产品标题 产品货号 产品规格 厂家
Myeloperoxidase, Human Neutrophil | Athens Research & Technology16-14-130000sizeAthens Research
Myeloperoxidase Enzyme Immunoassay Kit | Athens Research & TechnologyK060-H1sizeAthens Research
ML 130 | NOD1 inhibitor | Noditinib | ML130 | ML-130 | CAS [799264-47-4] | Axon 1888 | Axon Ligand™ with >99% purity available from stock from supplier Axon MedchemAxon 1888 CAS [799264-47-4] MF C14H13N3O2SMW 287.34 Purity: 99% Soluble in DMSO Description Potent and selective inhibitor of NOD1. KEYWORDS: ML 130 | supplier | NOD1 inhibitor | Noditinib | ML130 | ML-130 | CAS [799264-47-4] | NF-κB Pathway | NOD1 | NLR | NACHT | leucine rich repeat domain containing proteins | innate | immunity | inflammation | apoptosisaxonmedchem
AX-024 hydrochloride | T cell receptor inhibitor | AX024 hydrochloride | AX 024 hydrochloride | AX-024 | AX024 | AX 024 | CAS [1704801-24-0] - [1370544-73-2] | Axon 2692 | Axon Ligand™ with >99% purity available from stock from supplier Axon MedchemAxon 2692 CAS [1704801-24-0] MF C21H22FNO2.HClMW 375.86 Purity: 99% Soluble in water and DMSO Description First-in-class inhibitor of T cell receptor (TCR); AX-024 is an orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 value 1 nM). By modulating TCR signaling, the inhibitor prevented the development of psoriasis and asthma and, furthermore, exerted a long-lasting therapeutic effect in a model of autoimmune encephalomyelitis. KEYWORDS: AX-024 hydrochloride | supplier | T cell receptor inhibitor | AX024 hydrochloride | AX 024 hydrochloride | AX-024 | AX024 | AX 024 | Ax24 | CAS [1704801-24-0] | [1370544-73-2] | Antigen | T cell | Inhibitor | Receptors | TCR | Autoimmune | Nck | TCR-Nck | Psoriasis | Asthma | Encephalomyelitisaxonmedchem
Temozolomide | DNA methylating agent | TMZ | NSC 362856 | SCH 52365 | CCRG 81045 | 97716-75-1 | Temodal | NSC362856 | SCH52365 | CCRG81045 | CAS [85622-93-1] | Axon 2326 | Axon Ligand™ with >100% purity available from stock from supplier Axon MedchemAxon 2326 CAS [85622-93-1] MF C6H6N6O2MW 194.15 Purity: 100% Soluble in 0.1N HCl(aq) and DMSO Description Chemotherapeutic apoptosis inducer. An orally active alkylating agent prodrug, delivering a methyl group to purine bases of DNA (O6-guanine; N7-guanine and N3-adenine). Temozolomide has demonstrated efficacy in the treatment of a variety of solid tumors, primary malignant brain tumors and metastatic melanoma (IC50 value 5 μM for cytotoxicity against mouse TLX5 lymphoma cells).The primary cytotoxic lesion, O6-methylguanine (O6-MeG) can be removed by methylguanine methyltransferase (MGMT; direct repair) in tumours expressing this protein, or tolerated in mismatch repair-deficient (MMR-) tumours. References Certificates Categories Extra info J. Zhang et al. Temozolomide: mechanisms of action, repair and resistance. Curr. Mol. Pharmacol. 2012, 5, 102-114.   H.S. Friedman et al. Temozolomide and treatment of malignant glioma. Clin. Cancer Res. 2000, 6, 2585-2597. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology DNA-damage Response DNA DNA methylating agent; apoptosis inducer Chemical name 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide Parent CAS No. [85622-93-1] Order Size Unit Price Stock 10 mg €50.00 In Stockaxonmedchem
RTA 408 | NRF2 acitivator | Omaveloxolone | RTA408 | CAS [1474034-05-3] | Axon 2497 | Axon Ligand™ with >98% purity available from stock from supplier Axon MedchemAxon 2497 CAS [1474034-05-3] MF C33H44F2N2O3MW 554.71 Purity: 98% Optical purity: Optically pure Soluble in DMSO Description Synthetic triterpenoid that potently activates the antioxidative transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) and inhibits the proinflammatory transcription factor NF-κB at low concentrations. RTA 408 dose-dependently reduced NO concentrations (IC50 value 4.4 Nm). At higher concentrations, RTA 408 inhibited tumor cell growth (GI50 value 260 nM) and increased caspase activity in tumor cell lines and is a highly effective mitigator of steady state hematopoiesis. KEYWORDS: RTA 408 | NRF2 acitivator | Axon 2497 | Omaveloxolone | RTA408 | CAS [1474034-05-3] | DNA-RNA | NRF | Activator | Transcription Factor | NF-E2L2 | ROS | NO | nuclear factor erythroid 2-related factor 2 | JNK | NF-κB | inflammatory | radiation | mitigator | hematopoiesisaxonmedchem
NEO 212 | DNA alkylating agent | TMZ-POH | TMZPOH | CAS [1361198-79-9] | Axon 2327 | Axon Ligand™ with >99% purity available from stock from supplier Axon MedchemAxon 2327 CAS [1361198-79-9] MF C17H20N6O4MW 372.38 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Novel DNA alkylating agent exhibiting superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo (IC50 values 5-50 µM for cytotoxicity on glioma cell lines). NEO 212 causes DNA damage and cell death much more efficiently than TMZ, because linkage with POH increased its biological half-life and thus provided greater opportunity for placement of cytotoxic DNA lesions.NEO212 is a conjugate of temozolomide (TMZ, Axon 2326) with the natural product perillyl alcohol (POH) and circumvents TMZ-resistance in multiple cancer cell lines and gliomas. References Certificates Categories Extra info T.C. Chen et al. A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo. Mol. Cancer Ther. 2014, 13, 1181-1193.   H.Y. Cho et al. NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas. Mol. Cancer Ther. 2014, 13, 2004-2017. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology DNA-damage Response DNA DNA alkylating agent; chemotherapeutic Chemical name (S)-(4-(Prop-1-en-2-yl)cyclohex-1-enyl)methyl 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonylcarbamate Parent CAS No. [1361198-79-9] Order Size Unit Price Stock 5 mg €110.00 In Stockaxonmedchem
ML334 | NRF2 acitivator | LH601A | ML-334 | LH-601A | CAS [1432500-66-7] | Axon 2641 | Axon Ligand™ with >99% purity available from stock from supplier Axon MedchemAxon 2641 CAS [1432500-66-7] MF C26H26N2O5MW 446.50 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Activator of NRF2 signaling by inhibition of Keap1-NRF2 protein-protein interaction (PPI; IC50 value 1.6 - 2.3 µM in a fluorescence polarisation assay using Keap1 Kelch domain/NRF2-ETGE peptide; Kd value 1 μM to Keap1 Kelch domain). ML 334 stimulates NRF2 expression and nuclear translocation, and induces antioxidant response elements (ARE) and transcription of HO-1 and TRX1 proteins. KEYWORDS: ML 334 | supplier | NRF2 acitivator | LH 601A | ML334 | LH601A | ML-334 | LH-601A | CAS [1432500-66-7] | DNA-RNA | NRF | Keap | Transcription Factor | Keap1-NRF2 | protein-protein interaction | Neurodegenerative | PPI | Kelch domain | expression | translocation | antioxidant response elements | HO-1 | TRX1axonmedchem
ML385 | NRF2 inhibitor | ML-385 | ML 385 | CAS [846557-71-9] | Axon 2671 | Axon Ligand™ with >99% purity available from stock from supplier Axon MedchemAxon 2671 CAS [846557-71-9] MF C29H25N3O4SMW 511.59 Purity: 99% Soluble in DMSO Description ML385 is an inhibitor of nuclear factor erythroid 2-related factor 2 (NRF2) (IC50 value 1.9 μM), blocks NRF2 transcriptional activity, and enhances the efficacy of carboplatin and other chemotherapeutic drugs in lung cancer cells (NSCLC). Specifically, ML385 binds to Neh1, the Cap ‘N’ Collar Basic Leucine Zipper (CNC-bZIP) domain of NRF2, and interferes with the binding of the V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homologue G (MAFG)-NRF2 protein complex to regulatory DNA binding sequences. ML385 shows specificity and selectivity for NSCLC cells with KEAP1 mutation. KEYWORDS: ML385 | supplier | NRF2 inhibitor | ML-385 | ML 385 | CAS [846557-71-9] | DNA-RNA | NRF | Keap | Inhibitor | Transcription Factors | NSCLC | KEAP1 | NRF2 | CNC-bZIP | MAFG | non-small cell lung canceraxonmedchem
2,5-Dimethylcelecoxib | Apoptosis inducer | DMC | CAS [457639-26-8] | Axon 2496 | Axon Ligand™ with >100% purity available from stock from supplier Axon MedchemAxon 2496 CAS [457639-26-8] MF C18H16F3N3O2SMW 395.40 Purity: 100% Soluble in DMSO Description Celecoxib analog that lacks COX-2 inhibitory activity but exhibits anti-tumor properties; DMC reduced growth and initiated apoptotic cell death in several MM cell lines. Mechanistically, DMC down-regulates critical components of the cell-cycle machinery (cyclins A and B); blocks the activity of important mitogenic and survival pathways (MEK, NF-κB, STAT3, survivin); and leads to increased caspase activity. Moreover, DMC quite potently mimics the ability of celecoxib to stimulate the endoplasmic reticulum stress response (ESR) and subsequent cell death . References Certificates Categories Extra info A. Kardosh et al. Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib. Blood. 2005 Dec 15;106(13):4330-8.   A. Kardosh et al. Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt's lymphoma in vitro and in vivo. Cancer Biol Ther. 2005 May;4(5):571-82.   P. Pyrko et al. Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib. Mol Cancer Ther. 2007 Apr;6(4):1262-75. Certificate of Analysis Material Safety Data Sheet Angiogenesis Cardiovascular Cell Cycle Regulation Cell Signaling & Oncology NF-κB MAPK JAK-STAT Unclassified Celecoxib analog with anti-tumor properties, lacking COX-2 inhibitory activity Chemical name 4-(5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide Parent CAS No. [457639-26-8] Order Size Unit Price Stock 10 mg €75.00 In Stockaxonmedchem
JSH 23 | NF-κB inhibitor | JSH23 | CAS [749886-87-1] | Axon 2349 | Axon Ligand™ with >99% purity available from stock from supplier Axon MedchemAxon 2349 CAS [749886-87-1] MF C16H20N2MW 240.34 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Inhibitor of NF-κB transcription and nuclear translocation of p65 (IC50 value 7.1 µM for inhibition of LPS-induced NF-κB transcriptional activity) without affecting IκBα degradation, which is a very rare mode of action. JSH 23 inhibited not only LPS-induced expressions of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and inducible nitric oxide synthase and cyclooxygenase-2 but also LPS-induced apoptosis of the RAW 264.7 cells. JSF 23 also inhibits NO production in LPS-stimulated macrophages RAW 264.7 (IC50 value 14.4 µM). KEYWORDS: JSH 23 | supplier | NF-κB inhibitor | JSH23 | CAS [749886-87-1] | NF-κB | Inhibitor | p65 | IκB | inflammation | transcription factor | Pro-inflammatory | cytokine | LPS | IKK | RAW 264.7 | COX-2axonmedchem
titleproductcodesizebrand
Myeloperoxidase, Human Neutrophil | Athens Research & Technology16-14-130000sizeAthens Research
Myeloperoxidase Enzyme Immunoassay Kit | Athens Research & TechnologyK060-H1sizeAthens Research
Haptoglobin, Human Plasma, Mixed Type | Athens Research & Technology16-16-080116sizeAthens Research
Apolipoprotein AI, Human Plasma | Athens Research & Technology16-16-120101sizeAthens Research
Vitronectin, Human Plasma | Athens Research & Technology16-16-220920sizeAthens Research
Laccase (LAC), Recombinant Microbial (Swissaustral USA) | Athens Research & Technology16-13-120100sizeAthens Research
Myeloperoxidase Enzyme Immunoassay Kit | Athens Research & TechnologyK060-H1sizeAthens Research
Anti-Thrombospondin Polyclonal Ab produced in rabbit | Athens Research & Technology01-20-201319sizeAthens Research
Anti-Trypsin Polyclonal Ab produced in rabbit | Athens Research & Technology01-19-032000sizeAthens Research
Anti-Myeloperoxidase Polyclonal Ab produced in rabbit | Athens Research & Technology01-14-130000sizeAthens Research
Anti-Haptoglobin Polyclonal Ab produced in rabbit | Athens Research & Technology01-16-080116sizeAthens Research
Anti-Fibrinogen Polyclonal Ab produced in rabbit | Athens Research & Technology01-16-060902sizeAthens Research
Anti-Elastase Polyclonal Ab produced in rabbit | Athens Research & Technology01-14-051200sizeAthens Research
Anti-Cathepsin L Polyclonal Ab produced in rabbit | Athens Research & Technology01-12-030112sizeAthens Research
Anti-Cathepsin D Polyclonal Ab produced in rabbit | Athens Research & Technology01-12-030104sizeAthens Research
Anti-Cathepsin H Polyclonal Ab produced in rabbit | Athens Research & Technology01-12-030108sizeAthens Research
Anti-Cathepsin B Polyclonal Ab produced in rabbit | Athens Research & Technology01-12-030102sizeAthens Research
Anti-Catalase Polyclonal Ab produced in rabbit | Athens Research & Technology01-05-030000sizeAthens Research
Anti-Azurocidin Polyclonal Ab produced in rabbit | Athens Research & Technology01-14-012621sizeAthens Research
Anti-Apolipoprotein CII Polyclonal Ab produced in rabbit | Athens Research & Technology01-16-120302sizeAthens Research
Anti-Apolipoprotein AI Polyclonal Ab produced in rabbit | Athens Research & Technology01-16-120101sizeAthens Research
Anti-Amylase Polyclonal Ab produced in rabbit | Athens Research & Technology01-19-010000sizeAthens Research
Glutamate Dehydrogenase, Recombinant Microbial (Swissaustral USA) | Athens Research & Technology16-13-070408sizeAthens Research
Catalase, Recombinant Microbial (Swissaustral USA) | Athens Research & Technology16-13-030000sizeAthens Research
Trypsin, Human Pancreas | Athens Research & Technology16-19-032000sizeAthens Research
Transferrin, Human Plasma, Bio Processing Grade | Athens Research & Technology16-16-032001-BPGsizeAthens Research
Transferrin, Rat Plasma | Athens Research & Technology16-16-032001-ratsizeAthens Research
Transferrin, Human Plasma (SIDERO), Partially Iron Saturated, Tissue Culture Grade | Athens Research & Technology16-16-S32001-LELsizeAthens Research
Transferrin (HOLO), Human Plasma, Tissue Culture Grade | Athens Research & Technology16-16-032001-LELsizeAthens Research
Transferrin (HOLO), Human Plasma | Athens Research & Technology16-16-032001sizeAthens Research
Transferrin, Cynomolgus Monkey Plasma | Athens Research & Technology16-16-032001-CMsizeAthens Research
Thrombospondin, Human Platelet | Athens Research & Technology16-20-201319sizeAthens Research
Superoxide Dismutase, Human Erythrocyte | Athens Research & Technology16-05-191504sizeAthens Research
S-100αα Protein, Bovine Brain | Athens Research & Technology16-BR-190801-bovinesizeAthens Research
S-100b Protein, Bovine Brain | Athens Research & Technology16-BR-190802-bovinesizeAthens Research
Secretory Immunoglobulin A, Human Colostrum (SigA) | Athens Research & Technology16-13-090701sizeAthens Research
S-100 Protein, Bovine Brain | Athens Research & Technology16-BR-190816-bovineAthens Research
Rheumatoid Factor IgM, Human Plasma | Athens Research & Technology16-16-180603sizeAthens Research
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