine Receptor, in Rat Brain: A Receptor Binding and Quantitative Autoradiographic Study. Neuropsychopharmacol. 1998, 18, 305-316.
Certificate of Analysis
Material Safety Data Sheet
CNS
D3
A17
D3 agonist
Chemical name
trans-(+/-)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4,9-dioxa-1-aza-phenanthren-6-ol hydrochloride
Parent CAS No.
[123594-64-9]
Order
Size
Unit Price
Stock
5 mg
€95.00
In Stock | | axonmedchem |
| PHNO hydrochloride, (+)- - Naxagolide | Dopazinol | Axon 1071
CAS [99705-65-4]
MF C15H21NO2.HClMW 283.79
Purity:
99%
Optical purity:
>98% ee
Soluble in water and DMSO
Description
Very potent and selective D2 agonist, more active enantiomer. Note: Appropriate chiral precursor(s) for making D2 radiotracer, [11C]-(+)-PHNO, can be provided on request.
KEYWORDS: (+)-PHNO hydrochloride | supplier | D2 agonist | Naxagolide | Dopazinol | PHNO |CAS[99705-65-4] | [88058-88-2] | Dopamine | D2 | Agonist | radiotracer | enantiomer | | axonmedchem |
| PHNO hydrochloride, (±)- | Axon 1070
CAS [100935-99-7]
MF C15H21NO2.HClMW 283.79
Purity:
98%
Optical purity:
racemic, trans
Soluble in water and DMSO
Description
Potent and selective D2 agonist, racemate of PHNO, its more active enantiomer is (+)-PHNO (Axon 1071)
References
Certificates
Categories
Extra info
Martin et al. Selectivity of (+)-4-propyl-9-hydroxynaphthoxazine [(+)-PHNO] for dopamine receptors in vitro and in vivo. J. Pharmacol. Exp. Ther. 1985, 233, 2, 395-401
CNS
D2
A17
D2 agonist; racemate of PHNO (Axon 1071)
Chemical name
trans-(+/-)-4-Propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol hydrochloride
Parent CAS No.
[88058-85-9]
Inquire | | axonmedchem |
| PD 128907 hydrochloride, (-)- | Axon 1074
CAS [112960-16-4 ]
MF C14H19NO3.HClMW 285.77
Purity:
99%
Optical purity:
99% ee
No solubility data
Description
PD 128907 is a selective D3 dopamine receptor agonist; (-)-enantiomer is less active in comparison with (+)-enantiomer (Axon 1073). The racemic product, (±)-PD 128907 hydrochloride, is available as Axon 1072.
References
Certificates
Categories
Extra info
Pugsley et al. Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907. J. Pharmacol. Exp. Ther. 1995, 275 1355.
Witkin et al. Atypical antipsychotic-like effects of the dopamine D3 receptor agonist (+)-PD 128907. Eur. J. Pharmacol. 1998, 347, R1.
CNS
D3
A17
D3 agonist
Chemical name
(4aS,10aS)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4,9-dioxa-1-aza-phenanthren-6-ol hydrochloride
Parent CAS No.
[123671-93-2]
Inquire | | axonmedchem |
| U 99194 maleate | Axon 1069
CAS [234757-41-6]
MF C17H27NO2.C4H4O4MW 393.47
Purity:
99%
Soluble in water
Description
Selective and potent D3 antagonist with a 30-fold preference for the dopamine D3 vs D2 receptor
References
Certificates
Categories
Extra info
T Kling-Petersen et al. Effects on locomotor activity after local application of D3 preferring compounds in discrete areas of the rat brain. J. Neural Transm. 1995, 102, 209-220.
V Audinot et al. A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194. J. Pharmacol. Exp. Ther. 1998, 287, 187-197.
Certificate of Analysis
Material Safety Data Sheet
CNS
D3
A17
D3 antagonist
Chemical name
(5,6-Dimethoxy-indan-2-yl)-dipropyl-amine maleate
Parent CAS No.
[82668-33-5]
Order
Size
Unit Price
Stock
10 mg
€80.00
In Stock | | axonmedchem |
| PPHT hydrochloride, (R)- - (R)-N 0434 | Axon 1036
CAS [161757-96-6]
MF C21H27NO.HClMW 345.91
Purity:
100%
Optical purity:
>98% ee
Soluble in water and DMSO
Description
(R)-enantiomer of PPHT (Axon 1035), a very potent and specific D2 agonist
References
Certificates
Categories
Extra info
J van der Weide et al. Pharmacological profiles of three new, potent and selective dopamine receptor agonists: N-0434, N-0437 and N-0734. Eur. J. Pharmacol. 1986, 125, 273-282.
P Seeman et al. Dopamine D2 receptor binding sites for agonists. A tetrahedral model. Mol. Pharmacol. 1985, 28, 391.
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
A17
(R)-enantiomer of PPHT (Axon 1035); D2 agonist
Chemical name
(R)-6-(Phenethyl-propyl-amino)-5,6,7,8-tetrahydro-naphthalen-1-ol hydrochloride
Parent CAS No.
[129389-27-1]
Inquire | | axonmedchem |
| PPHT hydrochloride - N 0434 | Axon 1035
CAS [71787-90-1]
MF C21H27NO.HClMW 345.91
Purity:
98%
Soluble in DMSO
Description
Very Potent and specific D2 agonist.
KEYWORDS: PPHT hydrochloride | D2 agonist | N 0434 | PPHT | N0434 | CAS [71787-90-1] | [87857-27-0] | Dopamine | D2 | Agonist | Receptors | | axonmedchem |
| Hydroxy-DPAT hydrochloride, (S)-(-)-7- - DPAT, (S)-7-OH- | Axon 1014
CAS [93503-07-2]
MF C16H25NO.HClMW 283.84
Purity:
99%
Optical purity:
98% ee
Soluble in water and DMSO
Description
D3 dopamine receptor agonist; less active enantiomer of 7-OH-DPAT (Axon 1012), in comparison with (R)-(+)-7-OH-DPAT (Axon 1013)
References
Certificates
Categories
Extra info
G Damsma et al. Pharmacological aspects of R-(+)-7-OH-DPAT, a putative dopamine D3 ligand. Eur. J. Pharmacol. 1993, 249, R9-R10.
LM Pritchard et al. 7-OH-DPAT and PD 128907 Selectively Activate the D3 Dopamine Receptor in a Novel Environment. Neuropsychopharmacology 2003, 28, 100–107.
Seeman and Van Tol. Dopamine receptor pharmacology. TiPS 1994, 15, 264.
Certificate of Analysis
Material Safety Data Sheet
CNS
D3
A17
D3 agonist
Chemical name
(S)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol hydrochloride
Parent CAS No.
[82730-73-2]
Order
Size
Unit Price
Stock
5 mg
€115.00
In Stock | | axonmedchem |
| Hydroxy-DPAT hydrobromide, (R)-(+)-7- - DPAT, (R)-7-OH- | Axon 1013
CAS [1021878-34-1]
MF C16H25NO.HBrMW 328.29
Purity:
98%
Optical purity:
98% ee
Soluble in DMSO
Description
A Putative D3 dopamine receptor agonist (D3>D2>>D4 and D1); more active enantiomer of 7-OH-DPAT (Axon 1012), in comparison with (S)-(-)-7-OH-DPAT (Axon 1014)
References
Certificates
Categories
Extra info
G Damsma et al. Pharmacological aspects of R-(+)-7-OH-DPAT, a putative dopamine D3 ligand. Eur. J. Pharmacol. 1993, 249, R9-R10.
LM Pritchard et al. 7-OH-DPAT and PD 128907 Selectively Activate the D3 Dopamine Receptor in a Novel Environment. Neuropsychopharmacology 2003, 28, 100–107.
Seeman and Van Tol. Dopamine receptor pharmacology. TiPS 1994, 15, 264.
Certificate of Analysis
Material Safety Data Sheet
CNS
D3
A17
D3 agonist
Chemical name
(R)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol hydrobromide
Parent CAS No.
[82730-72-1]
Inquire | | axonmedchem |
| Hydroxy-DPAT hydrobromide, 7- - DPAT, 7-OH- | Axon 1012
CAS [76135-30-3]
MF C16H25NO.HBrMW 328.29
Purity:
98%
Soluble in DMSO
Description
D3 dopamine receptor agonist (D3>D2>>D4 and D1)
References
Certificates
Categories
Extra info
LM Pritchard et al. 7-OH-DPAT and PD 128907 Selectively Activate the D3 Dopamine Receptor in a Novel Environment. Neuropsychopharmacology 2003, 28, 100–107.
Seeman and Van Tol. Dopamine receptor pharmacology. TiPS 1994, 15, 264.
Certificate of Analysis
Material Safety Data Sheet
CNS
D3
A17
D3 agonist
Chemical name
7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol hydrobromide
Parent CAS No.
[74938-11-7]
Order
Size
Unit Price
Stock
10 mg
€55.00
In Stock | | axonmedchem |
| PPHT hydrochloride, (S)- - N 0434, (S)- | Axon 1037
CAS [159795-62-7]
MF C21H27NO.HClMW 345.91
Purity:
98%
Optical purity:
>98% ee
No solubility data
Description
(S)-enantiomer of PPHT (Axon 1035), a very potent and specific D2 agonist
References
Certificates
Categories
Extra info
J van der Weide et al. Pharmacological profiles of three new, potent and selective dopamine receptor agonists: N-0434, N-0437 and N-0734. Eur. J. Pharmacol. 1986, 125, 273-282.
P Seeman et al. Dopamine D2 receptor binding sites for agonists. A tetrahedral model. Mol. Pharmacol. 1985, 28, 391.
CNS
D2
A17
(S)-enantiomer of PPHT (Axon 1035); D2 agonist
Chemical name
(S)-6-(Phenethyl-propyl-amino)-5,6,7,8-tetrahydro-naphthalen-1-ol hydrochloride
Parent CAS No.
[129389-79-0]
Inquire | | axonmedchem |
| Hydroxy-DPAT hydrobromide, (S)-5- - DPAT, (S)-5-OH- | Axon 1008
CAS [182210-74-8]
MF C16H25NO.HBrMW 328.29
Purity:
98%
Optical purity:
>98% ee
Soluble in DMSO
Description
Potent and selective dopamine (DA) D2-receptor agonist; more active (S)- enantiomer of 5-OH-DPAT (Axon 1006); its opposite enantiomer, R-5-OH-DPAT (Axon 1007), is a weakly potent D2 antagonist
References
Certificates
Categories
Extra info
A. Karlsson et al. (R)- and (S)-5-hydroxy-2-(dipropylamino)tetralin (5-OH DPAT): Assessment of optical purities and dopaminergic activities. Chirality. 1989-1995, 2(2), 90-95.
B Shi et al. Radiosynthesis and in vitro evaluation of 2-(N-alkyl-N-1'-11C-propyl)amino-5-hydroxytetralin analogs as high affinity agonists for dopamine D-2 receptors.Nucl Med Biol. 1999, 26(7), 725-35. (PubMed)
J Mukherjee et al. In vitro and in vivo evaluation of the binding of the dopamine D2 receptor agonist (11)C-(R,S)-5-hydroxy-2-(di-n-propylamino)tetralin in rodents and nonhuman primate.Synapse. 2000, 37(1), 64-70. (PubMed)
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
A17
D2 agonist
Chemical name
(S)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol hydrobromide
Parent CAS No.
[68643-08-3]
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Size
Unit Price
Stock
5 mg
€145.00
In Stock | | axonmedchem |
| Hydroxy-DPAT hydrobromide, 5- - DPAT, 5-OH- | Axon 1006
CAS [71787-83-2]
MF C16H25NO.HBrMW 328.29
Purity:
99%
Soluble in water and DMSO
Description
Potent and selective dopamine (DA) D2-receptor agonist; [11C]5-OH-DPAT is being developed as a PET agent for the high-affinity state of D2/3 receptors
References
Certificates
Categories
Extra info
A. Karlsson et al. (R)- and (S)-5-hydroxy-2-(dipropylamino)tetralin (5-OH DPAT): Assessment of optical purities and dopaminergic activities. Chirality. 1989-1995, 2(2), 90-95.
A.K. Nugroho et al. Transdermal iontophoresis of the dopamine agonist 5-OH-DPAT in human skin in vitro. J. Controlled Release 2005, 103(2), 393-403.
B Shi et al. Radiosynthesis and in vitro evaluation of 2-(N-alkyl-N-1'-11C-propyl)amino-5-hydroxytetralin analogs as high affinity agonists for dopamine D-2 receptors.Nucl Med Biol. 1999, 26(7), 725-35. (PubMed)
J Mukherjee et al. In vitro and in vivo evaluation of the binding of the dopamine D2 receptor agonist (11)C-(R,S)-5-hydroxy-2-(di-n-propylamino)tetralin in rodents and nonhuman primate.Synapse. 2000, 37(1), 64-70. (PubMed)
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
A17
D2 agonist
Chemical name
6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol hydrobromide
Parent CAS No.
[68593-96-4]
Order
Size
Unit Price
Stock
5 mg
€105.00
In Stock | | axonmedchem |
| Hydroxy-DPAT hydrobromide, (R)-5- - DPAT, (R)-5-OH- | Axon 1007
CAS [182210-73-7]
MF C16H25NO.HBrMW 328.29
Purity:
98%
Optical purity:
>98% ee
Soluble in DMSO
Description
While racemic 5-OH-DPAT (Axon 1006) is a potent and selective dopamine (DA) D2-receptor agonist, its R-enantiomer, (R)-5-OH DPAT is a weakly potent DA D2-receptor antagonist
References
Certificates
Categories
Extra info
A Karlsson et al. (R)- and (S)-5-hydroxy-2-(dipropylamino)tetralin (5-OH DPAT): Assessment of optical purities and dopaminergic activities. Chirality. 1989-1995, 2(2), 90-95.
S.L. Payne et al. Mechanisms of ligand binding and efficacy at the human D2(short) dopamine receptor. J. Neurochem. 2002, 82, 1106–1117.
Certificate of Analysis
Material Safety Data Sheet
CNS
D2
A17
D2 antagonist
Chemical name
(R)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol hydrobromide
Parent CAS No.
[69367-51-7]
Order
Size
Unit Price
Stock
5 mg
€145.00
In Stock | | axonmedchem |
| RU 24213 | Axon 1003
CAS [67383-44-2]
MF C19H25NO.HClMW 319.87
Purity:
98%
No solubility data
Description
Dopamine D2 receptor agonist; also kappa opioid receptor antagonist
References
Certificates
Categories
Extra info
H. Ujike et al. D-2 but not D-1 dopamine agonists produce augmented behavioral response in rats after subchronic treatment with methamphetamine or cocaine. Psychopharmacology 1990, 102, 459-464.
M. Fortin et al. The dopamine D2 agonists RU 24213 and RU 24926 are also kappa-opioid receptor antagonists. Neuropharmacology. 1991, 30(4), 409-12.
Certificate of Analysis
Material Safety Data Sheet
CNS
Pain & Inflammation
Endocrinology
D2
A17
D2 agonist
Chemical name
3-[2-(Phenethyl-propyl-amino)-ethyl]-phenol hydrochloride
Parent CAS No.
[315209-09-7]
Order
Size
Unit Price
Stock
10 mg
€105.00
In Stock | | axonmedchem |
| LE 135 | Axon 1242
CAS [155877-83-1]
MF C29H30N2O2MW 438.56
Purity:
98%
Soluble in DMSO
Description
Retinoid antagonist, β type selective
References
Certificates
Categories
Extra info
Li et al Identification of a novel class of retinoic acid receptor β-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells. J. Biol. Chem.1999, 274. 15360.
Certificate of Analysis
Material Safety Data Sheet
Miscellaneous
Retinoic Acid (RAR)
NR1B
RAR antagonist
Chemical name
4-(5,7,7,10,10-Pentamethyl-7,8,9,10-tetrahydro-5H-5,12-diaza-benzo[4,5]cyclohepta[1,2-b]naphthalen-13-yl)-benzoic acid
Parent CAS No.
[155877-83-1]
Order
Size
Unit Price
Stock
10 mg
€95.00
In Stock | | axonmedchem |
| CH 55 | Axon 1241
CAS [110368-33-7]
MF C24H28O3MW 364.48
Purity:
99%
Soluble in DMSO and Ethanol
Description
Potent retinoic acid receptor (RAR) agonist
References
Certificates
Categories
Extra info
Sato et al. Functional studies of newly synthesized benzoic acid derivatives: identification of highly potent retinoid-like activity. J. Cell. Physiol. 1988, 135, 179.
Certificate of Analysis
Material Safety Data Sheet
Miscellaneous
Retinoic Acid (RAR)
NR1B
RAR agonist
Chemical name
4-[(E)-3-(3,5-Di-tert-butyl-phenyl)-3-oxo-propenyl]-benzoic acid
Parent CAS No.
[110368-33-7]
Order
Size
Unit Price
Stock
10 mg
€90.00
In Stock | | axonmedchem |
| BMS 270394 - BMS 270394, (R)-(+)- | Axon 1173
CAS [262433-54-5]
MF C23H26FNO4MW 399.46
Purity:
99%
Optical purity:
>98% ee
Soluble in DMSO and Ethanol
Description
Nuclear retinoic acid receptor (RAR-γ) agonist; more active enantiomer of BMS 189961 (Axon 1194)
KEYWORDS: BMS 270394 | supplier | RAR-γ agonist | (R)-(+)-BMS 270394 | BMS270394 | CAS [262433-54-5] | Retinoic Acid | RAR-gamma | Agonist | Receptor | active enantiomer | BMS 189961 | BMS189961 | | axonmedchem |
| BMS 189961 - BMS 961 | Axon 1194
CAS [185629-22-5]
MF C23H26FNO4MW 399.46
Purity:
98%
Soluble in DMSO
Description
Nuclear retinoic acid receptor (RAR-γ) agonist; its more active (R)-(+)-enantiomer is BMS 270394 (Axon 1173)
References
Certificates
Categories
Extra info
B P Klaholz et al. Enantiomer Discrimination Illustrated by High-Resolution Crystal Structures of the Human Nuclear Receptor hRARγ. Proc. Natl. Acad. Sci. USA. 2000, 97(12), 6322–6327.
Certificate of Analysis
Material Safety Data Sheet
Miscellaneous
Retinoic Acid (RAR)
NR1B
RAR-γ agonist
Chemical name
3-Fluoro-4-[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-acetylamino]-benzoic acid
Parent CAS No.
[185629-22-5]
Order
Size
Unit Price
Stock
10 mg
€145.00
In Stock | | axonmedchem |
| CP 226269 | Axon 1521
CAS [220941-93-5]
MF C18H19FN4MW 310.37
Purity:
99%
Soluble in DMSO
Description
Selective dopamine D4 agonist; highly recommended tool for researching the role of D4 receptor in the brain
References
Certificates
Categories
Extra info
A Sharma et al. D4 dopamine receptor-mediated phospholipid methylation and its implications for mental illnesses such as schizophrenia. Mol. Psychiatry 1999, 4(3), 235–46.
AM Basso et al. Antidepressant-like effect of D2/3 receptor-, but not D4 receptor-activation in the rat forced swim test. Neuropsychopharmacol. 2005, 30(7), 1257–68.
Certificate of Analysis
Material Safety Data Sheet
CNS
D4
A17
D4 agonist
Chemical name
5-Fluoro-2-(4-pyridin-2-yl-piperazin-1-ylmethyl)-1H-indole
Parent CAS No.
[220941-93-5]
Order
Size
Unit Price
Stock
5 mg
€85.00
In Stock | | axonmedchem |
| AR7 - Atypical retinoid 7 | Axon 2679
CAS [80306-38-3]
MF C15H12ClNOMW 257.71
Purity:
99,7%
Soluble in DMSO
Description
Atypical RARα receptor antagonist that stimulates CMA (chaperone-mediated autophagy) activity without detectable changes in other autophagic pathways, making cells more resistant to oxidative stress and proteotoxicity. AR7 is also known as a hypoxia targeted compound for cancer therapeutics (IC50 value 10 μM for inhibition of hypoxic cancer cell growth (MTT assay) in HepG2 cells while sparing ‘normoxic’ cells).
KEYWORDS: AR7 | supplier | RARα antagonist | Atypical retinoid 7 | AR-7 | AR 7 | CAS [80306-38-3] | Retinoic Acid | nuclear receptor | NR1B1 | chaperone-mediated | autophagy | CMA | hypoxia | cancer | neurodegenerative | | axonmedchem |
| ABT 724 trihydrochloride | Axon 1250
CAS [587870-77-7]
MF C17H19N5.3HClMW 402.75
Purity:
99%
Soluble in water
Description
Dopamine D4 partial agonist
References
Certificates
Categories
Extra info
Brioni et al. Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats. Proc. Natl. Acad. Sci. USA 2004. 101, 6758.
Certificate of Analysis
Material Safety Data Sheet
CNS
D4
A17
D4 agonist
Chemical name
2-(4-Pyridin-2-yl-piperazin-1-ylmethyl)-1H-benzoimidazole trihydrochloride
Parent CAS No.
[70006-24-5]
Order
Size
Unit Price
Stock
10 mg
€85.00
In Stock | | axonmedchem |
| Spautin 1 - MBCQ derivative C43 | Axon 2512
CAS [1262888-28-7]
MF C15H11F2N3MW 271.26
Purity:
99%
Soluble in DMSO
Description
Inhibitor of USP10 and USP13, that target the Beclin1 subunit of Vps34 complexes, thereby promoting the degradation of Vps34 PI3 kinase complexes. Beclin1 is a tumor suppressor and regulating deubiquitination activity of USP10 and USP13 by Beclin1 provides a mechanism for Beclin1 to control the levels of p53. Moreover, Spautin 1 inhibits autophagy which enhances imatinib-induced apoptosis in chronic myeloid leukemia. The pro-apoptotic activity of Spautin-1 was also associated with activation of GSK-3β, an important downstream effector of PI3K/AKT.
KEYWORDS: Spautin 1 | supplier | USP10-USP13 inhibitor | MBCQ derivative C43 | Spautin1 | CAS [1262888-28-7] | Ubiquitin | Deubiquitinase | Beclin 1 | Vps34 | PI3K | Akt | p53 | apoptosis | autophagy | GSK-3β | | axonmedchem |
| DU125530 | Axon 2750
CAS [161611-99-0]
MF C23H26ClN3O5SMW 491.99
Purity:
99%
Soluble in DMSO
Description
DU125530 is a selective 5-HT1A receptor antagonist (Ki value of 0.7 nM). DU-125530 showed equal (low nM) potency to displace agonist and antagonist binding to pre- and post-synaptic 5-HT1A receptors in rat and human brain.
KEYWORDS: DU125530 | supplier | 5-HT1A antagonist | DU 125530 | DU-125530 | CAS [161611-99-0] | Serotonin | 5-HT1A | Antagonist | Receptors | | axonmedchem |
| WAY 100135 dihydrochloride | Axon 1360
CAS [149055-79-8]
MF C24H33N3O2.2HClMW 468.46
Purity:
99%
Soluble in water
Description
Selective 5-HT1A antagonist
References
Certificates
Categories
Extra info
K Wedzony et al. WAY 100135, an Antagonist of 5-HT1A Serotonin Receptors, Attenuates Psychotomimetic Effects of MK-801. Neuropsychopharmacology 2000, 23, 547-559.
KF Rhodes et al. The antagonist actions of WAY 100135 and its enantiomers on 5-HT1A receptor-mediated hyperpolarization of the rat isolated superior cervical ganglion. Naunyn-Schmiedeberg's Arch. Pharmacol. 1993, 348(3), 225-227.
NA Escandon et al. Characterization of the serotonin1A receptor antagonist activity of WAY-100135 and spiperone. J. Pharmacol. Exp. Ther. 1994, 268, 441-447.
Certificate of Analysis
Material Safety Data Sheet
CNS
5-HT1A
A19
5-HT1A antagonist
Chemical name
N-tert-Butyl-3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-2-phenyl-propionamide dihydrochloride
Parent CAS No.
[133025-23-7]
Order
Size
Unit Price
Stock
10 mg
€75.00
In Stock | | axonmedchem |
| U 92016A | Axon 1285
CAS [149654-41-1]
MF C19H25N3.HClMW 331.88
Purity:
99%
Optical purity:
99% ee
Soluble in DMSO
Description
Selective orally active 5-HT1A full agonist with high intrinsic activity
References
Certificates
Categories
Extra info
RB McCall et al. Characterization of U-92016A as a selective, orally active, high intrinsic activity 5-hydroxytryptamine1A agonist. J. Pharmacol. Exp. Ther. 1994, 271(2), 875-883.
AG Romero et al. Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants. J. Med. Chem. 1993, 36(15), 2066–2074.
Certificate of Analysis
Material Safety Data Sheet
CNS
5-HT1A
A19
5-HT1A agonist
Chemical name
(R)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-2-carbonitrile hydrochloride
Parent CAS No.
[136924-88-4]
Order
Size
Unit Price
Stock
5 mg
€95.00
In Stock | | axonmedchem |
| WAY 100135 dihydrochloride, (-)- - WAY 100135 dihydrochloride, (R)- | Axon 1359
CAS [149007-53-4]
MF C24H33N3O2.2HClMW 468.46
Purity:
99%
Optical purity:
99% ee
Soluble in water
Description
R-enantiomer of WAY-100135 (Axon 1360), a highly selective serotonin 5-HT1A antagonist. Its opposite enantiomer, (S)-WAY100135 (Axon 1341) is also available
References
Certificates
Categories
Extra info
K Wedzony et al. WAY 100135, an Antagonist of 5-HT1A Serotonin Receptors, Attenuates Psychotomimetic Effects of MK-801. Neuropsychopharmacology 2000, 23, 547-559.
KF Rhodes et al. The antagonist actions of WAY 100135 and its enantiomers on 5-HT1A receptor-mediated hyperpolarization of the rat isolated superior cervical ganglion. Naunyn-Schmiedeberg's Arch. Pharmacol. 1993, 348(3), 225-227.
NA Escandon et al. Characterization of the serotonin1A receptor antagonist activity of WAY-100135 and spiperone. J. Pharmacol. Exp. Ther. 1994, 268, 441-447.
Certificate of Analysis
Material Safety Data Sheet
CNS
5-HT1A
A19
5-HT1A antagonist
Chemical name
(R)-N-tert-Butyl-3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-2-phenyl-propionamide dihydrochloride
Parent CAS No.
[133025-52-2]
Order
Size
Unit Price
Stock
5 mg
€95.00
In Stock | | axonmedchem |
| WAY 100135 dihydrochloride, (S)- - WAY 100135 dihydrochloride, (+)- | Axon 1341
CAS [149007-54-5]
MF C24H33N3O2.2HClMW 468.46
Purity:
99%
Optical purity:
99% ee
Soluble in water
Description
Highly selective serotonin 5-HT1A antagonist; S-enantiomer of WAY-100135 (Axon 1360). Its opposite enantiomer, (R)-WAY100135 (Axon 1359) is also available
References
Certificates
Categories
Extra info
K Wedzony et al. WAY 100135, an Antagonist of 5-HT1A Serotonin Receptors, Attenuates Psychotomimetic Effects of MK-801. Neuropsychopharmacology 2000, 23, 547-559.
KF Rhodes et al. The antagonist actions of WAY 100135 and its enantiomers on 5-HT1A receptor-mediated hyperpolarization of the rat isolated superior cervical ganglion. Naunyn-Schmiedeberg's Arch. Pharmacol. 1993, 348(3), 225-227.
NA Escandon et al. Characterization of the serotonin1A receptor antagonist activity of WAY-100135 and spiperone. J. Pharmacol. Exp. Ther. 1994, 268, 441-447.
Certificate of Analysis
Material Safety Data Sheet
CNS
5-HT1A
A19
5-HT1A antagonist
Chemical name
(S)-N-tert-Butyl-3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-2-phenyl-propionamide dihydrochloride
Parent CAS No.
[133025-53-3]
Order
Size
Unit Price
Stock
5 mg
€95.00
In Stock | | axonmedchem |
| LY 426965 dihydrochloride, (R)-(-)- | Axon 1095
CAS [228418-85-7]
MF C28H38N2O2.2HClMW 507.54
Purity:
99%
Optical purity:
99.0% ee
Soluble in DMSO
Description
Selective 5-HT1A antagonist; less active R-(-)-enantiomer of (±)-LY426965 (Axon 1093), in comparison with its opposite (S)-(+)-enantiomer, LY 426965 (Axon 1094)
References
Certificates
Categories
Extra info
K Rasmussen et al. The Novel 5-Hydroxytryptamine1A Antagonist LY426965: Effects on Nicotine Withdrawal and Interactions with Fluoxetine. J. Pharmcol. Exp. Ther. 2000, 294(2), 688-700.
R. Tordera et al. Effect of different 5-HT1A receptor antagonists in combination with paroxetine on expression of the immediate–early gene Arc in rat brain. Neuropharmacol. 2003, 44, 893-902.
Certificate of Analysis
Material Safety Data Sheet
CNS
5-HT1A
A19
5-HT1A antagonist
Chemical name
(R)-1-cyclohexyl-4-(4-(2-methoxyphenyl)piperazin-1-yl)-2-methyl-2-phenylbutan-1-one dihydrochloride
Parent CAS No.
[228418-83-5]
Order
Size
Unit Price
Stock
5 mg
€115.00
In Stock | | axonmedchem |
| LY 426965 dihydrochloride, (±)- - LY 426965 dihydrochloride, rac- | Axon 1093
CAS [228418-81-3]
MF C28H38N2O2.2HClMW 507.54
Purity:
99%
Soluble in DMSO
Description
Selective 5-HT1A antagonist; its (S)-(+)-enantiomer, LY 426965 (Axon 1094), is more active in comparison with (R)-(-)-LY 426965 (Axon 1095)
References
Certificates
Categories
Extra info
K Rasmussen et al. The Novel 5-Hydroxytryptamine1A Antagonist LY426965: Effects on Nicotine Withdrawal and Interactions with Fluoxetine. J. Pharmcol. Exp. Ther. 2000, 294(2), 688-700.
R. Tordera et al. Effect of different 5-HT1A receptor antagonists in combination with paroxetine on expression of the immediate–early gene Arc in rat brain. Neuropharmacol. 2003, 44, 893-902.
Certificate of Analysis
Material Safety Data Sheet
CNS
5-HT1A
A19
5-HT1A antagonist
Chemical name
1-Cyclohexyl-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-2-phenyl-butan-1-one dihydrochloride
Parent CAS No.
[228418-79-9]
Order
Size
Unit Price
Stock
10 mg
€115.00
In Stock | | axonmedchem |
| NPPCC, (-)- | Axon 1092
CAS [265644-16-4]
MF C20H30N2OMW 314.47
Purity:
98%
Optical purity:
>98% ee
No solubility data
Description
Potent and selective 5-HT1A receptor agonist
References
Certificates
Categories
Extra info
CNS
5-HT1A
A19
5-HT1A agonist
Chemical name
Cyclohexanecarboxylic acid ((S)-1-phenethyl-pyrrolidin-2-ylmethyl)-amide
Parent CAS No.
[265644-16-4]
Inquire | | axonmedchem |
| LY 426965 dihydrochloride - LY 426965 dihydrochloride, (S)-(+)- | Axon 1094
CAS [N.A]
MF C28H38N2O2.2HClMW 507.54
Purity:
98%
Optical purity:
98.8% ee
Soluble in DMSO
Description
Selective, potent, orally bioavailable full 5-HT1A antagonist; more active S-(+)-enantiomer of (±)-LY426965 (Axon 1093), in comparison with its opposite enantiomer, (R)-(-)-LY 426965 (Axon 1095)
References
Certificates
Categories
Extra info
K Rasmussen et al. The Novel 5-Hydroxytryptamine1A Antagonist LY426965: Effects on Nicotine Withdrawal and Interactions with Fluoxetine. J. Pharmcol. Exp. Ther. 2000, 294(2), 688-700.
R. Tordera et al. Effect of different 5-HT1A receptor antagonists in combination with paroxetine on expression of the immediate–early gene Arc in rat brain. Neuropharmacol. 2003, 44, 893-902.
Certificate of Analysis
Material Safety Data Sheet
CNS
5-HT1A
A19
5-HT1A antagonist
Chemical name
(S)-1-cyclohexyl-4-(4-(2-methoxyphenyl)piperazin-1-yl)-2-methyl-2-phenylbutan-1-one dihydrochloride
Parent CAS No.
[228418-82-4]
Order
Size
Unit Price
Stock
5 mg
€125.00
In Stock | | axonmedchem |
| PD 128907 hydrochloride, (+)- | Axon 1073
CAS [300576-59-4]
MF C14H19NO3.HClMW 285.77
Purity:
99%
Optical purity:
99% ee
Moderately soluble in water
Description
Standard selective D3 dopamine receptor agonist, more active enantiomer of trans-(±)-PD 128907 (Axon 1072). The less active enantiomer is available as Axon 1074.
References
Certificates
Categories
Extra info
Pugsley et al. Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907. J. Pharmacol. Exp. Ther. 1995, 275 1355.
Witkin et al. Atypical antipsychotic-like effects of the dopamine D3 receptor agonist (+)-PD 128907. Eur. J. Pharmacol. 1998, 347, R1.
Certificate of Analysis
Material Safety Data Sheet
CNS
D3
A17
D3 agonist
Chemical name
(4aR,10aR)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4,9-dioxa-1-aza-phenanthren-6-ol hydrochloride
Parent CAS No.
[123671-92-1]
Order
Size
Unit Price
Stock
5 mg
€110.00
In Stock | | axonmedchem |
| MPPI, p- | Axon 1091
CAS [155204-23-2]
MF C25H27IN4O2MW 542.41
Purity:
98%
Soluble in water
Description
Selective 5-HT1A antagonist; unlabelled standard in radiochemistry
References
Certificates
Categories
Extra info
Thielen et al. 4-(2′-Methoxyphenyl)-1-[2′-[N-(2′′-pyridinyl)-p-iodo-benzamido]ethyl]piperazine and p-fluorobenzamido]ethyl]piperazine, two new antagonists at pre- and postsynaptic serotonin-1A receptors. J. Pharmacol. Exp. Ther. 1996, 277, 661.
Kung et al. 4-(Methoxyphenyl)-1-[2′-(n-2″-pyridinyl)-p-iodobenzamido]-ethyl-piperazine ([125I]p-MPPI) as a new selective radioligand of serotonin-1A sites in rat brain. J. Pharmacol. Exp. Ther. 1995, 272, 429-437.
Certificate of Analysis
Material Safety Data Sheet
CNS
5-HT1A
A19
5-HT1A antagonist
Chemical name
4-Iodo-N-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-N-pyridin-2-yl-benzamide
Parent CAS No.
[155204-23-2]
Order
Size
Unit Price
Stock
10 mg
€110.00
In Stock | | axonmedchem |
| MPPF dihydrochloride, p- | Axon 1090
CAS [155204-26-5]
MF C25H27FN4O2.2HClMW 525.66
Purity:
99%
Soluble in water and DMSO
Description
Selective 5-HT1A antagonist, more potent than p-MPPI (Axon 1091).
KEYWORDS: p-MPPF dihydrochloride | supplier | 5-HT1A antagonist | MPPF | CAS [155204-26-5] | Serotonin | 5-HT1A | Antagonist | Receptors | | axonmedchem |